Central and peripheral neurological complications of primary Sjögren's syndrome

Fauchais, Anne-Laure; Magy, Laurent; Vidal, É.

doi:10.1016/j.lpm.2012.06.002

Cited by 66 publications

(75 citation statements)

References 65 publications

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“…Focal symptoms include sensorial and motor deficits, brainstem syndrome, movement disorders, cerebellum syndrome, seizures, and migraine. Nonfocal symptoms include encephalopathy, aseptic meningitis, cognitive dysfunction, dementia, and psychiatric disorders 2 . No consensus has been reached about the most common CNS manifestations of this disease.…”

Section: Discussionmentioning

confidence: 99%

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A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: To investigate cognitive deficits in patients with primary Sjögren's syndrome (PSS). Method: Eighteen patients with PSS, aged between 25 and 61 years, were subjected to a short neuropsychological battery and compared with 18 patients with multiple sclerosis and 18 healthy controls. Results: The analysis of variance (ANOVA) revealed that the clinical groups had significantly worse performance than the control group on the Rey Auditory Verbal Learning Test 3; (F 2,53 =3.500, p=0.038) and 7 (F 2,53 =5.068, p=0.010). The clinical groups had elevated levels of depression on the Beck Depression Inventory (BDI); (p=0.003). The analysis of the data from the Trail Making Test B-A revealed a significant difference between the clinical and control groups (p=0.023). The analysis of covariance with BDI score as a covariate, did not change the outcome. Conclusion: Our study revealed cognitive deficits in patients with PSS detectable by a short neuropsychological battery.Keywords: neuropsychological evaluation; Sjögren's syndrome, cognitive impairment, neuropsychology. Primary Sjögren's syndrome (PSS) is an inflammatory autoimmune disease characterized by infiltration of exocrine glands. It occurs without an association with other connective tissue diseases and affects mainly salivary and lachrymal glands, causing xerostomy and keratoconjunctivitis sicca 1,2 . It often afflicts middle-age women, with an estimated prevalence of 2% in the adult population 3 . Moreover, PSS can be associated with impairments of the nervous system. In the central nervous system (CNS), the focal and nonfocal involvement of the brain and spinal cord has been described, resulting in a wide spectrum of neurological, psychiatric, and cognitive symptoms 4 .Cognitive impairments in patients with PSS were reported by Malinow 5 and later confirmed by other studies 6,7 . In Brazil, we have not found any case-series studies that have investigated cognitive impairments in PSS. We found one case report 8 .The results from other countries suggest that patients with PSS display cognitive impairments in attention, memory,

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Section: Discussionmentioning

confidence: 99%

“…It occurs without an association with other connective tissue diseases and affects mainly salivary and lachrymal glands, causing xerostomy and keratoconjunctivitis sicca 1,2 . It often afflicts middle-age women, with an estimated prevalence of 2% in the adult population 3 .…”

mentioning

confidence: 99%

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…[20] MR incelemede genellikle MS benzeri beyaz cevher lezyonlar› görülür. [18] SjS ve SSS tutulumu olan hastalar›n beyin dokusu histopatolojik olarak incelendi¤inde, küçük damarlarda mononükleer enflamasyon ve iskemik hemorajik vaskülopati görülür. [21] Kontrollü çal›flmalar olmamas›na karfl›l›k gözlemsel vaka serilerinde glikokortikoid ve siklofosfamidin yararl› etkileri belirtilmektedir.…”

Section: Optik Nöritunclassified

“…[21] Kontrollü çal›flmalar olmamas›na karfl›l›k gözlemsel vaka serilerinde glikokortikoid ve siklofosfamidin yararl› etkileri belirtilmektedir. [18] SjS hastalar›nda tromboembolik olaylar daha s›kt›r ve antifosfolipid antikorlarla da ba¤lant›l›d›r ve bu grup olgularda antikoagülan tedaviler daha ön planda gelmektedir.…”

Section: Optik Nöritunclassified

“…SSS tutulumuna ba¤l› a¤›r kognitif bozukluk ve demans nadirdir ancak steroid tedavisine yan›t veren demans vakalar› da bildirilmifltir. [18] SjS; s›k rastlanan ancak tan› gecikmesinin de s›k yafland›¤› bir hastal›kt›r. Yayg›n, net tan›mlanamayan a¤r›-lar, halsizlik, kognitif bozukluklar, depresyon bulgular›-n›n mekanizmas› tam olarak çözülememifltir.…”

Section: Nöropsikolojik Bulgularunclassified

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