Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

Degradation of bioabsorbable Mg-based alloys: Assessment of the effects of insoluble corrosion products and joint effects of alloying components on mammalian cells

“…For these assays the corresponding salts (2.5 × 10 3 μM, 3.3 × 10 3 μM, 4.1 × 10 3 μM and 8.2 × 10 3 μM MgSO 4 ; 200 μM LaCl 3 •7H 2 0; and 50 and 100 μM ZnCl 2 , Sigma-Aldrich, St. Louis, MO, USA) dissolved in the CCM were employed. The selection of RE/Mg concentration relationships for these assays was based on the results of our previous report [61]. For the selection of Zn ion concentrations, a dose-response analysis considering the 50-250 μM dose range was performed.…”

“…Thus, it is interesting to investigate which of the components may be the most dangerous and the possibility of joint effects. Beneficial and detrimental cellular effects were informed for La, Mg and Zn [56,61,[65][66][67]. It has been reported that high levels of intracellular Zn induce apoptosis in different cell types and tissues.…”

Corrosion Behavior and Osteogenic Activity of a Biodegradable Orthopedic Implant Mg–Si Alloy with a Gradient Structure

“…The cell viability (Figure 6a) of MC3T3-E1 cells co-cultured in the negative control group, MS8, GMS8-1 and GMS8-2 extractions for 3 days shows that all the 10%, 30% and 50% extracts from GMS8-1 and GMS8-2 exhibit higher cell viability than the control group and the cytotoxicity is of grades 0-1 [38]. Cell viability is always connected to the ion concentrations in the co-culture medium [39,40]. The concentration of Mg and Si ions released in 7 days extracts were shown in Figure 6b.…”

The role of titania on the microstructure, biocorrosion and mechanical properties of Mg/HA-based nanocomposites for potential application in bone repair

“…In particular, Mg-based alloys are very promising for biomedical applications [11]. Bio-degradability, mechanical strength and non-toxicity of Mg make them potential for implantations [12][13][14].…”