Cellular immunity in semistarved states in hospitalized adults

Bistrian, Bruce R.; Gl, Blackburn; Scrimshaw, Nevin S.; Jp, Flatt

doi:10.1093/ajcn/28.10.1148

Cited by 274 publications

(78 citation statements)

References 23 publications

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“…Most important, there was no correlation between serum transferrin and change in weight or serum albumin. This is distinctly different from the usual close correlation in serum transferrin and albumin in nondialysis populations [15]. Few of the serum transferrin levels were normal.…”

Section: Discussioncontrasting

confidence: 82%

Diagnosis of Protein Calorie Malnutrition in Diabetic Patients on Hemodialysis and Peritoneal Dialysis

Miller

Levine

Bistrian

et al. 1983

Nephron

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43 diabetic patients on hemodialysis (n = 26) and peritoneal dialysis (n = 17) underwent nutritional assessment by weight, midarm muscle circumference (MAMC), serum albumin, transferrin, prealbumin (PA) and retinol-binding protein (RBP). Serum ferritin was measured as an index of iron stores. The mean age was 48.5 years (range 26–76 years); mean length of diabetes was 22.8 years (range 9–50 years), and mean length of dialysis was 11.6 months (range 1–48 months). At the onset of dialysis 8 subjects (19%) were below 85% ideal weight and the mean serum albumin was 3.2 ± 0.4 g/dl. By the time of nutritional assessment 11 subjects (26%) were below 85% ideal weight, 19 subjects (44%) had a MAMC less than the 5th percentile, the mean serum albumin was 3.6 ± 0.5 g/dl, the mean serum transferrin was 124 ± 36 mg/dl, the mean PA was 330 ± 100 µg/ml and the mean RBP was 142 ± 25 µg/ml. There was a significant increase in serum albumin from 3.2 ± 0.4 to 3.6 ± 0.5 g/dl (p < 0.001) during the time of dialysis. Transferrin was low in 88% of the subjects and was negatively correlated with serum ferritin, but not with change in weight or serum albumin. RBP was elevated and PA was normal or elevated in all subjects regardless of nutritional status. By conventional nutritional assessment there is widespread malnutrition in diabetic patients on dialysis with 26% below 85% ideal weight, 41% with a serum albumin less than 3.5 g/dl and 42% with a MAMC less than the 5th percentile. The usual sensitive indicators of visceral protein status, serum transferrin, PA, and RBP, are not useful in dialyzed patients.

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Section: Discussioncontrasting

confidence: 82%

Diagnosis of Protein Calorie Malnutrition in Diabetic Patients on Hemodialysis and Peritoneal Dialysis

Miller

Levine

Bistrian

et al. 1983

Nephron

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“…*p < 0.05, **p < 0.01. Malnutrition causes reduced cellular immunity apart from aging (7,8). Tuberculin conversion by Bacille Celmette-Guerin vaccination is induced infrequently in malnourished people compared to well nourished (7,9).…”

Section: Resultsmentioning

confidence: 99%

“…Tuberculin conversion by Bacille Celmette-Guerin vaccination is induced infrequently in malnourished people compared to well nourished (7,9). Lymphopenia is often observed in the malnourished (8). Tuberculous patients frequently have emaciation, Fig.…”

Section: Resultsmentioning

confidence: 99%

Chest Roentgenogram Classification and Clinical Parameters in Patients with Active Pulmonary Tuberculosis.

et al. 1992

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“…Ancak, malnütrisyonu olan çocuklarda cerrahiye bağlı morbidite ve mortalitenin arttığı da unutulmamalıdır. Ayrıca ameliyat olsun veya olmasın herhangi bir sebepten ölen DKH'lı çocukların çoğunda malnütrisyon olduğu da bilinmektedir (18,19 Doğuştan kalp hastalığı olan hastalarda malnütrisyon ve büyüme geriliği birçok nedenle gelişebilmektedir, ancak en önemli etken yetersiz besin alımıdır (19,23,24). Malnütrisyona neden olan muhtemel mekanizmanın kalori ihtiyacının fazla olmasına rağmen, yetersiz kalori alımına, artmış metabolik hıza veya her ikisinin birlikteliğine bağlı olduğu düşünülmektedir (24).…”

Section: Discussionunclassified

The association between pulmonary arterial hypertension and malnutrition in children who had acyanotic congenital heart diseases with left to right shunt: an observational study

Altın¹,

Karataş²,

Şap³

et al. 2012

Anadolu Kardiyol Derg

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Sol-sağ şantlı doğuştan kalp hastalığı olan çocuklarda pulmoner arteriyel hipertansiyonla malnütrisyonun ilişkisi: Gözlemsel bir çalışmaThe association between pulmonary arterial hypertension and malnutrition in children with congenital heart diseases with left-to-right shunt: an observational study Özgün Araşt›rma Original Investigation ABSTRACTObjective: To evaluate the association between the degree of pulmonary arterial hypertension (PAH) and the level of malnutrition in children with acyanotic congenital heart diseases and left-to-right shunt, and especially to evaluate the development rates of malnutrition in patients with borderline PAH. Methods:The study was performed with data of 327 patients with acyanotic congenital heart diseases and left-to-right shunt and underwent cardiac catheterization between January 2001-February 2011. The design of the study was retrospective and observational. All patients were evaluated with anthropometric measurements, echocardiography and cardiac catheterization. They were classified according to the mean pulmonary artery pressure and level of malnutrition. Chi-square, ANOVA and Kruskal-Wallis tests were used for statistical analysis. Normally and abnormally distributed data were analyzed with Pearson and Spearman correlation tests respectively. Results: Malnutrition was detected in 94.8% of patients with PAH and 17.2% of no PAH patients according to Gomez classification (p<0.001). In addition, malnutrition was detected in 23.5% (16/68) of borderline PAH group. A negative association was detected between mean pulmonary arterial pressure and body weight for age (Gomez) and z scores of weight (p<0.001 for all). Z scores of weight and height were significantly decreased in patients with PAH in contrast to no PAH group (p<0.001, p<0.01 respectively). There was no statistical difference between no PAH and borderline PAH groups according to Gomez classification and relative body weight formula, however z scores of weight in borderline PAH group were decreased compared with no PAH group (p<0.001). . Sınırda PAH'ı olanların ise %23.5'inde (16/68) malnütrisyon tespit edildi. Ortalama pulmoner arter basıncı ile yaşa göre vücut ağırlığı (Gomez) ve kilo z skorları arasında negatif ilişki mevcuttu (her ikisi için p<0.001). Kilo ve boy z skorları da PAH olanlarda olmayanlara göre belirgin düşüktü (sırasıyla p<0.001, p<0.01). Gomez sınıflaması ve rölatif vücut ağırlığına göre PAH olmayan ve sınırda PAH olan gruplar arasında fark yoktu, ancak sınırda PAH grubunun kilo z skorları PAH olmayan gruba göre düşüktü (p<0.001). Sonuç: Asiyanotik sol-sağ şantlı DKH'lı çocuklarda PAB arttıkça, beraberinde malnütrisyon derecesinin de ağırlaştığı görüldü. Sınırda PAH'ı olan hastaların olmayanlara göre malnütrisyona daha fazla eğilimli olduğu izlendi, ancak bu konuda daha geniş kapsamlı araştırmaların yapılması gerektiği düşünüldü. (Anadolu Kardiyol Derg 2012; 12: 150-9) Anahtar kelimeler: Çocuk, malnütrisyon, doğuştan kalp hastalığı, pulmoner arteriyel hipertansiyon

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Cellular immunity in semistarved states in hospitalized adults

Cited by 274 publications

References 23 publications

Diagnosis of Protein Calorie Malnutrition in Diabetic Patients on Hemodialysis and Peritoneal Dialysis

Diagnosis of Protein Calorie Malnutrition in Diabetic Patients on Hemodialysis and Peritoneal Dialysis

Chest Roentgenogram Classification and Clinical Parameters in Patients with Active Pulmonary Tuberculosis.

The association between pulmonary arterial hypertension and malnutrition in children who had acyanotic congenital heart diseases with left to right shunt: an observational study

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