2017
DOI: 10.1016/j.bbi.2017.07.010
|View full text |Cite
|
Sign up to set email alerts
|

Central serotonin attenuates LPS-induced systemic inflammation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
7
0
2

Year Published

2019
2019
2024
2024

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(10 citation statements)
references
References 85 publications
1
7
0
2
Order By: Relevance
“…Additionally, kynurenic acid, which is detoxified kynurenine, reduced the release of IL-4 through the specific activation of G protein-coupled receptor 35 (GPR35) [34], and quinolinic acid have a role in protect the body from inflammatory injury via a direct action on neutrophils or vascular permeability 20 [35]. Melatonin, serotonin and N-acetylserotonin also have ability to inhibit production of inflammatory cytokines and superoxide [36,37,38]. Meanwhile, increase in the production of glutamic acid (glutamate) and NADP have a favor role involved in the purine metabolism and glutathione metabolism while coenzyme A affect phenylacetate metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, kynurenic acid, which is detoxified kynurenine, reduced the release of IL-4 through the specific activation of G protein-coupled receptor 35 (GPR35) [34], and quinolinic acid have a role in protect the body from inflammatory injury via a direct action on neutrophils or vascular permeability 20 [35]. Melatonin, serotonin and N-acetylserotonin also have ability to inhibit production of inflammatory cytokines and superoxide [36,37,38]. Meanwhile, increase in the production of glutamic acid (glutamate) and NADP have a favor role involved in the purine metabolism and glutathione metabolism while coenzyme A affect phenylacetate metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…Martins [78] suggested that plasma LPS should be monitored in early life to prevent mitochondrial apoptosis in neurodegenerative diseases. Mota et al [79] investigated the relationship between central 5-HT and LPS-induced systemic inflammation in animals. In this study, the authors showed a marked decrease in both the Anteroventral Preoptic Region (AVPO) 5-HT and 5-HIAA 300 min after LPS administration and enhanced corticosterone concentrations 45 and 300 min after LPS administration.…”
Section: Gut Motilitymentioning
confidence: 99%
“…Serotonin (5‐hydroxytryptamine, 5‐HT) is an important neurotransmitter and hormone that modulates many physiological functions including cardiovascular, respiration, immune, energy balance and body temperature . Changes in the level of circulating 5‐HT have the potential to influence the CNS regulation of homeostatic functions either through alterations in afferent signalling or through direct effects on CNS 5‐HT receptors (5‐HTR), although whether 5‐HT crosses the blood‐brain barrier remains controversial .…”
Section: Introductionmentioning
confidence: 99%