Cellular Localization of the Group II Pepsinogens in Human Stomach and Duodenum by Immunofluorescence

Samloff, I. Michael; Liebman, William M.

doi:10.1016/s0016-5085(19)33138-5

Cited by 220 publications

(82 citation statements)

References 14 publications

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“…This correlation has not been indicated previously, but it is reasonable, because PG II is derived not only from the pyloric gland but also from the fundic gland. 2 Some previous studies 3, 8 have indicated that, besides PG I, the PG I/II ratio also reflects gastric acid secretion. The present study revealed that although this was true for the H. pylori-positive subject group, it could not be applied for the H. pylori-negative subjects.…”

Section: Discussionmentioning

confidence: 96%

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Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects

et al. 2005

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The correlations between serum pepsinogens and gastric acid secretion differ, depending on the presence or absence of H. pylori infection. With the use of serum pepsinogens as a simple measure of gastric acid secretion, therefore, consideration of H. pylori infection status is needed. Because the determination of the acid secretory level has some clinical implications in both H. pylori-positive and -negative subjects, its estimation by serum pepsinogen concentrations can be of practical use.

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Section: Discussionmentioning

confidence: 96%

“…2 Serum PG concentrations have been shown to reflect the morphological 3,4 and functional [5][6][7][8] status of the gastric mucosa. Previous studies indicated that the serum PG I level, [5][6][7][8][9][10][11] as well as the PG I/II 3,8 ratio, were positively correlated with maximal gastric output.…”

Section: Introductionmentioning

confidence: 99%

Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects

et al. 2005

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“…The latter include the aspartic proteinases cathepsin E (15) and pepsino- gens I and II, which were detected with rabbit antisera specific for each antigen (39); M1, an antigen associated with the peptide core of gastric superficial-foveolar mucin cells, using a pool of four monoclonal antibodies (2) applied to sections pretreated for 15 min with 0.004% proteinase XXIV (Sigma, St. Louis, Mo. ); M3SI, a mucin antigen expressed in small intestinal goblet cells, which was detected with mAb 64 or 168 (26) and CAR5, a mucin like antigen expressed mainly in colorectal epithelium and reacting with mAb BD5 (34).…”

Section: Study Materialsmentioning

confidence: 99%

Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients

Sessa

Solcia

Capella

et al. 1994

Vichows Archiv A Pathol Anat

333

238

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Intraductal papillary growth of mucin producing hypersecreting, columnar cells characterizes a group of rare pancreatic exocrine neoplasms which we propose to call intraductal papillary-mucinous tumors (IPMT). We analysed the histopathology of 26 IPMT in relation to gastro-enteropancreatic marker expression, genetic changes and biology. Four IPMT showing only mild dysplasia were considered to be adenomas. Nine tumours displayed moderate dysplasia and were regarded as borderline. Severe dysplasia-carcinoma in situ changes were found in 13 IPMT which were therefore classified as intraductal carcinomas. Six of these carcinomas were frankly invasive and two of these had lymph node metastases. The invasive component resembled mucinous non-cystic carcinoma in all but one tumour which showed a ductal invasion pattern. Immunohistochemically, an intestinal marker type was found in most carcinomas, while gastric type differentiation prevailed among adenomas or borderline tumours. K-ras mutations (seven at codon 12 and one at codon 13) were found in 31% of IPMT (2 adenomas, 1 borderline, 5 carcinomas). Nuclear p53 overexpression was detected in 31% of IPMT (6 carcinomas and 2 borderline IPMT) and correlated with p53 mutations (one at exon 8 and the other at exon 5) in two carcinomas. p53 abnormalities were unrelated to K-ras mutation. c-erbB-2 overexpression was observed in 65% of IPMT, with various grades of dysplasia. Twenty-two of 24 patients are alive and well after a mean post-operative follow-up of 41 months. Only two patients, both with invasive cancer at the time of surgery, died of tumour disease. It is concluded that pancreatic IPMT encompass neoplasms which, in general, have a favorable prognosis, but are heterogeneous in regard to grade of dysplasia and marker expression. Adenoma, borderline tumour, intraductal carcinoma and invasive carcinoma can be differentiated. p53 changes but not K-ras mutation or c-erbB-2 overexpression are related to the grade of malignancy. Most IPMT differ in histological structure, marker expression and behaviour from ductal adenocarcinoma.

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“…Human pepsinogens I (PGI; coded by pepsinogen A, termed PGA) and II (PGII; coded by pepsinogen C, termed PGC) are proenzymes of pepsin (Foltmann 1981;Tang and Wong 1987;Kageyama 2002). PGI is mainly secreted from chief cells in the fundic mucosa (SamloV 1971), whereas PGII is secreted from the pyloric gland and proximal duodenal mucosa (SamloV and Liebman 1973). As for serum pepsinogen levels in gastric cancer patients, low levels of PGI and the resultant reduced PGI/PGII ratios were signiWcant compared with those in normal controls (Miki et al 1989;Ley et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression

Tani

Akiyama

Fukamachi

et al. 2006

J Cancer Res Clin Oncol

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Cellular Localization of the Group II Pepsinogens in Human Stomach and Duodenum by Immunofluorescence

Cited by 220 publications

References 14 publications

Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects

Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects

Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression

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