Central auditory processing in parkinsonian disorders: A systematic review

Groote, Evelien De; Keyser, Kim De; Bockstael, Annelies; Botteldooren, Dick; Santens, Patrick; Letter, Miet De

doi:10.1016/j.neubiorev.2020.03.001

Cited by 13 publications

(22 citation statements)

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“…The literature on auditory processing in all clinical disease stages of PD was synthesized for each type of audiological or electrophysiological measurement. Detailed outcomes and results of the systematic review are published elsewhere ( 16 ). Finally, a specific focus was given on the results of “early stage PD” studies.…”

Section: Methodsmentioning

confidence: 99%

“…Altogether, current research has found no evidence for alterations regarding the perception of basic acoustic features in early stage PD. In more advanced PD, psychoacoustic studies suggest that (ab)normal auditory perception is highly dependent on the paradigm that is used (16). More specific, tasks that probe the lower limits of the ability to detect and discriminate auditory changes have demonstrated abnormal results in PD.…”

Section: Central Auditory Testsmentioning

confidence: 99%

“…From a broader point of view, the outcome of the P1-N1-P2 waveform highly depends on the acoustic characteristics of the stimulus, such as frequency, intensity, duration, and location (94). Based on the majority of studies that used an auditory oddball paradigm, no altered auditory P1-N1-P2 complex in patients with PD compared to HCs could be found (16). Significant differences in latency or amplitude values of the different subcomponents have been reported between patients with PD and HCs [e.g., (97)(98)(99)(100)(101)], however, no conclusive pattern of auditory alterations emerged.…”

Section: P1-n1-p2 Complexmentioning

confidence: 99%

“…Based on decreased amplitude values of the Nd in patients with PD, alterations in selective auditory attention in PD have been suggested (79,106,124). However, it remains unclear which aspects of selective auditory attention might be altered in patients with PD, as different results have been reported regarding the early central subcomponent (Nd1) and the late frontal subcomponent (Nd2) (16). The Nd1 may reflect the matching process of incoming auditory stimuli with the internal template, whereas Nd2 is thought to represent the updating of the internal template (125).…”

Section: Processing Negativity or Ndmentioning

confidence: 99%

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Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

et al. 2020

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Research on auditory processing in Parkinson's disease (PD) has recently made substantial progress. At present, evidence has been found for altered auditory processing in the clinical stage of PD. The auditory alterations in PD have been demonstrated with low-cost and non-invasive assessments that are already used in routine clinical practice. Since auditory alterations have been reported early in disease progression, it would be highly relevant to investigate whether auditory markers could be provided in the prodromal stage of PD. In addition, auditory alterations in early stage PD might be modulated by dopaminergic medication. Therefore, the aim of this review is (1) to summarize the literature on auditory processing in PD with a specific focus on the early disease stages, (2) to give future perspectives on which audiological and electrophysiological measurements could be useful in the prodromal stage of PD and (3) to assess the effect of dopaminergic medication on potential auditory markers in the prodromal stage of PD.

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Section: Methodsmentioning

confidence: 99%

Section: Central Auditory Testsmentioning

confidence: 99%

Section: P1-n1-p2 Complexmentioning

confidence: 99%

Section: Processing Negativity or Ndmentioning

confidence: 99%

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Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

et al. 2020

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“…Basal ganglia may affect the temporal auditory processing for complex rhythm (37). The review by De Groote et al (44) also showed impaired temporal processing in patients with Parkinson's disease. TLE is characterized by seizure in the temporal lobe caused by an imbalance between the excitatory and inhibitory (41,42).…”

Section: Strengths Limitations and Suggestions For Further Studiesmentioning

confidence: 99%

Effectiveness of the Auditory Temporal Ordering and Resolution Tests to Detect Central Auditory Processing Disorder in Adults With Evidence of Brain Pathology: A Systematic Review and Meta-Analysis

2021

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Background: Auditory temporal processing tests are key clinical measures in order to diagnose central auditory processing disorder (CAPD). Although these tests have been used for decades, there is no up-to-date evidence to determine the effectiveness of detecting the abnormalities in central auditory processing in adults while the available national CAPD guidelines predominantly address CAPD in the pediatric population.Purpose: To determine the efficacy of the auditory temporal ordering tests [duration pattern test (DPT) and frequency pattern test (FPT)], and a temporal resolution test [gaps-in-noise (GIN) test] for detecting the central auditory processing abnormalities in adults with documented brain pathology.Research Design: Systematic reviews and meta-analyses.Study samples: Four databases, including PubMed, Web of Science, Embase, and Scopus, were systematically searched. The publications in the English language that recruited adults (above 16 years old) with pathologic brain conditions and described the diagnostic tests for auditory temporal processing were selected for review.Data Collections and Analysis: All data were systematically evaluated, extracted, categorized, and summarized in tables. The meta-analysis was done in order to determine the effectiveness of the DPT, FPT, and GIN tests.Results: The results showed significantly poorer performance of DPT and FPT, compared between participants with confirmed brain disease and normal controls, at the mean differences of percent correct −21.93 (95% CI, −26.58 to −17.29) and −31.37 (95% CI, −40.55 to −22.19), respectively. Subjects with brain pathology also performed poorer in GIN test at the mean difference of 3.19 milliseconds (95% CI, 2.51 to 3.87).Conclusion: The results from the meta-analysis provide evidence that DPT, FPT, and GIN clinical measures are effective in the diagnosis of CAPD in adults with neurological disorders. Poor performance on these tests is significantly related to the confirmed brain pathology. However, different units in results presentation and variety of testing strategies are limitations for this meta-analysis. The standard pattern of result reporting and international protocols test strategies should be developed in order to conduct better meta-analyses with a larger collection of suitable studies and less heterogeneity.

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Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

et al. 2021

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There is accumulating evidence for auditory dysfunctions in patients with Parkinson's disease (PD). Moreover, a possible relationship has been suggested between altered auditory intensity processing and the hypophonic speech characteristics in PD. Nonetheless, further insight into the neurophysiological correlates of auditory intensity processing in patients with PD is needed primarily.In the present study, high-density EEG recordings were used to investigate intensity dependence of auditory evoked potentials (IDAEPs) in 14 patients with PD and 14 age-and gendermatched healthy control participants (HCs). Patients with PD were evaluated in both the on-and offmedication states. HCs were also evaluated twice.Significantly increased IDAEP of the N1/P2 was demonstrated in patients with PD evaluated in the on-medication state compared to HCs. Distinctive results were found for the N1 and P2 component. Regarding the N1 component, no differences in latency or amplitude were shown between patients with PD and HCs regardless of the medication state. In contrast, increased P2 amplitude was demonstrated in patients with PD evaluated in the on-medication state compared to the off-medication state and HCs.In addition to a dopaminergic deficiency, deficits in serotonergic neurotransmission in PD were shown based on increased IDAEP. Due to specific alterations of the N1-P2 complex, the current results suggest deficiencies in early-attentive inhibitory processing of auditory input in PD. This interpretation is consistent with the involvement of the basal ganglia and the role of dopaminergic and serotonergic neurotransmission in auditory gating.

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Central auditory processing in parkinsonian disorders: A systematic review

Cited by 13 publications

References 147 publications

Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

Effectiveness of the Auditory Temporal Ordering and Resolution Tests to Detect Central Auditory Processing Disorder in Adults With Evidence of Brain Pathology: A Systematic Review and Meta-Analysis

Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

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