Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery

Abstract

The use of water-soluble polymers of natural, semisynthetic, and synthetic origin for dermal and transdermal drug delivery systems is manifold. Among the most used biopolymers in the formulation of skin preparations, the cellulose ether derivatives as representatives of semisynthetic polymers distinguish through their specific physicochemical properties, by which the pharmacist can select the appropriate cellulose derivative for a particular purpose. The hydrogels containing cellulose derivatives as gelling agents are widely used as water-soluble ointment bases, because they usually associate the characteristics of both conventional and innovative hydrogels, including especially safety, biocompatibility, biodegradability, and a relatively easy way of preparation and low price. The present chapter describes the following issues: the physicochemical properties of water-soluble cellulose derivatives in relationship with their type and grade; physical and chemical properties of cellulose-derivatives-based hydrogels and their compatibility with other auxiliary substances commonly used in the formulation of pharmaceutical hydrogels; the development and manufacturing of these hydrogels on both small and large scales; the characterization of cellulose derivatives hydrogels as pharmaceutical dosage forms through different compendial and noncompendial methods; and well-recognized and novel applications of cellulosederivatives-based hydrogels for dermal and transdermal drug delivery.

Cellulose-based hydrogel materials: chemistry, properties and their prospective applications

“…Ahmadi et al ( 2015 ) mentioned multi-dimensional drug delivery system of chitosan-based hydrogels for oral, ocular and nasal drug delivery. For dermal and transdermal drug delivery systems, use of cellulose-derivatives-based hydrogels have been elucidated by Vlaia et al ( 2016 ). Target protein delivery using Fe 3 O 4 nanoparticles in the regenerated cellulose microspheres is developed by establishing magnetic-induced transference (Luo et al 2009 ).…”

Effect of Na2CO3 on the Microstructure and Macroscopic Properties and Mechanism Analysis of PVA/CMC Composite Film

“…Biopolymers are considered as an ideal alternative to traditional plastic materials owing to their advantages such as biodegradability, nontoxicity, and potential widespread applications; at present, a lot of research is focused on biodegradable materials. Among the biopolymers, cellulose and its water-soluble derivatives are mostly preferred because of the abundance of cellulose on earth and relatively low cost of cellulose derivatives compared to synthetic polymers [1].…”

Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV

“…Since it is a semi-synthetic polymer, the cellulose can be modified by substituting different functional groups in order to obtain a wide variety of polymers (hydroxypropylmethyl cellulose (HPMC), methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, ethyl cellulose, etc. ), all of which can be used to prepare vaginal gels, depending on the desired characteristics in the formulation [20][21][22].…”