Centre credentialing for Trans Tasman Radiation Oncology Group trial 06.02: multicentre feasibility study of accelerated partial breast irradiation

Kron, Tomas; Willis, David J.; Bignell, Fiona; Martland, Judith; Donnell, Steve C.; May, S; Chua, BH

doi:10.1111/j.1754-9485.2009.02097.x

Cited by 8 publications

(16 citation statements)

References 12 publications

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“…This indicates that patients should not be excluded for PBI on the basis of PBI breast volume ratio. Patients may also still be eligible for PBI if the seroma is larger than 2 cm, which has been used as selection criteria in recent clinical trials 14,30,32 and < 3 cm as per international consensus statements and guidelines. 5,6,13 Our study reported a 21% incidence of UIQ targets for the imaging study and 26% for the positioning component, which is higher than the 16% reported elsewhere.…”

Section: Discussionmentioning

confidence: 99%

The effect of imaging modality (magnetic resonance imaging vs. computed tomography) and patient position (supine vs. prone) on target and organ at risk doses in partial breast irradiation

Brown

Dundas

Surjan

et al. 2020

J of Medical Radiation Sci

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Introduction: Conventionally computed tomography (CT) has been used to delineate target volumes in radiotherapy; however, magnetic resonance imaging (MRI) is being continually integrated into clinical practice; therefore, the investigation into targets derived from MRI is warranted. The purpose of this study was to evaluate the impact of imaging modality (MRI vs. CT) and patient positioning (supine vs. prone) on planning target volumes (PTVs) and organs at risk (OARs) for partial breast irradiation (PBI). Methods: A retrospective data set, of 35 patients, was accessed where each patient had undergone MRI and CT imaging for tangential whole breast radiotherapy in both the supine and prone position. PTVs were defined from seroma cavity (SC) volumes delineated on each respective image, resulting in 4 PTVs per patient. PBI plans were generated with 6MV external beam radiotherapy (EBRT) using the TROG 06.02 protocol guidelines. A prescription of 38.5Gy in 10 fractions was used for all cases. The impact analysis of imaging modality and patient positioning included dose to PTVs, and OARs based on agreed criteria. Statistical analysis was conducted though Mann-Whitey U, Fisher's exact and chi-squared testing (P < 0.005). Results: Twenty-four patients were eligible for imaging analysis. However, positioning analysis could only be investigated on 19 of these data sets. No statistically significant difference was found in OAR doses based on imaging modality. Supine patient position resulted in lower contralateral breast dose (0.10Gy AE 0.35 vs. 0.33Gy AE 0.78, p = 0.011). Prone positioning resulted in a lower dose to ipsilateral lung volumes (10.85Gy AE 11.37 vs. 3.41Gy AE 3.93, P = <0.001). Conclusions: PBI plans with PTVs derived from MRI exhibited no clinically significant

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Section: Discussionmentioning

confidence: 99%

The effect of imaging modality (magnetic resonance imaging vs. computed tomography) and patient position (supine vs. prone) on target and organ at risk doses in partial breast irradiation

Brown

Dundas

Surjan

et al. 2020

J of Medical Radiation Sci

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“…The following structures were contoured for each case by a single individual (AS) to reduce intra‐operator variability: 24 …”

Section: Methodsmentioning

confidence: 99%

“…The following structures were contoured for each case by a single individual (AS) to reduce intra-operator variability: 24 1 The clinical target volume (CTV) was the ipsilateral whole breast as determined clinically and included all glandular breast tissues evident on the planning CT scans. The CTV was defined superiorly at the inferior edge of the clavicular head, inferiorly at the inframammary fold, medially at the ipsilateral sternal edge and laterally to include all apparent breast tissues.…”

Section: Target Volumes and Organs At Riskmentioning

confidence: 99%

Does inverse-planned intensity-modulated radiation therapy have a role in the treatment of patients with left-sided breast cancer?

Stillie

Kron

Herschtal³

et al. 2011

Journal of Medical Imaging and Radiation Oncology

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“…These techniques which exceed convention may be introduced safely in the context of multicenter feasibility studies. [11–13]…”

Section: Introductionmentioning

confidence: 99%

Introduction of online adaptive radiotherapy for bladder cancer through a multicentre clinical trial (Trans-Tasman Radiation Oncology Group 10.01)

Pham

Ryan

Kron

et al. 2013

Journal of Medical Physics

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Online adaptive radiotherapy for bladder cancer is a novel radiotherapy technique that was found feasible in a pilot study at a single academic institution. In September 2010 this technique was opened as a multicenter study through the Trans-Tasman Radiation Oncology Group (TROG 10.01 bladder online adaptive radiotherapy treatment). Twelve centers across Australia and New-Zealand registered interest into the trial. A multidisciplinary team of radiation oncologists, radiation therapists and medical physicists represented the trial credentialing and technical support team. To provide timely activation and proper implementation of the adaptive technique the following key areas were addressed at each site: Staff education/training; Practical image guided radiotherapy assessment; provision of help desk and feedback. The trial credentialing process involved face-to-face training and technical problem solving via full day site visits. A dedicated “help-desk” team was developed to provide support for the clinical trial. 26% of the workload occurred at the credentialing period while the remaining 74% came post-center activation. The workload was made up of the following key areas; protocol clarification (36%), technical problems (46%) while staff training was less than 10%. Clinical trial credentialing is important to minimizing trial deviations. It should not only focus on site activation quality assurance but also provide ongoing education and technical support.

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Centre credentialing for Trans Tasman Radiation Oncology Group trial 06.02: multicentre feasibility study of accelerated partial breast irradiation

Abstract: Given the impact of contouring on dose distributions, quality assurance procedures in clinical trials of PBI need to take into account both the technical approaches and the contouring.

Cited by 8 publications

References 12 publications

The effect of imaging modality (magnetic resonance imaging vs. computed tomography) and patient position (supine vs. prone) on target and organ at risk doses in partial breast irradiation

The effect of imaging modality (magnetic resonance imaging vs. computed tomography) and patient position (supine vs. prone) on target and organ at risk doses in partial breast irradiation

Does inverse-planned intensity-modulated radiation therapy have a role in the treatment of patients with left-sided breast cancer?

Introduction of online adaptive radiotherapy for bladder cancer through a multicentre clinical trial (Trans-Tasman Radiation Oncology Group 10.01)

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