Central nervous system b-cell lymphoma in multiple sclerosis

Abstract

The differential diagnosis of multiple sclerosis is extensive and it can be challenging to diagnose initially in the absence of pathognomonic clinical features. Furthermore, these patients can also develop other diseases during their course of treatment, which usually lasts for many years. Some conditions, such as primary central nervous system lymphoma, can mimic clinically some of the symptoms prominent in multiple sclerosis. Early treatment with corticosteroids can also dramatically improve patient symptoms in both conditions. We report a case of a man diagnosed with histologically confirmed relapsing remitting multiple sclerosis who subsequently developed histologically confirmed primary central nervous system lymphoma. The course of his disease and treatment are presented and the current literature reviewed.

Discovering miRNAs Associated With Multiple Sclerosis Based on Network Representation Learning and Deep Learning Methods

“…The second-best enriched term is B-cell lymphoma. A previous study has reported that B-cell lymphoma has some similar symptoms with MS, and early treatment with corticosteroids can improve patient symptoms in both conditions ( Lyons et al, 2012 ). We can also find more genetic or clinical links between Multiple Sclerosis and acquired immunodeficiency syndrome ( Morriss et al, 1992 ), chronic kidney disease ( Ruiz-Argüelles et al, 2019 ), papillary thyroid carcinoma ( D’Amico et al, 2019 ), HIV Infections ( Gold et al, 2015 ), type 2 diabetes mellitus ( Hussein and Reddy, 2006 ), Parkinson’s disease ( Delalić et al, 2020 ), Uterine Cervical Neoplasm ( Doosti et al, 2018 ), and Hepatitis ( Cação et al, 2018 ).…”

Multifocal central nervous system lymphoma misdiagnosed as acute disseminated encephalomyelitis

“…Кроме того, описаны развитие лимфом головного мозга в результате трансформации лимфоматоидного гранулематоза, а также случаи развития лимфом у пациентов с гистологически подтвержденными (так называемыми «сторожевыми» очагами демиелинизации), появление которых предшествует возникновению лимфомы [19][20][21]. Описаны случаи сочетания РС и ПЛЦНС [22,23], а также развития лимфомы у пациентов с РС при терапии натализумабом [24].…”