Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6

Strom, Alexander; Menart, Barbara; Simon, Marie‐Christine; Pham, Minh N.; Kolb, Hubert; Roden, Michael; Pozzilli, Paolo; Leslie, Richard; Schloot, Nanette C.

doi:10.1016/j.cyto.2012.01.002

Cited by 22 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main outcome of these recent studies is that systemic cytokines and chemokines do not differ comparing T1D and LADA. An increase of CCL3 has been seen for T1D/LADA compared to T2D; cytokines IL-1ra, IL-6 and TNF-a were lower in LADA/T1D compared to T2D; and in a Chinese study, IL-6 was higher in T2D compared to LADA and T1D [61][62][63][64]. Therefore, it is not unexpected that LADA does not differ from T1D, but we had expected that T2D might be different from LADA/ T1D because they have different metabolic conditions.…”

Section: Discussionmentioning

confidence: 94%

Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes

Simon

Bilan

Nowotny

et al. 2013

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryFatty acids, uric acid and glucose are thought to contribute to subclinical inflammation associated with diabetes mellitus. We tested whether co-incubation of free fatty acids and uric acid or glucose influences the secretion of immune mediators from stimulated human whole blood in vitro. -1), while IL-8 was up-regulated (P < 0·001). Samples from healthy and diabetic subjects did not differ after adjustment for age, sex, body mass index and diabetes type. All three fatty acids similarly influenced whole blood cytokine release in vitro and modulated uric acid or glucosestimulated cytokine secretion. Although the w-3-fatty acid EPA showed slightly stronger effects, further studies are required to elaborate the differential effects of PAL, LIN and EPA on disease risk observed previously in epidemiological studies.

show abstract

Section: Discussionmentioning

confidence: 94%

Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes

Simon

Bilan

Nowotny

et al. 2013

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…Similarly, the increase in IFN-g mRNA detected in whole blood from newly diabetic individuals compared with at-risk individuals was mimicked by a similar increase in IL-4 and IL-10 [22]. A separate analysis concluded that T cells from people with T1D produced equivalent amounts of IFN-g and IL-13 in response to autoantigens as T cells from control subjects [42]. Regarding the prediabetic period, the Th1 response to autoantigen has been reported to be increased in one study [43] and decreased in another [44] in at-risk individuals.…”

Section: Evidence Against the Th1 Paradigmmentioning

confidence: 97%

CD4 T cell differentiation in type 1 diabetes

Walker

Herrath

2015

Clinical and Experimental Immunology

155

113

View full text Add to dashboard Cite

SummarySusceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA) genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly infiltrate the islets, yet their activation and propagation probably requires CD4 T cell help. CD4 T cells can select from several differentiation fates following activation, and this choice has profound consequences for their subsequent cytokine production and migratory potential. In turn, these features dictate which other immune cell types T cells interact with and influence, thereby determining downstream effector functions. Obtaining an accurate picture of the type of CD4 T cell differentiation associated with a particular immune-mediated disease therefore constitutes an important clue when planning intervention strategies. Early models of T cell differentiation focused on the dichotomy between T helper type 1 (Th1) and Th2 responses, with type 1 diabetes (T1D) being viewed mainly as a Th1-mediated pathology. However, several additional fate choices have emerged in recent years, including Th17 cells and follicular helper T cells. Here we revisit the issue of T cell differentiation in autoimmune diabetes, highlighting new evidence from both mouse models and patient samples. We assess the strengths and the weaknesses of the Th1 paradigm, review the data on interleukin (IL)-17 production in type 1 diabetes and discuss emerging evidence for the roles of IL-21 and follicular helper T cells in this disease setting. A better understanding of the phenotype of CD4 T cells in T1D will undoubtedly inform biomarker development, improve patient stratification and potentially reveal new targets for therapeutic intervention.

show abstract

“…They have common predisposition haplotypes—together with T1D—HLA, INS VNTR, PTPN22, and T2D—TCF7L2 [10]. Immunopathogenesis includes common autoantibodies for T1D and LADA, and studies concerning changes in the level of inflammatory cytokines in LADA also demonstrate similarity to those in T1D rather than T2D [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population

Zaharieva

Velikova

Tsakova

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

Background The study aimed to estimate the prevalence of unrecognized cases with positive autoantibodies among type 2 diabetes (T2D) in a sample of the Bulgarian population and to compare some metabolic and inflammatory markers to those of patients having negative autoantibodies and subjects with latent autoimmune diabetes (LADA). Methods Patients with T2D, patients with LADA, and control participants were enrolled. Antiglutamic acid decarboxylase, anti-insulinoma-associated 2, and antizinc transporter 8 autoantibodies were assayed through ELISA. C-reactive protein and interleukin 6 (IL-6) and tumor necrosis factor alpha were assessed. Results Ten percent of patients with T2D had positive autoantibodies. They had lower body mass index (p = 0.014), worse glycemic control (HbA1c, p = 0.033), and better HDL cholesterol (p = 0.026) than those in negative autoantibodies cases. Compared to LADA, glycemia and anthropometric data did not differ significantly but metabolic syndrome was more prevalent among newly found cases with positive autoantibodies (p = 0.046). Their level of inflammatory markers was similar to that of patients having negative autoantibodies (p > 0.05), but IL-6 was higher when compared to LADA (p = 0.002). Conclusion Prevalence of patients having positive autoantibodies within T2D in the analyzed sample of the Bulgarian population was 10%. They shared common metabolic features with subjects with LADA, but inflammatory phenotype was closer to that of T2D.

show abstract

Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6

Cited by 22 publications

References 24 publications

Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes

Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes

CD4 T cell differentiation in type 1 diabetes

Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population

Contact Info

Product

Resources

About