Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining

Valeš, Karel; Stuchlı́k, Aleš

doi:10.1016/j.bbr.2005.02.012

Cited by 28 publications

(12 citation statements)

References 26 publications

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“…Active place avoidance [( 106 – 117 ), for review see Ref. ( 110 , 111 )] is a behavioral test specifically focusing on a rat’s ability to coordinate two conflicting frames of reference.…”

Section: Antimuscarinic Agents In Spatial Tasksmentioning

confidence: 99%

Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation

2017

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Muscarinic acetylcholine receptors (mAChRs) have been found to regulate many diverse functions, ranging from motivation and feeding to spatial navigation, an important and widely studied type of cognitive behavior. Systemic administration of non-selective antagonists of mAChRs, such as scopolamine or atropine, have been found to have adverse effects on a vast majority of place navigation tasks. However, many of these results may be potentially confounded by disruptions of functions other than spatial learning and memory. Although studies with selective antimuscarinics point to mutually opposite effects of M1 and M2 receptors, their particular contribution to spatial cognition is still poorly understood, partly due to a lack of truly selective agents. Furthermore, constitutive knock-outs do not always support results from selective antagonists. For modeling impaired spatial cognition, the scopolamine-induced amnesia model still maintains some limited validity, but there is an apparent need for more targeted approaches such as local intracerebral administration of antagonists, as well as novel techniques such as optogenetics focused on cholinergic neurons and chemogenetics aimed at cells expressing metabotropic mAChRs.

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Section: Antimuscarinic Agents In Spatial Tasksmentioning

confidence: 99%

Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation

2017

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“…Donepezil, an AChE inhibitor and most widely used treatment for Alzheimer's disease, donepezil at a dose of 5 ㎎/㎏ (oral administraion) was used as a positive control (Soma et al, 2013). Scopolamine interferes with memory and cognitive function and subsequently causes similar degrees of impairment test (Vales et al, 2005). The latency to enter the dark compartment during testing was significantly shorter in the scopolamine treated group (120.9 ± 5.2 sec) compared to that of the control group (265.9 ± 10.2 sec, p < 0.001).…”

Section: Protective Effect Of Safflower Extractsmentioning

confidence: 99%

Neuroprotective Effects of the Extracts from the Aerial Parts of Carthamus tinctorius L. on Transient Cerebral Global Ischemia in Rats

Kim¹,

Lee²,

Yang³

et al. 2014

Korean Journal of Medicinal Crop Science

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: In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of central nervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower could influence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day (200 ㎎/㎏ body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreased the induction/reduction -induced production of neuronal cell loss from global cerebral ischemia. Safflower markedly decreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances (TBARS) (55.2 ± 9.4 µmol mg -1) and significant improvement of activities of glutathione (GSH) (27.2 ± 5.0 µmol mg -1 ) in hippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell loss induced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment of vascular dementia.

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“…It is recommended to pursue a pre-exposure (habituation) to the environment. Some form of pre-training prior to manipulations should be also considered (Stuchlik and Vales, 2005;Vales and Stuchlik, 2005). Performance in the Carousel maze was demonstrated to be overtly impaired also by NMDA-induced lesion of the dorsal hippocampus as a model of excitotoxic damage to the brain (Rambousek et al, 2011), such as in the case of ischemia or stroke.…”

Section: Properties Of the Place Avoidance And Carousel Mazementioning

confidence: 99%

“…4. In particular, the Carousel maze has proved to be a suitable test of altered behavior in animal models of brain disorders, mainly schizophrenia (a pharmacological model induced by systemic treatment with a psychotomimetic MK-801, a non-competitive NMDA receptor antagonist) and has been used in several animal model studies todate (Stuchlik et al, 2004;Stuchlik and Vales, 2005;Vales et al, 2006, Bubenikova-Valesova et al, 2008, Stuchlik et al, 2009. Notably, the task was not found to be sensitive to an electrolytic lesion of the posterior parietal cortex (Svoboda et al, 2008), but is dependent on an intact retrosplenial cortex (RSC; Wesierska et al, 2009).…”

Section: Development Of Place Avoidance Tasks and Carousel Mazementioning

confidence: 99%

“…The Carousel maze (previously also termed active allothetic place avoidance (AAPA) or active place avoidance task (Stuchlik et al, 2004;Stuchlik and Vales, 2005;Vales et al, 2006, Stuchlik et al, 20092008) or Room+/Arena-task (Weiserska et al, 2005;Kubik and Fenton 2005) is a variant of the place avoidance task Fenton et al, 1998, Cimadevilla et al, 2000a2001a,b,c), in which a rodent (typically a rat, but the maze can be used with mice as well; Cimadevilla et al, 2001a) is placed on a smooth circular arena and required to avoid a directly imperceptible to-beavoided sector. In the Carousel maze, the experimental arena slowly continuously rotates (1 rpm) in a lighted room and the to-be-avoided sector (60 deg) is defined in the fixed position in the coordinate frame of the room.…”

Section: The Carousel Mazementioning

confidence: 99%

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Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders

Stuchlı́k¹,

Petrásek²,

Hatalova³

et al. 2012

Schizophrenia in the 21st Century

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Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining

Cited by 28 publications

References 26 publications

Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation

Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation

Neuroprotective Effects of the Extracts from the Aerial Parts of Carthamus tinctorius L. on Transient Cerebral Global Ischemia in Rats

Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders

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