Cellular immune response to infection by different genotypes of hepatitis C virus

Ebeid, Mohamed E.; El-Bakry, Kadry A.

doi:10.1007/s12291-009-0044-8

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…In our study 9 patients (8.2%) had mixed infection with both genotypes 3 and 4, which was lower than that reported by a study in Egypt in 2009 where 34.28% patients were infected with genotypes 3and4. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Diversity of genotype and mode of spread of Hepatitis C virus in Northern India

Rehan

Manak

Yadav

et al. 2011

Saudi J Gastroenterol

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Background/Aim:Hepatitis C is caused by hepatitis C virus (HCV), which is classified into 6 genotypes. It leads to chronic hepatitis in 80% of the cases. Genotype of the virus helps in predicting response to antiviral therapy and also the duration of treatment. Therefore, it is important to know the prevalence of each genotype. Knowledge regarding the route of entry of HCV in the blood is also necessary to formulate a strategy to prevent its spread.Patients and Methods:One hundred and two newly diagnosed patients with chronic hepatitis C, having anti-HCV antibody-positive were included in the study. Their HCV RNA viral load and genotype were determined by Reverse Transcriptase PCR assay on Roche Cobas Ampliprep analyzer.Results:Genotype 3 was commonly detected in 58.8% patients followed by genotype 1 in 20.6%. Twelve patients had genotype 4 (11.8%) and 9 had mixed infection with genotypes 3 and 4. Among these patients, 43.1% of patients had a history of multiple injection exposure. Blood transfusion received by 6.9% and 2.9% had donated blood. Only 1 patient had a history of drug abuse.Conclusion:The distribution of genotypes varies in different regions and therefore its knowledge is important, as it determines the response of the patient to the treatment. The use of autodisabled syringes, their proper disposal, following biomedical waste management guidelines, and organizing continued medical education and workshops will help in preventing the spread of HCV infection.

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Section: Discussionmentioning

confidence: 99%

Diversity of genotype and mode of spread of Hepatitis C virus in Northern India

Rehan

Manak

Yadav

et al. 2011

Saudi J Gastroenterol

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“…Vitamin D also plays a role In treatment of HIV by regulating immune system [8]. The signs and symptoms are: Draining viably, Bruising easily, Fatigue, Poor yearning, Yellow discoloration of the skin and eyes (jaundice), Dark-tinted pee, Fluid accumulation in the liver (ascites) etc [9]. A couple of individuals clear HCV from their bodies after the exceptional stage, an outcome known as unconstrained viral elbowroom.…”

Section: Introductionmentioning

confidence: 99%

Occurence of Genotypes of Hepatitis C Virus in Hepatitis C Patients at Civil Hospital Khairpur, Sindh, Pakistan

Ali

Tunio²,

Farzana³

et al. 2021

JPRI

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Objective: To evaluate frequency of Hepatitis C virus Genotypes in Hepatitis C patients reported at Civil Hospital Khairpur, Sindh, Pakistan. Methodology: A descriptive cross sectional study was conducted on 223 hepatitis C patients who fulfilled the criteria at hepatitis OPD of Civil Hospital Khairpur, Sindh, Pakistan. After taken Patient consent, blood sample were collected for HCV genotyping, which were performed by a qualified pathologist. The collected data statistically analyzed by using SPSS version 22 software. Result: Out of 223 patients, male patients were 167 and females patients were 56, rural patients were 130 where as 93 patients were from urban area, 30 patients were of age from 20-25 years, 41 were of age from 26-30 years, 60 were of 31-35 years, 54 were of 36-40 years, 16 were of 41-45 years, 13 were of 46-50 years, 7 were of 51-55 years, 2 were of 56-60 years, out of total n=11 patients have genotype1, n=4 have genotype2, n=204 have genotype3, n=3 have genotype4, n=1 have genotype5, whereas no any patient have genotype 6. Conclusion: This study concluded that genotype 3 is most dominant among other genotypes in reported patients of hepatitis c virus infection at civil hospital Khairpur.

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“…The national prevalence rate of HCV antibody positivity has been estimated to be between 10-13% [2]. Hepatitis C affects nearly one in every 5 Egyptians which is highest prevalence all over the world .Most of Egyptian HCV patients are of gentype 4 where it represents 90% of all Egyptian HCV cases [3]. Genotype 4 is one of the neglected hepatitis C virus allover the world [4].…”

Section: Introductionmentioning

confidence: 99%