2019
DOI: 10.1007/s00018-019-03013-8
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Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks

Abstract: The proteostasis network (PN) comprises a plethora of proteins that are dedicated to aid in protein folding; some with over-lapping functions. Despite this, there are multiple pathophysiological states associated with depletion of chaperones. This is counter-intuitive assuming cells have the ability to re-program transcriptional outputs in accordance with its proteostasic limitations. To this effect, we have used S. cerevisiae to understand the route a cell takes as a response when challenged with different pr… Show more

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Cited by 3 publications
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“…The transcriptome data was analyzed with a standard Kallisto pipeline as described previously 45 . Briefly, fastq files were trimmed using Trimmomatic and the fastqc files were aligned to the yeast transcriptome using Kallisto Reduction, alkylation and In-gel trypsin digestion was done as described in Shevchenko et al…”
Section: Transcriptome Data Analysismentioning
confidence: 99%
“…The transcriptome data was analyzed with a standard Kallisto pipeline as described previously 45 . Briefly, fastq files were trimmed using Trimmomatic and the fastqc files were aligned to the yeast transcriptome using Kallisto Reduction, alkylation and In-gel trypsin digestion was done as described in Shevchenko et al…”
Section: Transcriptome Data Analysismentioning
confidence: 99%