Central nervous system involvement in early and late syphilis: The problem of asymptomatic neurosyphilis

Wolters, Erik Ch.; Hische, E A; Tutuarima, J.A.; Trotsenburg, L van; Eijk, Ron V.W. van; Bos, Jan D.; Starink, Th. M.; Emsbroek, Lex J.; Helm, H J van der

doi:10.1016/0022-510x(88)90220-1

Cited by 28 publications

(18 citation statements)

References 18 publications

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“…biological false positive -BFP) wyniki odczynów niekrętkowych występu-ją w różnych stanach, ich częstość ocenia się na 0,2-0,8% wszystkich odczynów (według niektó-rych badań występują nawet częściej badania laboratoryjne w celu potwierdzenia lub wykluczenia kiły ośrodkowego układu nerwowego [49][50][51][52][53][54][55][56][57][58][59] U każdego pacjenta z dodatnimi odczynami kiło-wymi należy przeprowadzić pełne badanie neurologiczne, okulistyczne i laryngologiczne. Uważa się jednak, że u chorych bez objawów klinicznych badania takie rzadko są przydatne [60].…”

Section: Diagnostyka Laboratoryjnaunclassified

2014 European guideline on the management of syphilis

Janier¹,

Hegyi²,

Dupin³

et al. 2015

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Section: Diagnostyka Laboratoryjnaunclassified

2014 European guideline on the management of syphilis

Janier¹,

Hegyi²,

Dupin³

et al. 2015

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“…Classical abnormalities are a reactive CSF-VDRL test, pleocytosis and elevated CSF protein levels. However, normal values of these three parameters have been found in neurosyphilis 11,17,19,20,22) . The CSF WBC count is generally abnormal in early meningovascular neurosyphilis, but it is not necessarily abnormal in late parenchymatous neurosyphilis 21) .…”

Section: Discussionmentioning

confidence: 99%

“…CSF glucose is normal but occasionally it may be slightly decreased, especially in HIV coinfected patients 15) . CSF VDRL, despite its high specificity, has limited application due to its low sensitivity, especially in asymptomatic neurosyphilis 11,17,19,22) . False-positive CSF VDRL results can occur occasionally 11) , although rarely, due to blood contamination.…”

Section: Discussionmentioning

confidence: 99%

Experience of Meningovascular Syphilis in Human Immunodeficiency Virus Infected Patient

Lee

Koo

Jin

et al. 2009

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 46 : [413][414][415][416] 2009 Since the start of the antibiotic era, syphilis has become rare. However, in recent times, it has tended to be prevalent concomitantly with human immunodeficiency virus (HIV) infection and coinfection in North America and Europe. Now, such cases are expected to increase in elsewhere including Korea. A 40-year-old male patient visited hospital complaining of a headache for about one month. Brain computed tomography and magnetic resonance imaging, showed leptomeninged enhancing mass with edema an right porisylvian region, which was suspected to be glioma. Patient underwent a blood test and was diagnosed with syphilis and acquired immune deficiency syndrome. Partial cortical and subcortical resection were performed after small craniotomy. The dura was thick, adhered to the brain cortex, and was accompanied by hyperemic change of the cortex. The pathologic diagnosis was meningovascular syphilis (MS) in HIV infection. After the operation, the patient was treated with aqueous penicillin G.

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“…Classical abnormalities are a reactive CSF-VDRL test, pleocytosis and elevated CSF protein levels. However, normal values of these three parameters have been found in neurosyphilis [19,[33][34][35][36]. The CSF WBC count is generally abnormal in early meningovascular neurosyphilis, but it is not necessarily abnormal in late parenchymatous neurosyphilis [9].…”

Section: Discussionmentioning

confidence: 99%