Centella asiatica Extract Loaded BSA Nanoparticles Using the Organic and Conventional C. asiatica to Improve Bioavailability Activity and Drug Delivery System

Huang, Ming-Shan; Chanapongpisa, Patteera; Yasurin, Patchanee; Kitsubthawee, Kanyarat; Phetsom, Jirapa; Lindayani, I Komang

doi:10.14416/j.asep.2020.01.001

Cited by 5 publications

(8 citation statements)

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“…Nanotechnology indicates a high potential for the development of functional foods, without affecting consumer perception and improving the uptake of individual components. Recently, there are considerable interests in developing high-performance delivery vehicles to protect bioactive compounds, improve bioactive compound bioavailability for improving drug delivery to the target, and enhancing the stability of active chemicals for drug formulation (Huang et al, 2020).…”

Section: Encapsulation Has Been Proposed As An Effective Techniquementioning

confidence: 99%

“…Zein has several properties allowing it to self-assemble into different structures such as film, sponges, and spheres (Wang & Padua, 2010). In the pharmaceutical and food areas, zein shows a high potential for application as a biomaterial for the nano-encapsulation of bioactive compounds with the ability to provide moisture, an oxygen barrier, and high thermal resistance (Huang et al, 2020).…”

Section: Encapsulation Has Been Proposed As An Effective Techniquementioning

confidence: 99%

“…Zein has several properties allowing it to self‐assemble into different structures such as film, sponges, and spheres (Wang & Padua, 2010). In the pharmaceutical and food areas, zein shows a high potential for application as a biomaterial for the nano‐encapsulation of bioactive compounds with the ability to provide moisture, an oxygen barrier, and high thermal resistance (Huang et al., 2020). Zein can assist the control release of encapsulated hydrophobic compound such as polyphenols, vitamins, and omega‐three fatty acids into nonaqueous environment and prolong its shelf life (Donsì et al., 2017; Wu et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of gamma oryzanol loaded zein nanoparticles and its improved stability

Rodsuwan

Pithanthanakul

Thisayakorn

et al. 2020

Food Science & Nutrition

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Gamma oryzanol (GO), a bioactive ingredient found in rice bran oil, performs a variety of biological effects such as antioxidant activity, reduction of total cholesterol, anti‐inflammation, and antidiabetes. However, GO is water‐insoluble and normally degrades through oxidation. Thus a nano‐encapsulation technique was investigated to improve its stability and quality. In this research, gamma oryzanol was successfully encapsulated into zein nanoparticles. The fabrication parameters including pH, zein concentration (0.3, 0.4, and 0.5% w/v), and % GO loading (30, 40, and 50% by weight) were investigated. Particle size, zeta potential, yield, encapsulation efficiency and the stability or GO retention during the storage were determined. The morphology of gamma oryzanol loaded zein nanoparticles (GOZNs) was observed by scanning electron micrographs and transmission electron microscope. The increase of zein concentration and % GO loading resulted to an increase of yield, encapsulation efficiency, and particle size. The particle size of the GOZNs ranged from 93.24–350.93, and 144.13–833.27, and 145.27–993.13 nm for each zein concentration with 3 loading levels, respectively. Nano‐encapsulation exhibited higher % GO retention compared with nonencapsulated GO during 60 days storage both at 4°C and −18°C. In vitro study indicated the sustained release of GO in the simulated gastric fluid followed by simulated intestinal fluid. This finding indicated a high potential for the application of insoluble GO with improved stability by encapsulation with the hydrophobic zein protein.

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Section: Encapsulation Has Been Proposed As An Effective Techniquementioning

confidence: 99%

Section: Encapsulation Has Been Proposed As An Effective Techniquementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and characterization of gamma oryzanol loaded zein nanoparticles and its improved stability

Rodsuwan

Pithanthanakul

Thisayakorn

et al. 2020

Food Science & Nutrition

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“…347 Moreover, the incorporation of innovative biomaterials and bioengineering techniques may facilitate the development of multifunctional scaffolds or dressings capable of simultaneously providing structural support, promoting tissue regeneration, and delivering AC in a controlled manner. 348 Additionally, combining AC with other bioactive agents or growth factors within nanocarriers could potentially create synergistic therapeutic effects, accelerating wound closure, reducing inflammation, and minimizing scar formation. 349 As research progresses, addressing challenges related to standardization, scalability, safety, and regulatory aspects will be pivotal in translating the AC-nanotechnology-driven approaches from bench to bedside.…”

Section: Future Prospectivementioning

confidence: 99%

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar,

Mahmood

et al. 2024

RSC Pharm.

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“…Several techniques such as capsules, solid dispersion, dry emulsion, pellets and tablets, microsphere, nanoparticles, suppositories, and implants are applied to improve the efficiency of drugs [13]. Formulations of bioactive compounds with carriers molecules, such as polylactic-co-glycolic acid (PLGA), Bovine Serum Albumin (BSA), and Gelatin, in nanomolecular scale are conducted to improve bioavailability and biological activities including antibacterials, antioxidants in in vitro system [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities ofCentella asiaticaExtract-loaded Bovine Serum Albumin Nanoparticles in Simulated Gastrointestinal System Study

et al. 2020

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Bioavailability of active compounds extracted from herbs is generally limited to be adsorbed or expressed to target organisms due to several physical and chemical factors. Nanoparticle encapsulation techniques was developed to carry bioactive macromolecules of Centella asiatica (Buabok) in the form of C. asiatica Extract-loaded Bovine Serum Albumin Nanoparticles (CBNPs) to improve bioavailability. In this study, the antioxidant activities of CBNPs and C. asiatica crude extract were evaluated by using DPPH radical scavenging assay in the simulated gastrointestinal system, including mastication, stomach, duodenum, and ileum conditions to provide the environment which similar to in vivo system in terms of chemical and physical parameters. CBNPs were prepared by mixing of C. asiatica crude extract and BSA at different ratio of 1:2, 1:3, and 1:4. The results showed that the highest antioxidant activity of CBNP was observed when the ratio of crude extract and BSA at 1:2 was used at pH 2.0 or in the simulated stomach condition. The denaturation or unfolding of BSA in the simulated stomach occurred when pH was low could lead to the release of active compounds at certain area in gastrointestinal system.

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Centella asiatica Extract Loaded BSA Nanoparticles Using the Organic and Conventional C. asiatica to Improve Bioavailability Activity and Drug Delivery System

Cited by 5 publications

References 0 publications

Preparation and characterization of gamma oryzanol loaded zein nanoparticles and its improved stability

Preparation and characterization of gamma oryzanol loaded zein nanoparticles and its improved stability

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Antioxidant Activities ofCentella asiaticaExtract-loaded Bovine Serum Albumin Nanoparticles in Simulated Gastrointestinal System Study

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