Central catheter-associated deep vein thrombosis in cancer: clinical course, prophylaxis, treatment

Abstract

The adequate handling of central venous catheters is a key element in the management of patients with cancer. Catheter-associated deep vein thrombosis is frequently observed in patients with malignant diseases; however, despite being a common complication among these patients, objective information concerning its epidemiology, clinical course, prophylaxis and treatment strategies is very limited. The reported incidence of catheter-related thrombosis (CRT) is highly variable, depending on symptomatic events, or if patients are screened for asymptomatic thrombosis. Several factors have been identified as potential predisposing factors for CRT, both technical and pathological aspects. The anticoagulant of choice is still unclear; while low-molecular-weight heparin is most commonly used, recent studies assessing the role of direct oral anticoagulants in the treatment of CRT show promise as an alternative, but the evidence remains insufficient and the decision must be made on a case-by-case basis.

Analysis of the Preventive Action of Rivaroxaban against Lower Extremity Deep Venous Thrombosis in Patients after Laparoscopic Radical Gastrectomy

“…Also, Becattini et al [32] pointed out that Riv reduced the adverse events of patients after laparoscopic cancer surgery by 60% compared with placebo, which was [33]. To make matters worse, cancer patients will have a poor prognosis and similar symptoms after thrombosis in either deep or superficial veins [34]. As a common complication after various operations, the formation of venous thromboembolism will have a certain impact on the postoperative QoL of patients [35].…”

Observation on the effect of Intraoperative risk Management merged with comfort Nursing in Gynecological Laparoscopic surgery

“…( 2) The general anesthetics applied before the operation make the muscle pump function of the lower limbs disappear, the blood vessels are in a diastolic state, and the blood of the lower limbs becomes slow. (3) After operation, the external blood coagulation system in the body is activated, making the blood is in hypercoagulable contain [11][12][13][14][15][16].…”

Prévention et prise en charge des thromboses associées au cancer: questions pratiques à propos de l’anticoagulation

“…Enfin, les cathéters utilisés pour l'administration de la chimiothérapie augmentent le risque de maladie thromboembolique veineuse [12], une situation à prendre particulièrement en compte en cas d'hormonothérapie de type tamoxifène et justifiant une décision concertée au cas par cas. La survenue de thrombose induite par un cathéter est multifactorielle et peut résulter de l'agression de la paroi veineuse, d'une prédisposition (antécédent de thrombose veineuse profonde, facteur V Leiden) ou d'un problème technique [40]. Faute de scores complémentaires intégrant l'ensemble des traitements disponibles potentiellement thrombogènes, il paraît cohérent de considérer le score COMPASS-CAT pour les patientes sous hormonothérapie comme base de discussions en RCP tel que cela est proposé dans les référentiels de l'AFSOS [18].…”