Central Corneal Thickness After Cross-linking Using High-Definition Optical Coherence Tomography, Ultrasound, and Dual Scheimpflug Tomography: A Comparative Study Over One Year

Antonios, Rafic; Fattah, Maamoun Abdul; Maalouf, Fadi; Abiad, Bachir; Awwad, Shady T.

doi:10.1016/j.ajo.2016.04.004

Cited by 31 publications

(20 citation statements)

References 25 publications

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“…In conventional CXL, the edema was described as being clinically high for up to 7 days in an experimental rabbit model 28 and high up to 2 weeks using high-definition optical coherence tomography, ultrasound and dual Scheinmplug tomography in humans due to transient mild endothelial decompensation. 30,31 However, 2 months later, corneas had no edema at slit-lamp in a rabbit eye study. 26 Corneal thickness measured on H-E sections also showed continued thickening in DE corneas for up to 2 months, while RGX led to cornea slimming (Fig.…”

Section: Discussionmentioning

confidence: 98%

“…The anterior segment of the eyes was evaluated with a surgical microscope (Leica M220 F12; Leica Microsystems, Nussloch, Germany) before and after treatments and at different time points (1,2,3,4,15,30, and 60 days, immediately prior to euthanasia). In the clinical follow-up, the epithelial wound was stained by sodium fluorescein (Fluotest; Alcon, Cusi, Barcelona) every day until epithelial closure.…”

Section: Clinical Coursementioning

confidence: 99%

See 1 more Smart Citation

Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study

Gallego‐Muñoz

Ibares‐Frías

Lorenzo

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 98%

Section: Clinical Coursementioning

confidence: 99%

Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study

Gallego‐Muñoz

Ibares‐Frías

Lorenzo

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…Antonios et al 29 reported that OCT might better estimate the true CCT following CXL as compared with Scheimpflug tomography. With the use of OCT, we found that at 3 years postoperatively as compared with baseline, all sectors of pachymetry thickness as well as epithelial thickness showed no significant differences, except for the paracentral superior sector, which showed significantly increased thickness.…”

Section: Discussionmentioning

confidence: 99%

Three-year follow-up of accelerated transepithelial corneal cross-linking for progressive paediatric keratoconus

et al. 2020

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PurposeTo investigate the long-term safety and efficacy of accelerated transepithelial corneal cross-linking (ATE-CXL) in children with progressive keratoconus.MethodsFifty-three eyes of 41 paediatric patients (34 boys, 7 girls; mean age 14.81±1.96 years) undergoing ATE-CXL were enrolled in the study. Corrected distance visual acuity (CDVA) and manifest refraction were assessed preoperatively and 36 months postoperatively. Corneal keratometry, corneal thickness and posterior elevation were measured using Pentacam preoperatively and 1, 6, 12 and 36 months postoperatively. Pachymetry and epithelial thicknesses were measured using optical coherence tomography preoperatively and 6, 12, and 36 months postoperatively.ResultsThirty-six months postoperatively, CDVA improved from 0.32±0.28 to 0.26±0.25 in logarithm of the minimum angle resolution (p=0.025). Maximum keratometry was 58.73±9.70 D preoperatively and 59.20±10.24, 58.28±9.33, 57.88±9.99 and 58.98±10.79 D at 1, 6, 12 and 36 months postoperatively throughout the 36-month follow-up period (p>0.05). Similarly, corneal central thickness, which was 492.42±33.83 µm postoperatively, also remained stable during the 36-month follow-up (p>0.05). Both posterior central elevation and posterior highest elevation were stable at 12 months after ATE-CXL (p>0.05), but increased at 36 months postprocedure (p<0.05). Corneal pachymetry and epithelial thicknesses remained stable throughout the follow-up period (p>0.05).ConclusionsATE-CXL is a safe and effective treatment in paediatric progressive keratoconus patients, leading to stable keratometry and corneal thickness throughout the 36-month follow-up.

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“…The reduction in corneal thickness between 1 and 3 months may be a result of progressive re-epithelization and compaction of stromal lamellae after crosslinking. There is also evidence that pachymetry with Scheimpflug imaging system may underestimate corneal thickness in the early postoperative period due to stromal haze and changes in reflectivity [24]. …”

Section: Discussionmentioning

confidence: 99%

Conventional Versus Accelerated Collagen Cross-Linking for Keratoconus: A Comparison of Visual, Refractive, Topographic and Biomechanical Outcomes

Woo¹,

Iyer²,

Lim

et al. 2017

TOOPHTJ

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Objective:The aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated with either conventional or accelerated crosslinking at one year follow up.Methods:It is a prospective, non-randomised interventional study of 76 patients who underwent conventional (CXL; 3mW/cm2 for 30 minutes) or accelerated cross linking (KXL; 30mW/cm2 for 4 minutes) for progressive keratoconus. Baseline and postoperative visual acuity, manifest refraction, corneal topography, pachymetry, endothelial cell density and biomechanical parameters of corneal hysteresis and corneal resistance factor were evaluated and compared.Results:The 2 groups were comparable in terms of uncorrected and best corrected visual acuity and spherical equivalent. Both groups showed no significant increase in K1, K2 and Kmean from baseline at 12 months. There was also no difference between the CXL and KXL group for postoperative corneal topography as well as central and minimal pachymetry up to 12 months. There was a significant increase in both corneal hysteresis (0.62mm Hg, P=0.04) and corneal resistance factor (0.91mm Hg, P=0.003) in the KXL group at 12 months but not in the CXL group. There was no significant endothelial cell loss throughout follow up in both the groups.Conclusion:We have established comparability of the 2 protocols in stabilizing the progression of keratoconus. Our findings also suggested an added biomechanical advantage of accelerated crosslinking at 1 year follow up.

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Central Corneal Thickness After Cross-linking Using High-Definition Optical Coherence Tomography, Ultrasound, and Dual Scheimpflug Tomography: A Comparative Study Over One Year

Cited by 31 publications

References 25 publications

Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study

Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study

Three-year follow-up of accelerated transepithelial corneal cross-linking for progressive paediatric keratoconus

Conventional Versus Accelerated Collagen Cross-Linking for Keratoconus: A Comparison of Visual, Refractive, Topographic and Biomechanical Outcomes

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