Cellular uptake of metal oxide-based nanocomposites and targeting of chikungunya virus replication protein nsP3

Bhatia, Pooja; Singh, Vedita Anand; Rani, Ruchi; Nath, Mala; Tomar, Shailly

doi:10.1016/j.jtemb.2023.127176

Cited by 2 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on conformer and pharmacophore, Tomar and his team at the IITR discovered the peptidomimetic inhibitors of CHIKV-nsP2 protease. The molecular docking of the nsP3/4 junction peptide at the CHIKV nsP2 protease active site gave structural insight into the nsP3/4 peptide’s likely mode of binding and identified key molecular interactions for the substrate binding mode [ 182 , 183 , 184 ]. Besides, they showed that the peptidomimetic inhibitors Pep-I and Pep-II target virus-specific cysteine protease for CHIKV suppression [ 185 ].…”

Section: Chikv Research: Indian Scenariomentioning

confidence: 99%

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

et al. 2023

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is an infectious agent spread by mosquitos, that has engendered endemic or epidemic outbreaks of Chikungunya fever (CHIKF) in Africa, South-East Asia, America, and a few European countries. Like most tropical infections, CHIKV is frequently misdiagnosed, underreported, and underestimated; it primarily affects areas with limited resources, like developing nations. Due to its high transmission rate and lack of a preventive vaccine or effective treatments, this virus poses a serious threat to humanity. After a 32-year hiatus, CHIKV reemerged as the most significant epidemic ever reported, in India in 2006. Since then, CHIKV-related research was begun in India, and up to now, more than 800 peer-reviewed research papers have been published by Indian researchers and medical practitioners. This review gives an overview of the outbreak history and CHIKV-related research in India, to favor novel high-quality research works intending to promote effective treatment and preventive strategies, including vaccine development, against CHIKV infection.

show abstract

Section: Chikv Research: Indian Scenariomentioning

confidence: 99%

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

et al. 2023

View full text Add to dashboard Cite

show abstract

Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles

Fernández-Trujillo,

Jiménez-Moreno,

Rodríguez-Fariñas

et al. 2024

Anal Bioanal Chem

View full text Add to dashboard Cite

The extensive application of metallic nanoparticles (NPs) in several fields has significantly impacted our daily lives. Nonetheless, uncertainties persist regarding the toxicity and potential risks associated with the vast number of NPs entering the environment and human bodies, so the performance of toxicological studies are highly demanded. While traditional assays focus primarily on the effects, the comprehension of the underlying processes requires innovative analytical approaches that can detect, characterize, and quantify NPs in complex biological matrices. Among the available alternatives to achieve this information, mass spectrometry, and more concretely, inductively coupled plasma mass spectrometry (ICP-MS), has emerged as an appealing option. This work critically reviews the valuable contribution of ICP-MS-based techniques to investigate NP toxicity and their transformations during in vitro and in vivo toxicological assays. Various ICP-MS modalities, such as total elemental analysis, single particle or single-cell modes, and coupling with separation techniques, as well as the potential of laser ablation as a spatially resolved sample introduction approach, are explored and discussed. Moreover, this review addresses limitations, novel trends, and perspectives in the field of nanotoxicology, particularly concerning NP internalization and pathways. These processes encompass cellular uptake and quantification, localization, translocation to other cell compartments, and biological transformations. By leveraging the capabilities of ICP-MS, researchers can gain deeper insights into the behaviour and effects of NPs, which can pave the way for safer and more responsible use of these materials. Graphical abstract

show abstract

Cellular uptake of metal oxide-based nanocomposites and targeting of chikungunya virus replication protein nsP3

Cited by 2 publications

References 63 publications

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles

Contact Info

Product

Resources

About