2023
DOI: 10.1242/jcs.261150
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Centrosome amplification promotes cell invasion via cell–cell contact disruption and Rap-1 activation

Anu Prakash,
Shishir Paunikar,
Mark Webber
et al.

Abstract: Centrosome amplification (CA) is a prominent feature of human cancers linked to tumourigenesis in vivo. Here, we report mechanistic contributions of CA induction alone to tumour architecture and extracellular matrix (ECM) remodelling. CA induction in non-tumourigenic breast cells MCF10A causes cell migration and invasion, with underlying disruption of epithelial cell-cell junction integrity and dysregulation of expression and subcellular localisation of cell junction proteins. CA also elevates expression of in… Show more

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