Cellular Membrane Enrichment of Self-Assembling <scp>d</scp>-Peptides for Cell Surface Engineering

Wang, Huaimin; Han, Aitian; Cai, Yanbin; Xiao, Nannan; Yang, Zhimou

doi:10.1021/am502250r

Cited by 24 publications

(22 citation statements)

References 57 publications

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“…Wang et al developed self-assembling peptides with L- and D-amino acids (NBD-DFDFDYGLKKTETQ) and studied their biological functions in cells. Interestingly, the result demonstrated that the utilization of D-amino acids in self-assembling peptides boosts their cellular membrane localization [87]. D-amino acids were specially enriched in cellular membranes at self-assembled stages.…”

Section: Biomedical Applications Of Self-assembling Peptide-based mentioning

confidence: 99%

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Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

et al. 2016

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Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures over other delivery platforms include their chemical diversity, biocompatibility, high loading capacity for both hydrophobic and hydrophilic drugs, and their ability to target molecular recognition sites. Furthermore, these self-assembled nanostructures could be designed with novel peptide motifs, making them stimuli-responsive and achieving triggered drug delivery at disease sites. The goal of this work is to present a comprehensive review of the most recent studies on self-assembled peptides with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers.

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Section: Biomedical Applications Of Self-assembling Peptide-based mentioning

confidence: 99%

“…However they were distributed uniformly in the cytoplasma of cells at unassembled stages. Wang et al [87] demonstrated the possibility of using such D-amino acid-based peptides to engineer cell surfaces.…”

Section: Biomedical Applications Of Self-assembling Peptide-based mentioning

confidence: 99%

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

et al. 2016

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“…This observation could in principle be exploited for the targeted delivery of a small molecule that has a specific site of action located at the cell membrane [50]. …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

Melchionna¹,

Styan²,

Marchesan

2016

CTMC

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Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems. D-amino acids are typically introduced to increase the peptide enzymatic stability. However, there are several reports of unexpected effects on peptide conformation, self-assembly behavior, cytotoxicity and even therapeutic activity. This mini-review discusses all the surprising twists of heterochiral self-assembled peptide hydrogels, and delineates emerging key findings to exploit all the benefits of D-amino acids in this novel medicinal area.

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“…Then, we discuss the less expected enzyme reactions of D-amino acid, especially highlighting the recent study of D-amino acids for enzyme-instructed self-assembly (EISA), which results in selectivity in potential anti-inflammatory or anticancer drug approaches. We hope that these discussions will help readers to appreciate the study of D-amino acids in achieving biostability(17, 18), investigating interactions between enzymes and D-peptides(19, 20), and improving bioactivities via the introduction of D-amino acids(21, 22). …”

Section: Introductionmentioning

confidence: 99%

Inspiration from the mirror: D-amino acid containing peptides in biomedical approaches

Feng

2016

Biomolecular Concepts

127

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D-amino acids, the enantiomers of naturally abundant L-amino acids, bears unique stereochemistry properties that lead to the resistance towards most of endogenous enzymes. Previous works have demonstrated the applications of D-amino acids in therapeutics development with the aid of mirror-image phage display and retro-inverso peptide synthesis. In this review, we highlight the recent progresses and challenges in the exploration of D-amino acids at the interface of chemistry and life science. First we will introduce some progresses of traditional application of D-amino acids to enhance biostability of peptide therapeutics. Then we discuss some works that explore the relatively underexplored interactions between enzyme and D-amino acids and enzymatic reactions of D-amino acids. To highlight the enzymatic reactions of D-amino acids, we will describe several emerging works on the enzyme-instructed self-assembly (EISA) and their potential application in selective anti-inflammatory or anticancer therapies. At the end, we briefly mention the challenges and possible future directions.

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Cellular Membrane Enrichment of Self-Assembling d-Peptides for Cell Surface Engineering

Cited by 24 publications

References 57 publications

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

Inspiration from the mirror: D-amino acid containing peptides in biomedical approaches

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