Cellular response on Auger- and Beta-emitting nuclides: Human embryonic stem cells (hESC) vs. keratinocytes

Abstract

Human embryonic stem cells respond to ionizing radiation by (125)I-dU and (131)I in a different way compared to keratinocytes. Transcriptional response and gene expression appear to facilitate an escape from programmed cell death by striking a new path which probably leads to cell differentiation.

Synthesis and evaluation of radioiodinated estrogens for diagnosis and therapy of male urogenital tumours

“…5 Auger electrons are emitted from I-123 or I-125 at ultra-short ranges (within the dimensions of a cell nucleus) and offer the advantage of high specific cytotoxicity combined with relatively few side effects. 6,7 Iodine-131 is a beta emitter that has proven its worth in radiotherapy over decades. 8 For a selective coupling of iodine isotopes, radioiododestannylation is the standard method.…”