Cellular therapy and tissue engineering for cartilage repair

Zelinka, Alena; Roelofs, Anke J.; Kandel, Rita A.; Bari, Cosimo De

doi:10.1016/j.joca.2022.07.012

Cited by 39 publications

(32 citation statements)

References 190 publications

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“…To create functional replacements for injured tissues, tissue engineering combines the principles of biology and engineering. One of the main research directions in tissue engineering is the regulation of cell fate [1]. Multiple environmental signals, including biochemical stimuli, mechanical forces, biomaterial characteristics, scaffold properties and extracellular matrix properties, work together to promote tissue formation [2].…”

Section: Introductionmentioning

confidence: 99%

Progress in biomechanical stimuli on the cell-encapsulated hydrogels for cartilage tissue regeneration

Taheri

Ghazali

et al. 2023

Biomater Res

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Background Worldwide, many people suffer from knee injuries and articular cartilage damage every year, which causes pain and reduces productivity, life quality, and daily routines. Medication is currently primarily used to relieve symptoms and not to ameliorate cartilage degeneration. As the natural healing capacity of cartilage damage is limited due to a lack of vascularization, common surgical methods are used to repair cartilage tissue, but they cannot prevent massive damage followed by injury. Main body Functional tissue engineering has recently attracted attention for the repair of cartilage damage using a combination of cells, scaffolds (constructs), biochemical factors, and biomechanical stimuli. As cyclic biomechanical loading is the key factor in maintaining the chondrocyte phenotype, many studies have evaluated the effect of biomechanical stimulation on chondrogenesis. The characteristics of hydrogels, such as their mechanical properties, water content, and cell encapsulation, make them ideal for tissue-engineered scaffolds. Induced cell signaling (biochemical and biomechanical factors) and encapsulation of cells in hydrogels as a construct are discussed for biomechanical stimulation-based tissue regeneration, and several notable studies on the effect of biomechanical stimulation on encapsulated cells within hydrogels are discussed for cartilage regeneration. Conclusion Induction of biochemical and biomechanical signaling on the encapsulated cells in hydrogels are important factors for biomechanical stimulation-based cartilage regeneration.

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Section: Introductionmentioning

confidence: 99%

Progress in biomechanical stimuli on the cell-encapsulated hydrogels for cartilage tissue regeneration

Taheri

Ghazali

et al. 2023

Biomater Res

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“…The current surgical transplantation treatment has its limitations. For example, autologous transplantation has a limited repair range and does not prevent the development of OA, and allogeneic transplantation is limited by the donor, which may lead to low graft fusion and disease transmission [46]. Currently, an injectable gel is the main development direction of cartilage tissue engineering (TE).…”

Section: Sf Hydrogels For Cartilagementioning

confidence: 99%

“…In addition, the affected articular surface of OA is larger, and the articular homeostasis is altered, which may enhance implant degradation. OA is often associated with obesity and age, and implant therapy is also affected [46] (Table 1).…”

Section: Sf Hydrogels For Cartilagementioning

confidence: 99%

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Lyu

Liu

et al. 2023

Gels

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Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the Bombyx mori through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability, low immunogenicity, and tunability, making it a versatile material widely applied in biological fields, particularly in tissue engineering. In tissue engineering, SF is often fabricated into hydrogel form, with the advantages of added materials. SF hydrogels have mostly been studied for their use in tissue regeneration by enhancing cell activity at the tissue defect site or counteracting tissue-damage-related factors. This review focuses on SF hydrogels, firstly summarizing the fabrication and properties of SF and SF hydrogels and then detailing the regenerative effects of SF hydrogels as scaffolds in cartilage, bone, skin, cornea, teeth, and eardrum in recent years.

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“…The first try to repair cartilaginous tissue utilizing tissue engineering was published in 1977. Since then, cell-based procedures have been used in orthopedic surgery [13]. There are a number of elements implicated in cellular treatment and tissue engineering for the repair of cartilaginous tissue.…”

Section: Basic Conceptsmentioning

confidence: 99%

Molecular Mechanisms of Cartilage Repair and Their Possible Clinical Uses: A Review of Recent Developments

Rodríguez-Merchán

2022

IJMS

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Articular cartilage (AC) defects are frequent but hard to manage. Osteoarthritis (OA) is a musculoskeletal illness that afflicts between 250 and 500 million people in the world. Even though traditional OA drugs can partly alleviate pain, these drugs cannot entirely cure OA. Since cartilaginous tissue of the joints has a poor self-repair capacity and very poor proliferative ability, the healing of injured cartilaginous tissue of the joint has not been accomplished so far. Consequently, the discovery of efficacious mediations and regenerative treatments for OA is needed. This manuscript reviews the basic concepts and the recent developments on the molecular mechanisms of cartilage repair and their potential clinical applications. For this purpose, a literature exploration was carried out in PubMed for the years 2020, 2021, and 2022. On 31 October 2022 and using “cartilage repair molecular mechanisms” as keywords, 41 articles were found in 2020, 42 in 2021, and 36 in 2022. Of the total of 119 articles, 80 were excluded as they were not directly related to the title of this manuscript. Of particular note are the advances concerning the mechanisms of action of hyaluronic acid, mesenchymal stem cells (MSCs), nanotechnology, enhancer of zeste 2 polycomb repressive complex 2 subunit (EHZ2), hesperetin, high mobility group box 2 (HMGB2), α2-macroglobulin (α2M), proteoglycan 4 (Prg4)/lubricin, and peptides related to cartilage repair and treatment of OA. Despite the progress made, current science has not yet achieved a definitive solution for healing AC lesions or repairing cartilage in the case of OA. Therefore, further research into the molecular mechanisms of AC damage is needed in the coming decades.

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Cellular therapy and tissue engineering for cartilage repair

Cited by 39 publications

References 190 publications

Progress in biomechanical stimuli on the cell-encapsulated hydrogels for cartilage tissue regeneration

Progress in biomechanical stimuli on the cell-encapsulated hydrogels for cartilage tissue regeneration

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Molecular Mechanisms of Cartilage Repair and Their Possible Clinical Uses: A Review of Recent Developments

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