Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification

Lu, Duoduo; Han, Yuemei; Liu, Dong; Chen, Siqi; Qie, Jiqiao; Qu, Jia; Lin, Quankui

doi:10.1016/j.actbio.2021.11.018

Cited by 28 publications

(35 citation statements)

References 63 publications

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“…This irregular and dispersed hierarchical nanostructure contributed to the highly specific surface areas and enhanced diffuse reflection, thus generating photothermal conversion with high efficiency. As optical characteristics are critical for visual recovery after IOL implantation, [ 23 ] we examined the spatial resolution efficiency of R‐IOL and P‐IOL based on the 1951 version of the United States Air Force (USAF) resolution board standard (Figures 2c and S1b, Supporting Information). No significant differences were noted between R‐IOL and P‐IOL, demonstrating that NPG modification did not cause differences in the spatial resolution of the optical center area.…”

Section: Resultsmentioning

confidence: 99%

Nanoporous Gold Ring‐Integrated Photothermal Intraocular Lens for Active Prevention of Posterior Capsular Opacification

Liu

Chen

et al. 2022

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Posterior capsular opacification (PCO) is the leading complication after cataract surgery, and is mainly induced by the proliferation and migration of residual lens epithelial cells (LECs). Although numerous attempts have been made to reduce the incidence of PCO, this complication remains a critical challenge in postoperative visual recovery. This study aims to report a functionalized intraocular lens (R‐IOL) with a region‐confined photothermal effect for the active prevention of PCO after implantation. The outer rim of R‐IOL (non‐optical area) is decorated with a nanoporous gold (NPG) ring, which can effectively eliminate the LECs around R‐IOL, ultimately inhibiting the migration of LECs from the periphery to the visual axis center in the initial stage, and preventing the subsequent PCO. Furthermore, the mechanism of LECs elimination can be attributed to apoptosis induced by mild photothermal therapy. After in vivo implantation for 30 days, PCO is rarely observed in the R‐IOL group, whereas the considerably higher incidence of PCO (75%) is found in the pristine IOL (P‐IOL) group. The region‐confined photothermal effect based on NPG not only provides an active strategy to effectively prevent PCO, but also introduces new opportunities for the treatment of undesirable hyperplasia.

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Section: Resultsmentioning

confidence: 99%

Nanoporous Gold Ring‐Integrated Photothermal Intraocular Lens for Active Prevention of Posterior Capsular Opacification

Liu

Chen

et al. 2022

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“…PLGA can effectively protect drugs from degradation and unrestrained release. Solutions of PLGA and cyclosporine A (CsA) were used to modify the IOL surface by Lu et al (2022) . The spin coating method was applied to construct the centrifuging concentric circles drug-loaded coating on the IOL surface.…”

Section: Intraocular Lens Surface Modification Materialsmentioning

confidence: 99%

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Luo

Wang

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Advances in cataract surgery have increased the demand for intraocular lens (IOL) materials. At present, the progress of IOL materials mainly contains further improving biocompatibility, providing better visual quality and adjustable ability, reducing surgical incision, as well as dealing with complications such as posterior capsular opacification (PCO) and ophthalmitis. The purpose of this review is to describe the research progress of relevant IOL materials classified according to different clinical purposes. The innovation of IOL materials is often based on the common IOL materials on the market, such as silicon and acrylate. Special properties and functions are obtained by adding extra polymers or surface modification. Most of these studies have not yet been commercialized, which requires a large number of clinical trials. But they provide valuable thoughts for the optimization of the IOL function.

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“…For example, the CsA-loaded PLGA (CsA@PLGA) coating-modified IOL prepared by Teng et al [ 103 ] reduced the degree of PCO within six months after implantation in rabbit models. Using the spin-coating technique, Lu et al [ 104 ] designed and fabricated a centrifugally concentric ring-patterned drug-loaded PLGA coating ( Figure 8 ). The concentric ring morphology, drug loading, and release properties were investigated, and the spin-coating parameters were optimized.…”

Section: The Main Types Of Iols Used For Pco Prophylaxismentioning

confidence: 99%

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Zhang

Zhang²,

Chen³

et al. 2022

Pharmaceutics

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Posterior capsular opacification (PCO) is the most common complication resulting from cataract surgery and limits the long-term postoperative visual outcome. Using Nd:YAG laser-assisted posterior capsulotomy for the clinical treatment of symptomatic PCO increases the risks of complications, such as glaucoma, retinal diseases, uveitis, and intraocular lens (IOL) pitting. Therefore, finding how to prevent PCO development is the subject of active investigations. As a replacement organ, the IOL is implanted into the lens capsule after cataract surgery, but it is also associated with the occurrence of PCO. Using IOL as a medium for PCO prophylaxis is a more facile and efficient method that has demonstrated various clinical application prospects. Thus, scientists have conducted a lot of research on new intraocular lens fabrication methods, such as optimizing IOL materials and design, and IOL surface modification (including plasma/ultraviolet/ozone treatment, chemical grafting, drug loading, coating modification, and layer-by-layer self-assembly methods). This paper summarizes the research progress for different types of intraocular lenses prepared by different surface modifications, including anti-biofouling IOLs, enhanced-adhesion IOLs, micro-patterned IOLs, photothermal IOLs, photodynamic IOLs, and drug-loading IOLs. These modified intraocular lenses inhibit PCO development by reducing the residual intraoperative lens epithelial cells or by regulating the cellular behavior of lens epithelial cells. In the future, more works are needed to improve the biosecurity and therapeutic efficacy of these modified IOLs.

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Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification

Cited by 28 publications

References 63 publications

Nanoporous Gold Ring‐Integrated Photothermal Intraocular Lens for Active Prevention of Posterior Capsular Opacification

Nanoporous Gold Ring‐Integrated Photothermal Intraocular Lens for Active Prevention of Posterior Capsular Opacification

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

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