Cephalopods: The potential for their use in medicine

Беседнова, Н. Н.; Ts, Zaporozhets; Kovalev, N. F.; Макаренкова, И. Д.; Yakovlev, Yu. M.

doi:10.1134/s1063074017020031

Cited by 23 publications

(10 citation statements)

References 34 publications

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“…Penelitian mengenai pencarian dan pengembangan obat-obatan yang berasal dari laut mulai mendapat perhatian dari para peneliti, karena laut sangat kaya bahan bioaktif. Pengembangan senyawa bioaktif alami dari biota laut ini merupakan usaha potensial untuk mendapatkan bahan kimia baru yang berpotensi dalam bidang kesehatan, pertanian dan industri (Besednova et al, 2017).…”

Section: Pendahuluanunclassified

Antibacterial Potential Chloroform Extract of Photobacterium phosphoreum Bacteria Symbiotic in Light Organs of Squid Loligo duvauceli

Putriyani

Pringgenies

Ridlo

2020

J. Molusk. Indones.

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Microorganisms that live in association with marine invertebrates are able to produce a compound similar to those produced by marine invertebrates and are thought to be potential as bioactive materials. Supplement extracts from the Photobacterium phosphoreum bacterial culture have been shown to have antibacterial activity. The purpose of this study was to determine the anti-bacterial activity of the chloroform extract of Photobacterium phosphoreum biomass against pathogenic bacteria Bacillus substilis, Staphylococcus aureus, Salmonella sp. and Escherichia coli. The extraction process was carried out by the liquid-liquid extraction method. Fractionation was performed using Open Column Chromatography (KKT). The antibacterial activity test was conducted by the agar diffusion method according to Kirby-Bauer. The results showed that for the antibacterial activity test of crude extract, the largest inhibition zone diameter occurred in Escherichia coli with a concentration of 50 µg / disk at 24 h incubation, namely (9.80 ± 0.75 mm), while the smallest inhibition zone diameter occurred in Salmonella sp. by giving a concentration of 10 µg / disk at an incubation time of 48 hours, namely (6.03 ± 0.05) mm. Of the 6 fractions resulting from crude extract fractionation, it was known that fraction 5 was the most active fraction and inhibited the growth of the tested bacteria. The largest inhibition zone diameter occurred in Escherichia coli (9.83 ± 0.28) mm, while the smallest inhibition zone diameter occurred in Salmonella sp. (8.63 ± 0.20 mm)

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Section: Pendahuluanunclassified

Antibacterial Potential Chloroform Extract of Photobacterium phosphoreum Bacteria Symbiotic in Light Organs of Squid Loligo duvauceli

Putriyani

Pringgenies

Ridlo

2020

J. Molusk. Indones.

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“…Besides their use as food or food ingredient, evidence of biological activity in cephalopods ink has already been reported mostly for cuttlefish and squid (Nair et al., 2011), finding antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic potential (Besednova, Zaporozhets, Kovalev, Makarenkova, & Yakovlev, 2017). The reported activities offer a protective effect against the development of cancer.…”

Section: Introductionmentioning

confidence: 99%

Octopus vulgaris ink extracts exhibit antioxidant, antimutagenic, cytoprotective, antiproliferative, and proapoptotic effects in selected human cancer cell lines

Hernández-Zazueta

García-Romo

Noguera-Artiaga

et al. 2021

Journal of Food Science

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Cancer is a noncommunicable disease of rising worldwide concern. Marine food products such as Octopus vulgaris ink (OI) could be sources of compounds addressing these concerns. This study aimed to evaluate the antimutagenic, cytoprotective, antiproliferative, proapoptotic, and antioxidant capacity of OI extracts on human cancer cell lines (22Rv1, HeLa, A549). The ARPE‐19 cell line was used as a reference human cell line to evaluate the ink's cytotoxicity. The water extract exhibited the highest antimutagenic and cytoprotective effect, but the dichloromethane extract (DM) showed the lowest half lethal concentration against 22Rv1 cells. Structural elucidation of purified DM fractions (F1, F2, F3) identified an unreported compound, N‐(2‐ozoazepan‐3‐yl)‐pyrrolidine‐2‐carboxamide (OPC). DM‐F2 showed high antiproliferative effect (LC50 = 27.6 µg/mL), reactive species modulation, early‐apoptosis induction (42.9%), and nuclei disruption in 22Rv1 cells. In silico analysis predicted high OPC affinity with Cyclin D1 (−6.70 kcal/mol), suggesting its potential impact on cell cycle arrest. These results highlight the antimutagenic, cytoprotective, and antiproliferative potential health benefits derived from underutilized marine food products such as OI. Further investigations at in vitro or in vivo levels are required to elucidate mechanisms and health benefits from OI. Practical Application O. vulgaris ink is an underutilized marine natural product that could be a source of biological compounds with potential health benefits such as antioxidant activity and cancer prevention.

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“…Squid processing also generates a large amount of byproducts. These represent 35% of the total mass caught and include the head, viscera, skin, and bones [3]. To offset environmental pollution and disposal problems, marine byproducts are used to produce silage, meal, and sauces.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have demonstrated that byproducts from fish, shellfish, and squid processing are suitable for human consumption, animal food, and other applications with high market value [1,2,3]. Indeed, these marine byproducts are a source of interest for their collagen, peptide, polyunsaturated fatty acid, and chitin content.…”

Section: Introductionmentioning

confidence: 99%

Reclamation of Fishery Processing Waste: A Mini-Review

et al. 2019

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Seafood such as fish, shellfish, and squid are a unique source of nutrients. However, many marine processing byproducts, such as viscera, shells, heads, and bones, are discarded, even though they are rich sources of structurally diverse bioactive nitrogenous components. Based on emerging evidence of their potential health benefits, these components show significant promise as functional food ingredients. Fish waste components contain significant levels of high-quality protein, which represents a source for biofunctional peptide mining. The chitin contained in shrimp shells, crab shells, and squid pens may also be of value. The components produced by bioconversion are reported to have antioxidative, antimicrobial, anticancer, antihypertensive, antidiabetic, and anticoagulant activities. This review provides an overview of the extraordinary potential of processing fish and chitin-containing seafood byproducts via chemical procedures, enzymatic and fermentation technologies, and chemical modifications, as well as their applications.

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Cephalopods: The potential for their use in medicine

Cited by 23 publications

References 34 publications

Antibacterial Potential Chloroform Extract of Photobacterium phosphoreum Bacteria Symbiotic in Light Organs of Squid Loligo duvauceli

Antibacterial Potential Chloroform Extract of Photobacterium phosphoreum Bacteria Symbiotic in Light Organs of Squid Loligo duvauceli

Octopus vulgaris ink extracts exhibit antioxidant, antimutagenic, cytoprotective, antiproliferative, and proapoptotic effects in selected human cancer cell lines

Reclamation of Fishery Processing Waste: A Mini-Review

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