Central nervous system-active drug abused and overdose in children: a worldwide exploratory study using the WHO pharmacovigilance database

Carnovale, Carla; Mahzar, Faizan; Scibelli, Sara; Gentili, Marta; Arzenton, Elena; Moretti, Ugo; Leoni, Olivia; Pozzi, Marco; Peeters, Gabriëlla G. A. M.; Clementi, Emilio; Medaglia, Massimo; Radice, Sonia

doi:10.1007/s00431-018-3281-0

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…Many studies have been carried out on psychotropic drugs, including antipsychotics, based on data extracted from the VigiBase 11,12 . Moreover, early signals of drug abuse have already been highlighted using data from the VigiBase database 13 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 Moreover, early signals of drug abuse have already been highlighted using data from the VigiBase database. 13 The objective of this study was to analyse the worldwide data collected in the VigiBase database to identify potential abuse/misuse signals concerning SGAPs. The second objective was to discuss the results relative to the pharmacological profile of these molecules.…”

Section: Introductionmentioning

confidence: 99%

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Abuse and misuse of second‐generation antipsychotics: An analysis using VigiBase, the World Health Organisation pharmacovigilance database

Roy

Charreteur

Peries

et al. 2022

Brit J Clinical Pharma

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The study aim was to assess the abuse/misuse potential of second‐generation antipsychotics (SGAPs) using VigiBase data. We extracted individual case safety reports of “Drug abuse, dependence and withdrawal” involving SGAPs up to June 2018. We assessed disproportionate reporting by calculating the information component, considering the lower end of the 95% credibility interval for the information component (IC025), and the proportional reporting ratio. We identified 1683 individual case safety reports recorded as “abuse, dependence and withdrawal” involving SGAPs, mainly quetiapine (n = 1089) and olanzapine (n = 209). The disproportional reporting indicators highlighted an association between “Drug abuse and dependence”, and quetiapine, olanzapine and ziprasidone, as indicated by the IC025 (2.263, 0.259 and 1.051, respectively) and proportional reporting ratio values (3.929, 1.020 and 1.334, respectively). The abuse/misuse potential is confirmed for quetiapine and olanzapine and highlighted for the first time for ziprasidone. Physicians should consider these risks when prescribing these antipsychotics, especially to patients with history of drug abuse.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abuse and misuse of second‐generation antipsychotics: An analysis using VigiBase, the World Health Organisation pharmacovigilance database

Roy

Charreteur

Peries

et al. 2022

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…42 The effects of most toxic agents can be controlled once the infant is hospitalised, but the child may still suffer from long-term health implications, particularly if the agent affects the liver, kidneys, or central nervous system. 43,44 Lockable or secure high-level cupboards reduce the risk of infants coming into contact with such agents. 45…”

Section: Introductionmentioning

confidence: 99%

Evidence base for a housing warrant of fitness

et al. 2019

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Substandard housing is a major public health issue in New Zealand. Approximately, two-thirds of the housing stock is uninsulated and many homes are inadequately heated, with an average indoor temperature of 14.5°C. Cold, damp, and mouldy housing results in poor health; each year, respiratory hospital admissions are 74% higher during winter, and excess winter mortality is 20% higher than other seasons. The relationship between injury and housing conditions is also well established. Each year, 500,000 New Zealanders suffer falls requiring medical treatment in their homes. As a step towards improving the quality of existing housing, an evidence-based warrant of fitness has been developed. This article outlines the evidence base to each criterion in the warrant of fitness. We conclude that introducing and properly enforcing a housing warrant of fitness will ensure that basic minimum standards are met, which could mitigate the disease burdens and injuries associated with, or caused, by poorer quality housing. In addition, there are potential fiscal and economic advantages of the scheme, including reduced hospitalisations and increased productivity.

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Central nervous system-active drug abused and overdose in children: a worldwide exploratory study using the WHO pharmacovigilance database

Cited by 2 publications

References 40 publications

Abuse and misuse of second‐generation antipsychotics: An analysis using VigiBase, the World Health Organisation pharmacovigilance database

Abuse and misuse of second‐generation antipsychotics: An analysis using VigiBase, the World Health Organisation pharmacovigilance database

Evidence base for a housing warrant of fitness

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