2022
DOI: 10.1128/mbio.00508-22
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Centromere Interactions Promote the Maintenance of the Multipartite Genome in Agrobacterium tumefaciens

Abstract: About 10% of sequenced bacteria have multiple replicons, also known as multipartite genomes. How these multipartite genomes are maintained is still poorly understood.

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Cited by 13 publications
(17 citation statements)
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“…Unlike eukaryotes, bacteria do not have a nucleus, and most of the bacterial genetic material is concentrated in a specific area of the cell, called the nucleoid. To date, spatial genome structure information has been reported for many bacteria, including Caulobacter crescentus ( 13 16 ), Bacillus subtilis ( 17 20 ), Vibrio cholerae ( 21 , 22 ), Mycoplasma pneumoniae ( 23 ), Escherichia coli ( 1 , 24 ), Klebsiella pneumoniae ( 25 ), Rhizobium ( 26 28 ), Acanthamoeba castellanii ( 29 ), Streptomyces ( 30 ), Pseudomonas aeruginosa ( 31 ), and the Oligo-Mouse-Microbiota community ( 32 ).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Unlike eukaryotes, bacteria do not have a nucleus, and most of the bacterial genetic material is concentrated in a specific area of the cell, called the nucleoid. To date, spatial genome structure information has been reported for many bacteria, including Caulobacter crescentus ( 13 16 ), Bacillus subtilis ( 17 20 ), Vibrio cholerae ( 21 , 22 ), Mycoplasma pneumoniae ( 23 ), Escherichia coli ( 1 , 24 ), Klebsiella pneumoniae ( 25 ), Rhizobium ( 26 28 ), Acanthamoeba castellanii ( 29 ), Streptomyces ( 30 ), Pseudomonas aeruginosa ( 31 ), and the Oligo-Mouse-Microbiota community ( 32 ).…”
Section: Introductionmentioning
confidence: 99%
“…How multiple replicons are organized within bacterial cells, how they interact, and whether these interactions help maintain or segregate these multipartite genomes are pending questions. To date, the 3D genomes of a plant symbiont ( Rhizobium ) ( 26 28 ) and a human and aquatic pathogen ( Vibrio ) ( 21 , 22 ) have been reported.…”
Section: Introductionmentioning
confidence: 99%
“…1D ). These interactions are reminiscent of the origin clustering interactions mediated by centromeric proteins in A. tumefaciens , which are critical for the replication and maintenance of the secondary replicons in that bacterium [41, 42]. Notably, the plasmid-chromosome interactions observed here are weaker than those observed in A. tumefaciens , and only 4 out of 18 plasmids showed these specific interactions with the chromosome, thus the biological function of these interactions is unclear (see Discussion).…”
Section: Resultsmentioning
confidence: 77%
“…1D). These interactions are reminiscent of the origin clustering interactions mediated by centromeric proteins in A. tumefaciens, which are critical for the replication and maintenance of the secondary replicons in that bacterium [41,42].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation