2020
DOI: 10.1016/j.immuni.2020.09.005
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Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

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Cited by 136 publications
(148 citation statements)
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“…Moreover, clonotypes from both subsets can be recalled into secondary responses, indicating that each subset contributes to the long-lived memory compartment. The T-bet lo cells, which are CD71 neg CXCR5 + CCR7 + CD62L + , are phenotypically similar to the previously described RM B cell compartment (Andrews et al, 2019; Ellebedy et al, 2016) and transcriptional profiling of these cells revealed that they express higher levels of TCF7 and BACH2 - TFs that are associated with increased proliferation potential and stem-like qualities (Pais Ferreira et al, 2020; Tsukumo et al, 2013; Yao et al, 2021; Zhou et al, 2010). Thus, the T-bet lo memory population appears to be enriched for resting stem-like memory cells.…”
Section: Discussionsupporting
confidence: 71%
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“…Moreover, clonotypes from both subsets can be recalled into secondary responses, indicating that each subset contributes to the long-lived memory compartment. The T-bet lo cells, which are CD71 neg CXCR5 + CCR7 + CD62L + , are phenotypically similar to the previously described RM B cell compartment (Andrews et al, 2019; Ellebedy et al, 2016) and transcriptional profiling of these cells revealed that they express higher levels of TCF7 and BACH2 - TFs that are associated with increased proliferation potential and stem-like qualities (Pais Ferreira et al, 2020; Tsukumo et al, 2013; Yao et al, 2021; Zhou et al, 2010). Thus, the T-bet lo memory population appears to be enriched for resting stem-like memory cells.…”
Section: Discussionsupporting
confidence: 71%
“…3C). By contrast, TFs associated with stem-like or central memory cells (Pais Ferreira et al, 2020; Zhou and Xue, 2012), like TCF7 and LEF1, were predicted as regulators of the T-bet lo memory gene network (Fig. 3C).…”
Section: Resultsmentioning
confidence: 96%
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“…20,23 In addition, memory cells with stem cell-like qualities (T STEM ) also localize in lymphoid organs, exhibit overlapping features with T CM cells and some exhibit features of T cells that interact with B cell follicles. [24][25][26][27][28][29] In contrast, T RM cells enter, mature, and establish residence in multiple non-lymphoid tissues, wherein they remain largely positioned without re-circulating. 13,30 There is additional heterogeneity among T RM cells that is partly related to the tissue in which they reside, and their persistence at different times after infection within the same tissues, implying tissue and temporal-dependent regulation.…”
Section: The D Iver S It Y Of Anti G En -E Xperien Ced Cd8 T Cell Smentioning
confidence: 99%