Central nervous system development in rabbits (<scp><i>Oryctolagus cuniculus</i></scp> L. 1758)

Anunciação, Adriana Raquel de Almeida da; Favaron, Phelipe Oliveira; Morais‐Pinto, Luciano de; Carvalho, Carlos Augusto Brandão de; Martins, Daniele dos Santos; Conei, Daniel; Sol, Mariano del; Vásquez, Bélgica; Miglino, Maurizio

doi:10.1002/ar.24586

Cited by 5 publications

(1 citation statement)

References 71 publications

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“…Large animal models are well-suited for mimicking neurological disorders ( Zhou et al, 2015 ), but require substantial maintenance costs and present challenges in manipulation. Importantly, the development of the central nervous system in rabbits closely resembles that in humans, enabling cost-effective and accurate generation of neurological disease models that cannot be effectively recapitulated in mice ( De Almeida Da Anunciação et al, 2021 ). Tay-Sachs disease (TSD), characterized by progressive neurodegeneration, arises from autosomal recessive deficiency of β-hexosaminidase A (HeXA).…”

Section: Generation Of Genome-edited Rabbits In Biomedical Researchmentioning

confidence: 99%

Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases

Han,

Zhou,

Zhang

et al. 2024

Zoological Research

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Animal models are extensively used in all aspects of biomedical research, with substantial contributions to our understanding of diseases, the development of pharmaceuticals, and the exploration of gene functions. The field of genome modification in rabbits has progressed slowly. However, recent advancements, particularly in CRISPR/Cas9-related technologies, have catalyzed the successful development of various genome-edited rabbit models to mimic diverse diseases, including cardiovascular disorders, immunodeficiencies, aging-related ailments, neurological diseases, and ophthalmic pathologies. These models hold great promise in advancing biomedical research due to their closer physiological and biochemical resemblance to humans compared to mice. This review aims to summarize the novel gene-editing approaches currently available for rabbits and present the applications and prospects of such models in biomedicine, underscoring their impact and future potential in translational medicine.

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Section: Generation Of Genome-edited Rabbits In Biomedical Researchmentioning

confidence: 99%

Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases

Han,

Zhou,

Zhang

et al. 2024

Zoological Research

View full text Add to dashboard Cite

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Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives

Neziri,

Köseoğlu,

Deniz Köseoğlu

et al. 2024

Anim Models and Exp Med

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Animal models have been a crucial tool in neuroscience research for decades, providing insights into the biomedical and evolutionary mechanisms of the nervous system, disease, and behavior. However, their use has raised concerns on several ethical, clinical, and scientific considerations. The welfare of animals and the 3R principles (replacement, reduction, refinement) are the focus of the ethical concerns, targeting the importance of reducing the stress and suffering of these models. Several laws and guidelines are applied and developed to protect animal rights during experimenting. Concurrently, in the clinic and biomedical fields, discussions on the relevance of animal model findings on human organisms have increased. Latest data suggest that in a considerable amount of time the animal model results are not translatable in humans, costing time and money. Alternative methods, such as in vitro (cell culture, microscopy, organoids, and micro physiological systems) techniques and in silico (computational) modeling, have emerged as potential replacements for animal models, providing more accurate data in a minimized cost. By adopting alternative methods and promoting ethical considerations in research practices, we can achieve the 3R goals while upholding our responsibility to both humans and other animals. Our goal is to present a thorough review of animal models used in neuroscience from the biomedical, evolutionary, and ethical perspectives. The novelty of this research lies in integrating diverse points of views to provide an understanding of the advantages and disadvantages of animal models in neuroscience and in discussing potential alternative methods.

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YIPF5 (p.W218R) mutation induced primary microcephaly in rabbits

Liu

Yang

et al. 2023

Neurobiology of Disease

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Central nervous system development in rabbits (Oryctolagus cuniculus L. 1758)

Cited by 5 publications

References 71 publications

Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases

Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases

Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives

YIPF5 (p.W218R) mutation induced primary microcephaly in rabbits

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