Cellulose nanoparticles are a biodegradable photoacoustic contrast agent for use in living mice

Jokerst, Jesse V.; Sompel, Dominique Van de; Bohndiek, Sarah E.; Gambhir, Sanjiv S.

doi:10.1016/j.pacs.2014.07.001

Cited by 48 publications

(27 citation statements)

References 49 publications

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“…Other examples of organic NPs consisting e.g. of cellulose [161] or melanin [162, 163] have been also shown to create usable optoacoustic contrast.…”

Section: Dynamic Contrast Enhancement Approachesmentioning

confidence: 99%

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

et al. 2017

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Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.

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“…Other examples of organic NPs consisting e.g. of cellulose [161] or melanin [162, 163] have been also shown to create usable optoacoustic contrast.…”

Section: Dynamic Contrast Enhancement Approachesmentioning

confidence: 99%

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

et al. 2017

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“…Recently, the use of cellulose-based nanoparticles has been explored in PA applications to improve imaging capability. CNC-based composite enhanced PA signals in live mice and was also able to undergo biodegrading ex vivo in the presence of a naturally occurring enzyme (Jokerst et al, 2014). Although CNCs are biocompatible, nontoxic to the human body, and enhance imaging potential, their use has yet to be expanded.…”

Section: Bioimaging: "Green" Contrast Agentsmentioning

confidence: 99%

Cellulose Nanocrystals as Advanced "Green" Materials for Biological and Biomedical Engineering

Sinha¹,

Martin²,

Lim³

et al. 2015

Journal of Biosystems Engineering

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Background: Cellulose is a ubiquitous, renewable and environmentally friendly biopolymer, which has high promise to fulfil the rising demand for sustainable and biocompatible materials. Particularly, the recent progress in the synthesis of highly crystalline cellulose-based nanoscale biomaterials, namely cellulose nanocrystals (CNCs), draws significant attention from many research communities, ranging from bioresource engineering, to materials science and engineering, to biological and biomedical engineering to bionanotechnology. The feasibility of harnessing CNCs' unique biophysicochemical properties has inspired their basic and applied research, offering much promise for new biomaterials with diverse advanced functionalities. Purpose: This review focuses on vital issues and topics on the recent advances in CNC-based biomaterials with potential, in particular, for bionanotechnology and biological and biomedical engineering. The challenges and limitations of CNC technology are discussed as well as potential strategies to overcome them, providing an essential source of information in the exploration of possible and futuristic applications of the CNC-based functional "green" nanomaterials. Conclusion: CNCs offer exciting possibilities for advanced "green" nanomaterials, driving innovative research and development in a wide range of fields, including biological and biomedical engineering.

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“…The NP group includes gold, gold/silica hybrids, carbon, porphysomes, iron oxide and copper sulfide. If there are any concerns about the actual US-guided material, they are based on the physical properties which result in a significant non-specific and long-term liver and spleen accumulation [106].…”

Section: Nanoparticles Modulated By Ultrasound (Us)mentioning

confidence: 99%