Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: materials science approach

Tarasova, N. A.; Галишева, А. О.; Belova, Ksenia; Mushnikova, Anastasia A.; Волокитина, Е. А.

doi:10.15826/chimtech.2022.9.2.09

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Samples of bioceramics La2Zr2O7, La0.9Ca0.1Zr2O6.95 and La0.9Sr0.1Zr2O6.95 were obtained as described earlier [21].…”

Section: Methodsmentioning

confidence: 99%

“…In this research lanthanum zirconate was used, it was chosen was mainly due to the fact that its crystal structure is resistant to various substitutions, including calcium and strontium ions. Earlier basic physical and chemical properties of lanthanum zirconate doped with alkaline earth (Ca, Sr) were studied, the influence of the synthesis method and modification of doping impurities on the target characteristics of materials was determined [21].…”

Section: Introductionmentioning

confidence: 99%

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Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: cytocompatibility in a cell culture model

Ulitko,

Antonets,

Antropova

et al. 2023

Chim.Tech.Acta

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Creation of new ceramic materials for the bone augmentation purposes that combine the absence of cytotoxicity, high strength and osseointegration characteristics is an urgent modern task. In this work, the cytocompatibility of ceramic materials based on lanthanum zirconate (La2Zr2O7) was determined to assess the prospects for their use as implants and components of human joint endoprostheses. The effect of ceramic materials based on undoped and alkali-earth (Ca, Sr) doped La2Zr2O7 on the viability and proliferative activity of human cells was evaluated. The release of elements into the culture medium was also evaluated.

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“…Samples of bioceramics La2Zr2O7, La0.9Ca0.1Zr2O6.95 and La0.9Sr0.1Zr2O6.95 were obtained as described earlier [21].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: cytocompatibility in a cell culture model

Ulitko,

Antonets,

Antropova

et al. 2023

Chim.Tech.Acta

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“…Определение цитосовместимости керамики на основе недопированного и допированного цирконата лантана показало, что при взаимодействии фибробластов человека с исследуемыми керамическими материалами жизнеспособность клеток изменяется в пределах допустимых значений и является достаточной для поддержания их восстановительного потенциала. Вместе с тем необходимы дополнительные исследования для оптимизации интеграции имплантатов из данного материала в костную ткань [78,79].…”

Section: обзор литературыunclassified

Current state and perspectives on the use of zirconium ceramic implants in traumatology and orthopaedics

Volokitina,

Antropova,

Timofeev

et al. 2024

jour

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Background Ceramic materials are currently in wide demand in various fields of medicine. Zirconium ceramics demonstrate exceptional mechanical properties and biocompatibility and do not cause cytotoxic effects or allergic reactions in surrounding tissues.The objective was to present an analysis of current literature data on the use of zirconium ceramics as a bone replacement material in traumatology and orthopaedics.Materials and methods The search for publications was conducted using the databases of Scopus, PubMed and the electronic scientific library eLIBRARY in the Russian and English languages using the keywords: bioceramics, bone, bone defect, zirconate, zirconium ceramics, bone tissue engineering, implant, scaffold, augment, biointegration, bioactivity. Depth of search for scientific papers was from 2000 to 2023.Results and discussion Zirconium dioxide is the main ceramic bioinert material. The study presents the characteristics of ZrO2 as a bone replacement material and its comparison with titanium implants. Data are presented on various strategies for improving zirconium bioceramics: improving the surface of the material by physical and chemical methods, obtaining volumetric porosity, including using additive technologies, creating composite materials, and developing bioactive coatings. New methods of creating zirconium ceramics compatible with living tissues containing bioactive ions that promote both osseointegration and bone tissue regeneration have been actively studied.Conclusions Zirconium dioxide ceramics appear to be a promising alternative to titanium implants in terms of mechanical strength, biological functionality, chemical stability, osseointegration, and antibacterial properties. Future experimental and clinical studies will further improve zirconium ceramics.

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“…To solve these problems, Motameni et al successfully synthesized La 3+ ‐doped DCP (La‐DCP) and 1.5–3.5 wt% graphene oxide (GO)‐doped La DCP bone cement materials. The addition of GO significantly shortened the setting time of La‐DCP and enhanced the mechanical properties and adsorption capacity of bone cement 86 . In addition, La aggregates, such as La2Zr2O7, can be used to fabricate ceramic materials 87 .…”

Section: Tissue Engineering Scaffolds Doped With Metallic Elementsmentioning

confidence: 99%

“…The addition of GO significantly shortened the setting time of La-DCP and enhanced the mechanical properties and adsorption capacity of bone cement. 86 In addition, La aggregates, such as La2Zr2O7, can be used to fabricate ceramic materials. 87 Furthermore, surface chemical modification strategies can yield a TCP-PDLA -5LaB6 scaffold material capable of ablating bone tumors and promoting osteogenesis.…”

Section: Lamentioning

confidence: 99%

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

He,

Li,

et al. 2023

MedComm – Biomaterials and Applications

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The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies.

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Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: materials science approach

Cited by 5 publications

References 23 publications

Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: cytocompatibility in a cell culture model

Ceramic materials based on lanthanum zirconate for the bone augmentation purposes: cytocompatibility in a cell culture model

Current state and perspectives on the use of zirconium ceramic implants in traumatology and orthopaedics

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

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