Centenarians as Stem Cell Donors

Lewis, Reina; Жданов, Р. И.

doi:10.1080/15265160903320554

Cited by 3 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proposed that centenarians and supercentenarians (aged 110 years or more) may present an unprecedented opportunity to explore the possibilities of SCs that have proven their value over time. These SCs should be studied to determine their developmental potential, mutational load, telomere lengths, and markers of "stemness" [291]. In conclusion, beyond the great enthusiasm for new treatment perspectives, an heavy investigational work is still in progress to develop specific SCs related pharmacology.…”

Section: Discussionmentioning

confidence: 99%

Stem cells in clinical practice: applications and warnings

Lodi

Iannitti

Palmieri

2011

J Exp Clin Cancer Res

170

113

View full text Add to dashboard Cite

Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area, with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy.MethodsWe have searched Pubmed/Medline for clinical trials, involving the use of human stem cells, using the key words "stem cells" combined with the key words "transplantation", "pathology", "guidelines", "properties" and "risks". All the relevant clinical trials have been included. The results have been divided into different categories, basing on the way stem cells have been employed in different pathological conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Stem cells in clinical practice: applications and warnings

Lodi

Iannitti

Palmieri

2011

J Exp Clin Cancer Res

170

113

View full text Add to dashboard Cite

show abstract

Ethical and scientific aspects of human embryonic material research: the Great Britain regulations

Rybtsov,

Dumacheva,

Dumachev

et al. 2016

Genes & Cells

View full text Add to dashboard Cite

We analyze the ethical and scientific issues of human embryonic specimen and its utilization for research purposes. Human embryonic specimens are the source of stem cells which are the foundation for all organs and tissue formation. The analysis of human embryonic specimens promises to obtain the essential knowledge about human development and reveal the causes of human development pathology. Ethical and scientific problems of human embryonic specimens donation and research are debated here We review the impact that human embryonic specimens impose on scientific research, usage restrictions, risk assessment, research personnel and donor protection in view of the British, and other European publications, case reports, legislation, regulations and guidelines This work is focused on the discussion of different aspects of donation and usage of human embryonic specimens obtained after the elective medical termination of pregnancy We discuss suggestions for improvement of the ethical and scientific regulations for the work with human embryonic donor material in Russian Federation.

show abstract

Inflammation and Genetics: An Insight in the Centenarian Model

Iannitti

Palmieri

2011

Human Biology

View full text Add to dashboard Cite

The number of centenarians is growing worldwide. This specific cohort has aroused the attention of scientists worldwide and is considered one of the most valuable models to study the mechanisms involved in the aging process. In fact, they have reached the extreme limits of human life span and, most important of all, they show relatively good health being able to perform their routine daily life. Because they have escaped the common lethal diseases, the role of their genetic background has been brought into focus. In fact, sequence variations, in a variety of pro- or anti-inflammatory cytokine genes, have been found to influence successful ageing and longevity. The key role played by cytokines has been also confirmed in centenarians as we know that inflammation has been related to several pathological burdens (e.g., obesity, atherosclerosis, and diabetes). Successful ageing seems to be related to an optimal functioning of the immune system, pointing out that polymorphisms for the immune system genes, which are involved in the regulation of immune-inflammatory responses, may play a key role in the genetics of ageing. This review provides an update in the field of ageing related to inflammation and genetics.

show abstract

Centenarians as Stem Cell Donors

Cited by 3 publications

References 10 publications

Stem cells in clinical practice: applications and warnings

Stem cells in clinical practice: applications and warnings

Ethical and scientific aspects of human embryonic material research: the Great Britain regulations

Inflammation and Genetics: An Insight in the Centenarian Model

Contact Info

Product

Resources

About