Central corneal thickness in the ocular hypertension treatment study (OHTS)

Brandt, James D.; Beiser, Julia A.; Kass, Michael A.; Gordon, Mae O.

doi:10.1016/s0161-6420(01)00760-6

Cited by 558 publications

(310 citation statements)

References 21 publications

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“…This may explain the findings that mean CCT is thinner in patients with normal tension glaucoma compared with those having POAG, 6,7 and thicker in patients with OHT. 8,9 These findings are replicated among different racial groups. 10 In addition, in a multivariate analysis of baseline factors predicting the conversion of OHT into POAG within OHTS, CCT was retained as a risk factor independent of its relationship with IOP.…”

Section: Introductionmentioning

confidence: 66%

“…In addition to our study, other researchers have found a significant thinning of the central cornea with age. 8,10,19,20 Two studies which also only recruited older participants, failed to detect a significant relationship. [21][22][23][24] The changes in structural corneal biomechanics with subject age adds further complexity to the relationship between CCT and Goldmann IOP.…”

Section: Discussionmentioning

confidence: 97%

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The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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Purpose To determine population-based normative CCT data for elderly white subjects, with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields. Methods All eligible subjects were consecutive in a population screened for eye disease. CCT was measured by ultrasound pachymetry, and the optic disc was morphometrically defined using Heidelberg retinal tomography (HRT2). Inclusion criteria were: (1) normal visual field on suprathreshold testing and (2) corrected logMAR acuity of at least 0.3 in both eyes. Subjects with significant corneal pathology, previous corneal surgery, or known history of glaucoma or treatment for raised intraocular pressure were excluded. One eye was randomly selected from each subject for analysis. Results In all, 983 eyes of 983 subjects were included with 690 HRT images deemed acceptable for the analysis. The mean age (414 men and 569 women) was 73.3 years (minimum 65 years). Mean (SD) CCT was 544.1 (36.5) lm, with a normally distributed range of 429-633 lm. There was no significant difference in CCT between men and women (mean CCT 546.1 and 542.7 lm, respectively, P ¼ 0.15, Student's t-test), though CCT was correlated weakly and negatively with age (Pearson's r ¼ À0.063, P ¼ 0.047). Diabetic patients (n ¼ 103) had a greater mean CCT than non-diabetic patients (551.9 and 543.0 lm respectively, P ¼ 0.02). No significant correlation was found between any global optic disc parameter and CCT in the 690 eyes analysed. Conclusion Elderly white eyes with normal fields have CCTs that are normally distributed, with those from diabetic persons having greater CCTs. No clear evidence of a relationship between CCT and HRT2 optic disc parameters used in glaucoma diagnosis was found.

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Section: Introductionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 97%

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

View full text Add to dashboard Cite

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“…Several studies have shown that 30-60% of ocular hypertension (OH) and normal tension glaucoma (NTG) patients are misclassified and possibly improperly treated due to a corneal thickness that is significantly deviated from the norm. [1][2][3][4] Goldmann applanation tonometry, in which the tonometer is calibrated based on a central corneal thickness (CCT) of 500 mm, has been the gold standard for IOP measurement for decades. 5 Studies comparing measurements with manometry and tonometry indicate that measuring CCT is essential to properly interpret the results obtained with a Goldmann applanation tonometer (GAT).…”

Section: Introductionmentioning

confidence: 99%

Varying Effects of Corneal Thickness on Intraocular Pressure Measurements with Different Tonometers

Liu

Hsu

2004

Eye

111

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Aims To compare the intraocular pressure (IOP) measurements using the Goldmann applanation tonometer (GAT), noncontact tonometer (NCT), and ocular blood flow tonometer (OBFT), and to evaluate the effects of varying central corneal thickness (CCT) on the readings. Methods Ultrasound pachymetry and tonometry were performed on 170 eyes. Using the corrected GAT values that took CCT into account as the standard, we calculated the NCT and OBFT measurement errors related to the CCT variable by a linear regression model. Group comparisons were performed with the v 2 test and one-way ANOVA test. The correlation between the various tonometer measurements was analysed by Pearson's correlation method. Results Both the NCT (r ¼ 0.872, Po0.001) and OBFT measurements (r ¼ 0.861, Po0.001) were highly correlated with the GAT measurements. IOP measurements using the three tonometers were all correlated with CCT (all Po0.001), with the NCT measurements showing the greatest regression coefficient (b ¼ 0.063, r ¼ 0.650) and the GAT measurements the least (b ¼ 0.037, r ¼ 0.496). A linear regression model indicated that a 10 lm change in CCT resulted in a NCT measurement deviation of 0.47-0.98 mmHg and an OBFT measurement deviation of 0.29-0.81 mmHg.Conclusion Pressure readings with the GAT, NCT, and OBFT are all affected by CCT, with the NCT being the one most affected and the GAT the least. Our findings suggest CCT an essential variable to consider in interpreting IOP readings, especially for the NCT measurements.

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“…For this reason, we selected our sample among casualty attenders only. It could be argued that differences exist between the population attending ophthalmic emergency departments and outpatients services (age range, corneal thickness, 21 anxiety in first time attenders 22 ) and that those differences could influence tonometric readings. Another element that we introduced in our study was a single observer in this case a NP.…”

Section: Discussionmentioning

confidence: 99%

A comparison of clinical performance between disposable and Goldmann tonometers

Maino

Uddin

Tullo

2005

Eye

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Purpose Applanation tonometry as performed in routine clinical practice is a significant potential vehicle for cross-infection particularly in an emergency eye care setting. The aim of this study is to evaluate the accuracy and reliability of three single-use devices (Tonoshield, Tonosafe, Tonojet) as an alternative to standard Goldmann prisms in an emergency eye department.Methods All patients attending the eye casualty at the Manchester Royal Eye Hospital for a period of 4 months who required intraocular pressure measurement were eligible for this prospective study. Exclusion criteria were: age below 18 years, corneal anomalies that might affect measurement, and refusal to participate. After taking informed consent, the patient was examined by one experienced nurse practitioner, who measured the intraocular pressure three times. In the first part of the study, we compared the standard Goldmann prism vs Tonoshield and Tonosafe prisms, while for the second part of the study we used standard Goldmann, Tonosafe, and Tonojet prisms. Agreement and repeatability tests were carried out on separate samples. Results Tonosafe and Tonojet correlated well with standard Goldmann tonometry (Po0.001), while the measurements obtained with Tonoshield were higher, especially for raised intraocular pressure measurements. Tonojet and Tonosafe measurements were more reproducible than Tonoshield measurements.Conclusions This study shows that Tonosafe and Tonojet are accurate and reliable alternatives to standard Goldmann tonometry.

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Central corneal thickness in the ocular hypertension treatment study (OHTS)

Cited by 558 publications

References 21 publications

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Varying Effects of Corneal Thickness on Intraocular Pressure Measurements with Different Tonometers

A comparison of clinical performance between disposable and Goldmann tonometers

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