Central retinal vein occlusion associated with platelet activation

Abstract

Purpose:The aim of this article is to determine and compare the platelet activation by three main platelet activation parameters: mean platelet volume, platelet distribution width, and plateletcrit in patients with central retinal vein occlusion and control subjects.Methods:This study included 30 patients with nonischemic central retinal vein occlusion and 30 control subjects. The levels of mean platelet volume, platelet distribution width, and plateletcrit were measured in all groups.Results:The mean serum level of mean platelet volume was 10.01 ± 0.89 fl in central retinal vein occlusion group and 8.74 ± 1.45 fl in control group. The mean serum level of platelet distribution width was 14.31 ± 1.49% and 11.65 ± 1.81% in central retinal vein occlusion group and control group, respectively. Mean serum plateletcrit value was 0.27 ± 0.07% in central retinal vein occlusion group and 0.23 ± 0.07% in control group. Mean platelet volume, platelet distribution width, and plateletcrit levels were significantly higher in central retinal vein occlusion patients than controls ( p < 0.05).Conclusion:Subclinical platelet activation reflected by mean platelet volume, platelet distribution width, and plateletcrit may have an impact on the genesis of vessel occlusion in central retinal vein occlusion. The results may be important for the clinical management of patients with central retinal vein occlusion.

Complete Blood Count-Derived Inflammation Indices and Retinal Vein Occlusion: A Case–Control Study

“…Mean platelet volume, a marker of platelet activation, has been investigated in patients with RVO, with a recent meta-analysis reporting that MPV is significantly elevated in patients with RVO compared to controls [ 7 ]. This is in line with the majority of studies [ 31 – 37 ], while Ornek et al observed lower MPV values in patients with RVO [ 38 ] and Turkseven Kumral et al observed unaffected indices [ 30 ].…”

Predictive value of plateletcrit in the diagnosis of lower extremity deep vein thrombosis

“…In a study by Akpinar et al [20] increased PCT values were found effective in the development of saphenous vein disease after coronary bypass operations. In another study, PCT values were found to be higher in patients with central retinal vein occlusion than in healthy individuals [6]. The relationship of recurrent pregnancy loss with thrombosis is known.…”

“…Plateletcrit (PCT) is a parameter obtained by multiplying MPV with platelet count. In a recent study, PCT value was reportedly higher in patients with retinal vein thrombosis compared to the control group [6].…”

The effect of select systemic medications on outcomes in diabetics with central retinal vein occlusion

“…11 , 12 In addition, metformin, sulfonylureas, thiazolidinediones, and sitagliptin have also been shown to reduce platelet hyperactivity associated with diabetes and CRVO. 13 , 14 In contrast, basal insulin and sulfonylureas appear to be neutral on cardiovascular disease outcomes. 15 , 16 Given the association between cardiovascular risk and CRVO, these studies raise the important question as to whether systemic medications commonly used by diabetics may affect clinical features and outcomes in CRVO.…”