Cellular internalization pathways of glucose-functionalized gold nanoparticles

Tzror-Azankot, Chen; Dreifuss, Tamar; Ben-Gal, Tal-Shachar; Jacob, Avi; Sadan, Tamar; Motiei, Menachem; Popovtzer, Rachela

doi:10.1117/12.2509605

Cited by 3 publications

(3 citation statements)

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“…187 AuNPs attached to the second carbon of glucose propound special features like targeting, the ability to differentiate between cancer and inammatory cells, enabling contrast ability and triggering clathrinmediated cellular uptake of NPs inside cancer cells depending on GLUT-1 expression. 188 Fabrication of different carbohydrate polymers into nanosystems can be achieved via the in situ copolymerization technique, solvent casting method or by the electrospinning technique. 189 Glyco-AuNPs can be synthesized through a one, two or three step reaction (Fig.…”

Section: Engineering Aunps With Saccharidesmentioning

confidence: 99%

“… 187 AuNPs attached to the second carbon of glucose propound special features like targeting, the ability to differentiate between cancer and inflammatory cells, enabling contrast ability and triggering clathrin-mediated cellular uptake of NPs inside cancer cells depending on GLUT-1 expression. 188 …”

Section: Engineering Aunps With Diverse Moieties For Bc Managementmentioning

confidence: 99%

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Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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Section: Engineering Aunps With Saccharidesmentioning

confidence: 99%

Section: Engineering Aunps With Diverse Moieties For Bc Managementmentioning

confidence: 99%

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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“…GNPs are small particles, made of gold, with one of their dimensions in the range of 1 to 100 nm. Their mode of synthesis, − size, − shape, − and coating − have a great impact on their toxicity, − ,, distribution, , internalization, − ,− ,− and their exocytosis . Our team developed a green, patented protocol to synthesize “green” GNPs (gGNPs). , Extracts from Hubertia ambavilla, an endemic plant from Reunion Island with bioreducing properties, were used to reduce gold salts and to stabilize GNPs.…”

Section: Introductionmentioning

confidence: 99%

Impact of Green Gold Nanoparticle Coating on Internalization, Trafficking, and Efficiency for Photothermal Therapy of Skin Cancer

Bonamy

Pesnel²,

Haddada³

et al. 2023

ACS Omega

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Skin cancer is a global health issue and mainly composed of melanoma and nonmelanoma cancers. For the first clinical proof of concept on humans, we decided to study good prognosis skin cancers, i.e., carcinoma basal cell. In UE, the first-line treatment remains surgical resection, healing most of the tumors, but presents aesthetic disadvantages with a high reoccurrence rate on exposed areas. Moreover, the therapeutic indications could extend to melanoma and metastasis, which is a different medical strategy that could combine this treatment. Indeed, patients with late-stage melanoma are in a therapeutic impasse, despite recent targeted and immunological therapies. Photothermal therapy using gold nanoparticles is the subject of many investigations due to their strong potential to treat cancers by physical, thermal destruction. We developed gold nanoparticles synthesized by green chemistry (gGNPs), using endemic plant extract from Reunion Island, which have previously showed their efficiency at a preclinical stage. Here, we demonstrate that these gGNPs are less cytotoxic than gold nanoparticles synthesized by Turkevich’s method. Furthermore, our work describes the optimization of gGNP coating and stabilization, also taking into consideration the gGNP path in cells (endocytosis, intracellular trafficking, and exocytosis), their specificity toward cancerous cells, their cytotoxicity, and their in vivo efficiency. Finally, based on the metabolic switch of cancerous cells overexpressing Glut transporters in skin cancers, we demonstrated that glucose-stabilized gGNP (gGNP@G) enables a quick internalization, fourfold higher in cancerous cells in contrast to healthy cells with no side cytotoxicity, which is particularly relevant to target and treat cancer.

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