CeO2-based peelable gel for neutralization and skin decontamination toward chemical warfare agents

Tailor-Made Synthesis of Cerium Oxide Nanoparticles for Improving the Skin Decontamination of Paraoxon

“…The powder becomes yellow, indicating the production of p -nitrophenol. The same experiment was performed in our research team using a peelable gel incorporating nanoceria . The decontamination system became yellow in the presence of NO in the gel, and PNP was detected as the main degradation product by HPLC after 30 min of contact.…”

“…Considering this crucial aspect, the preference for NO* nanoparticles emerges as a promising choice for decontamination purposes. Research concerning their formulation into easy-to-handle skin decontamination systems should be carefully examined . Besides, we have shown that the CeO 2 NPs powder used in this study should not be able to penetrate human skin under normal conditions.…”

“…The same experiment was performed in our research team using a peelable gel incorporating nanoceria. 23 The decontamination system became yellow in the presence of NO in the gel, and PNP was detected as the main degradation product by HPLC after 30 min of contact. The same mechanism occurs after contact with the skin.…”

“…The efficacy of this peelable gel has been prominently demonstrated, showcasing a remarkable 5-fold reduction in the quantity of POX absorbed into the skin and a substantial 3−4-fold decrease in viable skin in comparison to the nondecontaminated skin. 23 ■ CONCLUSION Skin contamination with toxic agents remains a significant concern, prompting an ongoing search for effective decontamination systems. These systems should not only remove toxic substances from the skin but also degrade them to neutralize their harmful effects.…”

“…3,4,21−23 In vitro experiments, performed using the Franz cell method and skin explants, have also shown that CeO 2 as a powder or suspension is efficient to remove POX from the skin surface and to decrease skin absorption compared to the nondecontaminated control. 3,23 Other studies have focused on the use of ceria for the degradation of various chemicals as VX or Soman. 3,24−26 While the potential of ceria for chemical degradation of toxic substances has been investigated, the impact of nanoparticles' physicochemical properties on degradation remains insufficiently understood.…”