Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

Varol, Ayşegül; Sezen, Serap; Evcimen, Dilhan; Zarepour, Atefeh; Ulus, Gönül; Zarrabi, Ali; Badr, Gamal; Daştan, Sevgi Durna; Orbayoğlu, Asya Gülistan; Selamoğlu, Zeliha; Varol, Mehmet

doi:10.1080/15569543.2021.2024576

Cited by 8 publications

(7 citation statements)

References 113 publications

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“…Studies have shown that BV has anti-cancer efficacy against prostate cancer cells, hepatocellular cancer cells, lung cancer cells, mammary cancer cells, bladder cancer cells, ovarian cancer cells, leukemia, and melanocyte cancer cells ( Liu Cui-Cui et al, 2016 , Rady et al, 2017 , Abd El-Wahed et al, 2019 , Wehbe et al, 2019 , Varol et al, 2022 ). In lung cancer cells, BV causes apoptosis by activating the DRs’ (death receptor 3) ( Rady et al, 2017 ).…”

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

“…Also, melittin causes apoptosis in leukemia cells (U937 cells) via the suppression of Akt (protein kinase B) signal processes ( Gajski and Garaj-Vrhovac, 2008 , Bellik, 2015 , Rady et al, 2017 , Moga et al, 2018 ). Bee venom treatment also downregulated Bcl-2 (B-cell lymphoma 2) which limits the initiation of caspase-3 and cells reinstated their viability in leukemic cells ( Varol et al, 2022 ). Furthermore, melittin inhibits calmodulin (calcium-binding protein) which restrains the progress of leukemia cells in the human body ( Son et al, 2007 , Liu Cui-Cui et al, 2016 ).…”

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

“…Similarly, the apamin acts as an anti - inflammatory agent which stops inflammation of foot edema in animal models induced by dextran and serotonin hypodermically ( Chen and Lariviere, 2010 , Bellik, 2015 ). Due to its anti-inflammatory activity, apamin also restrains phospholipase A2 and COX −2 ( Varol et al, 2022 ). Studies have shown that BV contains anti - inflammatory activity against various diseases.…”

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

See 2 more Smart Citations

Pharmacological properties and therapeutic potential of honey bee venom

Ullah¹,

Aldakheel²,

Anjum³

et al. 2023

Saudi Pharmaceutical Journal

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Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological properties and therapeutic potential of honey bee venom

Ullah¹,

Aldakheel²,

Anjum³

et al. 2023

Saudi Pharmaceutical Journal

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“…Bee venom, often called apitoxin, is a complicated substance secreted by the bee venom gland, located in the abdominal cavity of bees, and injected into victims using a stinger. It may lead to localized inflammation and start a body’s immunological reaction [ 7 ]. The primary components of bee venom are amphipathic polycationic peptides, like amines and melittins, enzymes (phosphatase A2), and low-molecular-weight substances, such as active amines.…”

Section: Introductionmentioning

confidence: 99%

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Pandey

Khan

et al. 2023

Nutrients

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Apitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human health. Thus, this review is targeted toward recapitulating the chemo-preventive potential of melittin (MEL), which constitutes a substantial portion of honeybee venom. Honeybee venom (apitoxin) is produced in the venom gland of the honeybee abdomen, and adult bees utilize it as a primary colony defense mechanism. Apitoxin comprises numerous biologically active compounds, including peptides, enzymes, amines, amino acids, phospholipids, minerals, carbohydrates, and volatile components. We are mainly focused on exploring the potential of melittin (a peptide component) of bee venom that has shown promising potential in the treatment of several human cancers, including breast, stomach, lung, prostate, ovary, kidney, colon, gastric, esophageal, cervical cancers, melanoma, osteosarcoma, and hepatocellular carcinoma. This review has summarized all potential studies related to the anticancerous efficacy of melittin (apitoxin), its formulations, conjugates, and nano-formulations against several human carcinomas, which would further pave the way for future researchers in developing potent drugs for cancer management.

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“…Bee venom acts as apitoxin or biotoxin prepared by bee glands and secreted in the abdominal cavity of bees. It was also found to be effective in the treatment of different types of cancers, with effects such as cancer cell proliferation inhibition, induction of apoptosis, cytotoxicity, and necrosis [13]. Propolis, commonly known as bee glue, is made up of pollen, essential oils, waxes, resins, and various organic substances, including minerals, amino acids, flavonoids, polyphenols, ethanol, and different vitamins.…”

Section: Introductionmentioning

confidence: 99%

General Nutritional Profile of Bee Products and Their Potential Antiviral Properties against Mammalian Viruses

et al. 2022

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Bee products have been extensively employed in traditional therapeutic practices to treat several diseases and microbial infections. Numerous bioactive components of bee products have exhibited several antibacterial, antifungal, antiviral, anticancer, antiprotozoal, hepatoprotective, and immunomodulatory properties. Apitherapy is a form of alternative medicine that uses the bioactive properties of bee products to prevent and/or treat different diseases. This review aims to provide an elaborated vision of the antiviral activities of bee products with recent advances in research. Since ancient times, bee products have been well known for their several medicinal properties. The antiviral and immunomodulatory effects of bee products and their bioactive components are emerging as a promising alternative therapy against several viral infections. Numerous studies have been performed, but many clinical trials should be conducted to evaluate the potential of apitherapy against pathogenic viruses. In that direction, here, we review and highlight the potential roles of bee products as apitherapeutics in combating numerous viral infections. Available studies validate the effectiveness of bee products in virus inhibition. With such significant antiviral potential, bee products and their bioactive components/extracts can be effectively employed as an alternative strategy to improve human health from individual to communal levels as well.

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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

Cited by 8 publications

References 113 publications

Pharmacological properties and therapeutic potential of honey bee venom

Pharmacological properties and therapeutic potential of honey bee venom

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

General Nutritional Profile of Bee Products and Their Potential Antiviral Properties against Mammalian Viruses

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