Central African Lymphomas

Hutt, M. S. R.; Wright, D. H.

doi:10.1016/s0140-6736(63)91113-9

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…2 Includes countries with at least 30 total cases. 3 Rates per million person-years, age-adjusted using the 1960 Segi world standard. 4 Incidence rate ratio compared to rates of US white people.…”

Section: Worldwide Geographic Patterns Of Blmentioning

confidence: 99%

“…Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma of germinal center B cells [1], first described as a jaw sarcoma in Ugandan children by Denis Burkitt in 1958 [2]. The pathology of BL was defined as a diffuse infiltration of medium-sized lymphoid cells, with pale staining macrophages giving a "starry-sky" appearance under the microscope [3,4]. This pathology definition enabled the epidemiology and clinical behavior of BL cases to be studied worldwide [5][6][7][8], at different anatomic sites [4,9,10], and from periods predating Burkitt's report [11].…”

Section: Introductionmentioning

confidence: 99%

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Burkitt Lymphoma Incidence in Five Continents

Mbulaiteye

Devesa

2022

Hemato

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Burkitt lymphoma (BL) is a rare non-Hodgkin lymphoma first described in 1958 by Denis Burkitt in African children. BL occurs as three types, endemic, which occurs in Africa and is causally attributed to Epstein-Barr virus and P. falciparum infections; sporadic, which occurs in temperate areas, but the cause is obscure; and immunodeficiency-type, which is associated with immunosuppression. All BL cases carry IG∷MYC chromosomal translocations, which are necessary but insufficient to cause BL. We report a comprehensive study of the geographic, sex, and age-specific patterns of BL among 15,122 cases from Cancer Incidence in Five Continents Volume XI for 2008–2012 and the African Cancer Registry Network for 2018. Age-standardized BL rates were high (>4 cases per million people) in Uganda in Africa, and Switzerland and Estonia in Europe. Rates were intermediate (2–3.9) in the remaining countries in Europe, North America, and Oceania, and low (<2) in Asia. Rates in India were 1/20th those in Uganda. BL rates varied within and between regions, without showing a threshold to define BL as endemic or sporadic. BL rates were twice as high among males as females and showed a bimodal age pattern with pediatric and elderly peaks in all regions. Multi-regional transdisciplinary research is needed to elucidate the epidemiological patterns of BL.

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Section: Worldwide Geographic Patterns Of Blmentioning

confidence: 99%