Centrally Acting Isosteric Mannich Bases

Orth, Ronald; Bennett, Jacqueline; Ma, On-Hou; Young, Larry J.

doi:10.1002/jps.2600571048

Journal of Pharmaceutical Sciences

1968

DOI: 10.1002/jps.2600571048

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Centrally Acting Isosteric Mannich Bases

Ronald Orth

Jacqueline Bennett

On-Hou Ma

et al.

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Cited by 4 publications

References 7 publications

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Synthesis of 1‐(N‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones

Piao¹,

Wang²,

Lu³

et al. 1993

Journal of Heterocyclic Chem

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Reactions of 3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐one (2) with arylamines in the presence of formaldehyde gave 1‐(N‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones 5a‐l in good yields. 1,3,5‐Tris(phenyl‐ and 4‐methoxyphenyl)hexahydro‐1,3,5‐triazines or bis(3‐nitroanilino)methane, which were condensation products of arylamines and formaldehyde, also reacted with compound 2 to afford 5a,c,j, respectively.

show abstract

Synthesis of 1‐(N‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones

Piao¹,

Wang²,

Lu³

et al. 1993

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

Hydrolysis of N-Mannich bases and its consequences for the biological testing of such agents

Bundgaard¹,

Johansen²

1981

International Journal of Pharmaceutics

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Direct Imidazolylmethylation of Phenols

Jiang

Zhang

Yuan

et al. 1994

Synthetic Communications

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Centrally Acting Isosteric Mannich Bases

Cited by 4 publications

References 7 publications

Synthesis of 1‐(N‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones

Synthesis of 1‐(N‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones

Hydrolysis of N-Mannich bases and its consequences for the biological testing of such agents

Direct Imidazolylmethylation of Phenols

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