Cephalic phase insulin release in healthy humans after taste stimulation?

Just, Tino; Pau, Hans Wilhelm; Engel, Ulrike; Hummel, Thomas

doi:10.1016/j.appet.2008.04.271

Cited by 111 publications

(91 citation statements)

References 17 publications

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“…A study focusing on aspartame, such as that performed by Just et al (2008) which looked at cephalic insulin response in healthy fasting volunteers after taste stimulation, comparing sucrose, starch and saccharin, warrants further consideration. Studies to answer this question could address appetite in groups with stratified BMIs, those in whom obesity and insulin resistance are co-morbidities, such as impaired glucose tolerance and type 2 diabetes.…”

Section: Resultsmentioning

confidence: 99%

“…In considering the continued increase in the obesity of the population and that more consumers may potentially be turning to calorie free sweeteners and use of calorie free sweeteners, Just et al (2008) looked at cephalic insulin response in healthy fasting volunteers after taste stimulation, comparing sucrose, starch and saccharin and reported that a significant increase of plasma insulin concentration was apparent after stimulation with both sucrose and saccharin. This result suggests that sucrose and saccharin activate a cephalic phase insulin response when applied to the oral cavity only.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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DISCLAIMER The present report is published complying with the transparency principle to which the European Food Safety Authority (EFSA) is subject. The conclusions and recommendations of this report reflect those of the national experts involved in the meetings 2The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EFSA. SUMMARYThe Advisory Forum of EFSA discussed the issue of aspartame in 2007 and at the 24th AF meeting held on 6-7 December 2007 it was agreed that a special meeting would be held on aspartame. This meeting of National Experts was to take place early in 2009 and, as provided in the Terms of Reference endorsed by the Advisory Forum, was to review the information available on aspartame; agree on the completeness of the information ensuring any missing data was added; identify possible data gaps and discrepancies in the available data and where such exist to consider detailed options to address the outstanding issues.An Organising Team, nominated by members of the Advisory Forum, was tasked with preparing for the meetings of National Experts by identifying, collating and reviewing all published papers on aspartame since the review carried out by the Scientific Committee on Food in 2002. In addition the Organising Team also considered available non-peer reviewed information and anecdotal claims by individuals who attributed various symptoms and illnesses directly to aspartame consumption. A meeting was held with interested parties who had submitted information in response to a ‗call for data' published by EFSA in September, 2008.Each of the areas considered, including exposure data, brain function, satiation and appetite, allergenicity and immunotoxicity, metabolic aspects and diabetes, carcinogenicity (including cancer epidemiology) and genotoxicity were considered by the Organising Team and reported on. For each, consistent with the Terms of Reference for the National Expert Meeting, they made preliminary conclusions on whether there were data gaps or discrepancies which required further consideration. This report represents the results of these deliberations.Overall, the Organising Team did not identify any major gaps in information on aspartame and the National Experts agreed with their view. However, several suggestions are made within this report for additional data which would add to the available knowledge on aspartame and its metabolites. To address the communications element of the Terms of Reference a workshop with stakeholders and other interested parties is to be arranged to share and discuss the findings of the work.In conclusion, the National Experts have not identified any new evidence that requires a recommendation to EFSA that the previous Opinions of EFSA and the SCF need to be reconsidered. 3The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EF...

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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“…The pancreas produces large quantities of insulin which it stores in intracellular secretary granules ). Upon stimulation from rising levels of glucose, these granules release their insulin into the mesenteric veins (Juhl et al 2002;Just et al 2008). Insulin secretion is different in healthy and diabetic individuals.…”

Section: Glucose Regulation and Insulin Secretionmentioning

confidence: 99%

Potentials and Limitations of Bile Acids and Probiotics in Diabetes Mellitus

Mikov¹,

Al‐Salami²,

Goločorbin-Kon³

2011

Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments

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“…Em humanos e animais, a gustação de carboidratos pode estimular a secreção de insulina por meio de células beta do pâncreas. (JUST et al, 2008) A insulinogênese pós-estímulo gustativo ocorre antes do aumento plasmático de glicose e apresenta origem cefálica. Os principais elementos reportados como estimulantes dessa fase são carboidratos doces, independentemente de seu valor biológico (JUST et al, 2008).…”

Section: Lactatounclassified

“…Investigações feitas em animais de laboratório sugerem que as vias centrais envolvidas neste reflexo originam-se do diencéfalo (BERTHOUD et al, 1981;JUST et al, 2008).…”

Section: Lactatounclassified

<b>Efeito do enxague oral com carboidrato sobre o desempenho de cavalos da raça Mangalarga Marchador em teste incremental de esforço máximo</b>

Bogossian¹

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Cephalic phase insulin release in healthy humans after taste stimulation?

Cited by 111 publications

References 17 publications

Report of the meeting on Aspartame with National Experts

Report of the meeting on Aspartame with National Experts

Potentials and Limitations of Bile Acids and Probiotics in Diabetes Mellitus

<b>Efeito do enxague oral com carboidrato sobre o desempenho de cavalos da raça Mangalarga Marchador em teste incremental de esforço máximo</b>

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