Central Adiposity Rather Than Total Adiposity Measurements Are Specifically Involved in the Inflammatory Status from Healthy Young Adults

Abstract

This study assessed the potential association of some proinflammatory markers with adiposity (total vs. central) and metabolic features in young adults. Measurements included body composition, lifestyle features, blood biochemical, and selected inflammatory indicators on 154 healthy subjects (53 M/101 F; 21.5 ± 3 years; 22.1 ± 2.6 kg/m(2)). Those subjects with higher waist circumference (WC) and waist-hip ratio (WHR) showed higher (P < 0.05) C-reactive protein (CRP), complement C3, interleukin-6 (IL6), and retinol binding protein-4 (RBP4) concentrations, while only IL6 was positively associated with total body fat (%). Furthermore, CRP and RBP4 were higher in former/current smokers, as compared to never smokers (P < 0.05). Some indicators of glucose (homeostasis model assessment-insulin resistance) and lipid metabolism (total cholesterol/high density lipoprotein-cholesterol and triglycerides) were positively associated with the assayed inflammatory markers (P < 0.05). The findings of this cross-sectional study indicate that central adiposity-related indicators (WC/WHR) correlated better than those assessing total adiposity with plasma proinflammatory markers, which additionally were associated with lifestyle and metabolic features in healthy young adults.

Determinants of C-reactive protein concentrations in pregnant women with type 1 diabetes

“…This provides additional evidence for an association between central adiposity and elevated CRP levels. 24 Our results also suggest that central, rather than total, adiposity might be the major determinant of inflammatory status, which was previously demonstrated by Hermsdorff et al 25 in healthy young adults. Important data regarding the association between CRP levels in pregnancy and maternal obesity come from a cross-sectional study of Retnakaran et al, 26 carried out in healthy women and those with gestational diabetes.…”

The Association between Anti-Nuclear Antibodies and Obesity is Likely Mediated by Abdominal Adiposity and Systemic Inflammation

“…As has been previously reported, in our study obese participants had elevated levels of inflammation as measured by CRP at baseline [20,21]. Therefore when evaluating the association between obesity and ANA positivity it is imperative to consider the role of inflammation given that it is typically inflammatory conditions such as lupus that induce ANA positivity.…”

“…A major difference between the two groups is body habitus where those with the metabolic syndrome have higher rates of abdominal adiposity [19]. Central adiposity has been shown to be associated with higher rates of C-reactive protein (CRP), a common measure of systemic inflammation, in all age groups as well as in people with normal BMI who have higher abdominal fat deposits [20][21][22].…”

RBP4: a controversial adipokine

“…Omental adipose tissue is an important source of RBP4 in severely obese patients (39). In a recent study, higher waist circumference and waist-to-hip ratio were associated with higher RBP4 levels and markers of systemic inflammation (41).…”