Cellular-resolution gene expression profiling in the neonatal marmoset brain reveals dynamic species- and region-specific differences

Kita, Yoshiaki; Nishibe, Hirozumi; Wang, Yan; Hashikawa, Tsutomu; Kikuchi, Shunsuke; Mami, U; Yoshida, Aya; Yoshida, Chihiro; Kawase, Takashi; Ishii, Shin; Skibbe, Henrik; Shimogori, Tomomi

doi:10.1073/pnas.2020125118

Cited by 31 publications

(32 citation statements)

References 59 publications

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“…Although the rodent prostriata has strong reciprocal connections with the PrS-PoS (Chen et al, 2020;2021), many major connectional differences exist between the two structures in addition to the molecular differences described in the present study. First, the PrS-PoS receives direct projections from hippocampal CA1 (Ding et al, 2020) while the prostriata does not (Chen et al, 2021;Hu et al, 2020).…”

Section: Comparison Of the Prostriata With Presubiculum Parasubiculum...mentioning

confidence: 60%

“…To explore if the prostriata has some conservative gene expression between mice and marmoset monkeys, we have carried out a survey on the Riken marmoset database (https://gene-atlas.brainminds.riken.jp), which mainly contains the ISH data from postnatal stages (mostly at P0; see Kita et al, 2021; Shimogori et al, 2018). As expected, some genes indeed show similar expression patterns between the two species.…”

Section: Resultsmentioning

confidence: 99%

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Chemo-architecture of area prostriata in adult and developing mice: comparison with presubiculum and parasubiculum

Chen

Xiang

et al. 2022

Preprint

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Retrosplenial area 29e, which was a cortical region described mostly in earlier rodent literature, is often included in the dorsal presubiculum (PrSd) or postsubiculum (PoS) in modern literature and commonly used brain atlases. Recent anatomical and molecular studies have revealed that retrosplenial area 29e belongs to the superficial layers of area prostriata, which in primates is found to be important in fast analysis of quickly moving objects in far peripheral visual field. As in primates, the prostriata in rodents adjoins area 29 (granular retrosplenial area), area 30 (agranular retrosplenial area), medial visual cortex, PrSd-PoS, parasubiculum (PaS) and postrhinal cortex (PoR). The present study aims to reveal the chemo-architecture of the prostriata versus PrSd-PoS or PaS by means of a systematic survey of gene expression patterns in adult and developing mouse brains. First, we find many genes that display differential expression across the prostriata, PrSd-PoS and PaS and that show obvious laminar expression patterns. Second, we reveal subsets of genes that selectively express in the dorsal or ventral parts of the prostriata, suggesting the existence of at least two subdivisions. Third, we detect some genes that shows differential expression in the prostriata of postnatal mouse brains from adjoining regions, thus enabling identification of the developing area prostriata. Fourth, gene expression difference of the prostriata from the medial visual cortex and PoR is also observed. Finally, molecular and connectional features of the prostriata in rodents and non-human primates are discussed and compared.

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Section: Comparison Of the Prostriata With Presubiculum Parasubiculum...mentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Chemo-architecture of area prostriata in adult and developing mice: comparison with presubiculum and parasubiculum

Chen

Xiang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…To explore if the prostriata has some conservative gene expression between mice and marmoset monkeys, we have carried out a survey on the Riken marmoset database (https://gene-atlas.brainminds.riken.jp), which mainly contains the ISH data from postnatal stages (mostly at P0; see Kita et al., 2021; Shimogori et al., 2018). As expected, some genes indeed show similar expression patterns between the two species.…”

Section: Resultsmentioning

confidence: 99%

Chemoarchitecture of area prostriata in adult and developing mice: Comparison with presubiculum and parasubiculum

Chen

Xiang

et al. 2022

J of Comparative Neurology

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Retrosplenial area 29e, which was a cortical region described mostly in earlier rodent literature, is often included in the dorsal presubiculum (PrSd) or postsubiculum (PoS) in modern literature and commonly used brain atlases. Recent anatomical and molecular studies have revealed that retrosplenial area 29e belongs to the superficial layers of area prostriata, which in primates is found to be important in fast analysis of quickly moving objects in far peripheral visual field. As in primates, the prostriata in rodents adjoins area 29 (granular retrosplenial area), area 30 (agranular retrosplenial area), medial visual cortex, PrSd/PoS, parasubiculum (PaS), and postrhinal cortex (PoR). The present study aims to reveal the chemoarchitecture of the prostriata versus PrSd/PoS or PaS by means of a systematic survey of gene expression patterns in adult and developing mouse brains. First, we find many genes that display differential expression across the prostriata, PrSd/PoS, and PaS and that show obvious laminar expression patterns. Second, we reveal subsets of genes that selectively express in the dorsal or ventral parts of the prostriata, suggesting the existence of at least two subdivisions. Third, we detect some genes that shows differential expression in the prostriata of postnatal mouse brains from adjoining regions, thus enabling identification of the developing area prostriata. Fourth, gene expression difference of the prostriata from the medial primary visual cortex and PoR is also observed. Finally, molecular and connectional features of the prostriata in rodents and nonhuman primates are discussed and compared.

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“…Alternatively, at least in this part of the striatum, the extent of CDt itself may spread out more dorsally than that of more caudal CDt which did not contain the poor zones. A recent online atlas on marmosets 2 (Shimogori et al, 2018;Kita et al, 2021) supported the uneven distribution of D1R/D2R expressing cells (Drd1, ID#369-1 and #N-2; Drd2, ID #AA-2). The cStr, including poor zones, is innervated by the sensory cortices, which implies a possible relationship between sensory inputs and the poor zone development.…”

Section: Dual Pathway Neurons In Dopamine Receptor D1-and Dopamine Re...mentioning

confidence: 94%

Conservation of the Direct and Indirect Pathway Dichotomy in Mouse Caudal Striatum With Uneven Distribution of Dopamine Receptor D1- and D2-Expressing Neurons

et al. 2022

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The striatum is one of the key nuclei for adequate control of voluntary behaviors and reinforcement learning. Two striatal projection neuron types, expressing either dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R) constitute two independent output routes: the direct or indirect pathways, respectively. These pathways co-work in balance to achieve coordinated behavior. Two projection neuron types are equivalently intermingled in most striatal space. However, recent studies revealed two atypical zones in the caudal striatum: the zone in which D1R-neurons are the minor population (D1R-poor zone) and that in which D2R-neurons are the minority (D2R-poor zone). It remains obscure as to whether these imbalanced zones have similar properties on axonal projections and electrophysiology compared to other striatal regions. Based on morphological experiments in mice using immunofluorescence, in situ hybridization, and neural tracing, here, we revealed that the poor zones densely projected to the globus pallidus and substantia nigra pars lateralis, with a few collaterals in substantia nigra pars reticulata and compacta. Similar to that in other striatal regions, D1R-neurons were the direct pathway neurons. We also showed that the membrane properties of projection neurons in the poor zones were largely similar to those in the conventional striatum using in vitro electrophysiological recording. In addition, the poor zones existed irrespective of the age or sex of mice. We also identified the poor zones in the common marmoset as well as other rodents. These results suggest that the poor zones in the caudal striatum follow the conventional projection patterns irrespective of the imbalanced distribution of projection neurons. The poor zones could be an innate structure and common in mammals. The unique striatal zones possessing highly restricted projections could relate to functions different from those of motor-related striatum.

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Cellular-resolution gene expression profiling in the neonatal marmoset brain reveals dynamic species- and region-specific differences

Cited by 31 publications

References 59 publications

Chemo-architecture of area prostriata in adult and developing mice: comparison with presubiculum and parasubiculum

Chemo-architecture of area prostriata in adult and developing mice: comparison with presubiculum and parasubiculum

Chemoarchitecture of area prostriata in adult and developing mice: Comparison with presubiculum and parasubiculum

Conservation of the Direct and Indirect Pathway Dichotomy in Mouse Caudal Striatum With Uneven Distribution of Dopamine Receptor D1- and D2-Expressing Neurons

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