Cellular positioning and dendritic field size of cholinergic amacrine cells are impervious to early ablation of neighboring cells in the mouse retina

Farajian, Reza; Raven, Mary A.; Cusato, K.; Reese, Benjamin E.

doi:10.1017/s0952523804041021

Cited by 47 publications

(44 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other examples of this form of dendritic control have been suggested (Wässle et al, 1981;Perry and Linden, 1982;Amthor and Oyster, 1995;Grueber et al, 2003), but recent evidence now calls into question this mechanism, at least for two types of retinal ganglion cell (Lin et al, 2004) and for cholinergic amacrine cells (Farajian et al, 2004). How the horizontal cells, with a coverage factor of ϳ6 -7, coordinate their growth to achieve this dendritic coverage across a wide variation in density between different strains of mice is presently unclear.…”

Section: Dendritic Field Area Is Scaled To Densitymentioning

confidence: 99%

Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage

Reese¹,

Raven²,

Stagg³

2005

J. Neurosci.

101

View full text Add to dashboard Cite

Horizontal cells are inhibitory interneurons with laterally oriented dendrites that overlap one another, contacting the pedicles of cone photoreceptors. Because of their regular spacing, the network of horizontal cells provides a uniform coverage of the retinal surface. The developmental processes establishing these network properties are undefined, but cell-intrinsic instructions and interactions with other cells have each been suggested to play a role. Here, we show that the intercellular spacing of horizontal cells is essentially independent of genetic background and is predicted by local density, suggesting that horizontal cell positioning is modulated by proximity to other horizontal cells. Dendritic field area compensates for this variation in intercellular spacing, maintaining constant dendritic coverage between strains. Functional dendritic overlap is achieved anatomically at the level of the pedicles, where horizontal cells interact with one another to establish their connectivity: the number of dendritic terminals contacting a pedicle changes, reciprocally, between neighboring horizontal cells during development based on their relative proximity to each pedicle. Cellular morphology is also shown to be regulated by the afferents themselves: afferent elimination before innervation does not alter dendritic field size nor stratification but compromises dendritic branching and prevents terminal formation. Afferent and homotypic interactions therefore generate the morphology, spacing, and connectivity of horizontal cells underlying their functional coverage of the retina.

show abstract

Section: Dendritic Field Area Is Scaled To Densitymentioning

confidence: 99%

Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage

Reese¹,

Raven²,

Stagg³

2005

J. Neurosci.

101

View full text Add to dashboard Cite

show abstract

“…A drawing of a single starburst cell dendrite is provided (Fig. 8 A) as a reference to the different regions and to show that the distal dendritic segments of these cells are relatively thicker than proximal branches and thus have greater membrane surface area (Miller and Bloomfield, 1983;Poznanski, 1992;Farajian et al, 2004).…”

Section: Cellular and Subcellular Localization Of Kv31 And Kv32 Promentioning

confidence: 99%

A Unique Role for Kv3 Voltage-Gated Potassium Channels in Starburst Amacrine Cell Signaling in Mouse Retina

Ozaita¹,

Petit-Jacques²,

Völgyi³

et al. 2004

J. Neurosci.

View full text Add to dashboard Cite

Direction-selective retinal ganglion cells show an increased activity evoked by light stimuli moving in the preferred direction. This selectivity is governed by direction-selective inhibition from starburst amacrine cells occurring during stimulus movement in the opposite or null direction. To understand the intrinsic membrane properties of starburst cells responsible for direction-selective GABA release, we performed whole-cell recordings from starburst cells in mouse retina. Voltage-clamp recordings revealed prominent voltagedependent K ϩ currents. The currents were mostly blocked by 1 mM TEA, activated rapidly at voltages more positive than Ϫ20 mV, and deactivated quickly, properties reminiscent of the currents carried by the Kv3 subfamily of K ϩ channels. Immunoblots confirmed the presence of Kv3.1 and Kv3.2 proteins in retina and immunohistochemistry revealed their expression in starburst cell somata and dendrites. The Kv3-like current in starburst cells was absent in Kv3.1-Kv3.2 knock-out mice. Current-clamp recordings showed that the fast activation of the Kv3 channels provides a voltage-dependent shunt that limits depolarization of the soma to potentials more positive than Ϫ20 mV. This provides a mechanism likely to contribute to the electrical isolation of individual starburst cell dendrites, a property thought essential for direction selectivity. This function of Kv3 channels differs from that in other neurons where they facilitate highfrequency repetitive firing. Moreover, we found a gradient in the intensity of Kv3.1b immunolabeling favoring proximal regions of starburst cells. We hypothesize that this Kv3 channel gradient contributes to the preference for centrifugal signal flow in dendrites underlying direction-selective GABA release from starburst amacrine cells

show abstract

“…Following ablation of RGCs or starburst amacrine cells, the surviving cells developed regularly spaced dendrite arbors that exhibited a limited ability to expand into unoccupied territory (Farajian et al, 2004;Lin et al, 2004). Therefore, interactions between neighboring dendrites are largely dispensable for maintenance of coverage in these neurons and unknown constraints limit their growth potential.…”

Section: Introductionmentioning

confidence: 99%

The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth

et al. 2014

View full text Add to dashboard Cite

As animals grow, many early born structures grow by cell expansion rather than cell addition; thus growth of distinct structures must be coordinated to maintain proportionality. This phenomenon is particularly widespread in the nervous system, with dendrite arbors of many neurons expanding in concert with their substrate to sustain connectivity and maintain receptive field coverage as animals grow. After rapidly growing to establish body wall coverage, dendrites of Drosophila class IV dendrite arborization (C4da) neurons grow synchronously with their substrate, the body wall epithelium, providing a system to study how proportionality is maintained during animal growth. Here, we show that the microRNA bantam (ban) ensures coordinated growth of C4da dendrites and the epithelium through regulation of epithelial endoreplication, a modified cell cycle that entails genome amplification without cell division. In Drosophila larvae, epithelial endoreplication leads to progressive changes in dendrite-extracellular matrix (ECM) and dendrite-epithelium contacts, coupling dendrite/substrate expansion and restricting dendrite growth beyond established boundaries. Moreover, changes in epithelial expression of cell adhesion molecules, including the beta-integrin myospheroid (mys), accompany this developmental transition. Finally, endoreplication and the accompanying changes in epithelial mys expression are required to constrain late-stage dendrite growth and structural plasticity. Hence, modulating epithelium-ECM attachment probably influences substrate permissivity for dendrite growth and contributes to the dendrite-substrate coupling that ensures proportional expansion of the two cell types.

show abstract

Cellular positioning and dendritic field size of cholinergic amacrine cells are impervious to early ablation of neighboring cells in the mouse retina

Cited by 47 publications

References 62 publications

Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage

Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage

A Unique Role for Kv3 Voltage-Gated Potassium Channels in Starburst Amacrine Cell Signaling in Mouse Retina

The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth

Contact Info

Product

Resources

About