Central line-associated bacteremia caused by drug-resistant Staphylococcus caprae after chemotherapy for acute myelogenous leukemia

First report of a <i>Staphylococcus caprae</i> isolated from middle ear fluid of an infant with recurrent acute otitis media

“…The susceptibility pattern of the isolate in the current case turned out to be similar to those reported by Vandenesch et al [14], Roland et al [9] and Kini et al [4]. However, meticillin-resistant S. caprae strains have also been reported [7,15]. The isolate in the current case proved to produce acid from mannitol, similar to 100%, 87% and over 90% of the human strains of S. caprae reported by Vandenesh et al [14], Shuttleworth et al [8] and Kawamura et al [3], respectively.…”

“…Since the time of its first isolation, only infrequent cases of human infections caused by S. caprae have been reported, among them endocarditis, sepsis, urinary tract infections, bone and joint infections [2][3][4][5]. Recently, meningitis following the infection of an intraspinal device and central lineassociated bacteraemia have been described [6,7]. One case of mastoiditis and cases of acute otitis externa have also been documented [8,9].…”

Staphylococcus caprae bone and joint infections: a re-emerging infection?

“…Among 386 S. caprae isolates reported in the literature, 17 of 22 were well identified by API Staph [7,9,13,15,18,20,23,40], [8,10,14,[18][19][20]23,38,41], 64 of 85 were well identified by Vitek [3,16,29,30,39,41], none of 15 were well identified by Microscan [3,29], nine were well identified by Phoenik [30], five of eight were well identified by 16S PCR (plus two false positives) [6,13,27,41], seven were well identified by soda gene sequencing [6,22], four were well-identified by tuf gene sequencing [6,41], 65 of 74 were well identified by ribotyping 16S-23S printer [4,8,23,40], 17 of 19 were well identified by internal transcribed spacer PCR [12,42], 17 of 19 were well identified by multiplex-PCR [32], four of five were well identified by pulsed-field gel electrophoresis [15], one was well identified by rpoB gene sequencing [31], one was well identified by autolysin gene sequencing [43], and 88 of 89 were w...…”

“…S. caprae also colonized the nares of ten infants hospitalized in the same unit, and the hand of a care provider in that unit [4]. Many other hospital-acquired S. caprae infections have been reported, including bacteraemia in a 2-day-old neonate [13], central line-associated bacteraemia in a patient after chemotherapy for acute myelogenous leukaemia [14], three cases of peritonitis after continuous ambulatory peritoneal dialysis [6], and a case of meningitis following intraspinal device infection [10].…”

“…Furthermore, S. caprae strains cause community-acquired and/or hospital-acquired infections in humans (Table 1), e.g. acute otitis externa [3,5], peritonitis [6], urinary tract infections [7,8], pneumonia [9], endocarditis [8], meningitis [10], and many cases of bacteraemia [4,8,9,[11][12][13][14][15][16]. Some S. caprae strains isolated from goats produce toxic shock syndrome toxin 1 [17].…”