Ceratonia siliqua L. seed peels: Phytochemical profile, antioxidant activity, and effect on mood disorders

Lakkab, Imane; Hajaji, Hanane El; Lachkar, Nadya; Lefter, Radu; Ciobîcă, Alin; Bali, Brahim El; Lachkar, Mohammed

doi:10.1016/j.jff.2019.01.041

Cited by 30 publications

(34 citation statements)

References 54 publications

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“…The TPC detected in UAE of WG (1.95–2.05 g GAE/100 g raw material or 5.85–6.15 g GAE/100 g extract) was higher than the 16.17 × 10 −6 g GAE/100 g extract found in carob seed peels, extracted with maceration with acetone (Lakkab et al, ).…”

Section: Resultsmentioning

confidence: 92%

Dispersion‐assisted extraction of guarana processing wastes on the obtaining of polyphenols and alkaloids

Santana

Zanini

Macedo

2020

J Food Process Engineering

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This is the first work to evaluate the effects of high shear mixing (HSM) on the recovery of valuable polar compounds from guarana processing wastes (peels and depleted seeds), which results may server to support researches on the valorization of guarana. Under the optimum condition, the HSM was led to extract catechin (11.11–42.93 g/100 g raw material), epicatechin (7.83–24.78 g/100 g raw material) and caffeine (9.99–28.80 g/100 g raw material) from guarana products, which contents were comparable with those obtained with ultrasound assisted extraction and maceration, and significantly higher than those obtained with infusion and decoction. Besides the relatively low reducing sugar content (0.02–0.23 g glucose equivalent/100 g raw material), HSM extracts also presented high antioxidant capacity (25–533 mg ascorbic acid equivalent/g raw material) and phenolic compounds (0.5–45 g catechin equivalent/100 g raw material and 0.1–66.38 g gallic acid equivalent/100 g raw material). The use of pectinase enhanced the HSM to recover target compounds in depleted seeds. Practical applications The use of guarana has emerged as a source of antioxidants, associated to enhancement of cognitive function, to prevent cancer‐related symptoms, and to control the weight. This paper is the first research to use high‐shear mixing (HSM) to maximize the recovery of bioactive compounds from the peels and depleted seeds of guarana, the wastes derived from the Brazilian carbonated beverage industry. The extraction efficiency of HSM for 1 min to recover polyphenols and alkaloids was like those of ultrasound assisted assisted and maceration, performed for 30 min. Our results confirm that HSM is an environmentally friendly, rapid and low‐cost method to extract bioactive compounds from guarana. Our results are expected to support further researches on the use of HSM as an extraction protocol for analysis and to evaluate the multipurpose potential of guarana processing wastes for food and non‐food formulations.

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Section: Resultsmentioning

confidence: 92%

Dispersion‐assisted extraction of guarana processing wastes on the obtaining of polyphenols and alkaloids

Santana

Zanini

Macedo

2020

J Food Process Engineering

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“…In the last years, most of research studies were focused on the discover y of natural compounds with pharmacological properties to exploit them in the prevention and treatment of many serious illnesses. On the other hand, it is known that the disruption of the balance between pro-oxidant and anti-oxidant systems results in oxidative disasters in the respective organisms [1,2].…”

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confidence: 99%

“…ROS induces imbalances in DNA, RNA, proteins, amino acids and unsaturated lipids and, most often, results in the establishment of diseases such as diabetes, cancer, cardiovascular and neurodegenerative diseases [6]. Thus, in order to eliminate ROS [1], various endogenous and exogenous antioxidant systems such as catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) are involved, exogenous intake of antioxidants representing an extra benefit, in the fight against ROS accumulation [7].…”

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confidence: 99%

“…The literature data highlights, on the one hand, the major influence of oxidative stress on mood disorder and / or depression [1,8] and, on the other hand, the role of biological active substances from the various plant products with pharmaco-dynamic action in the prevention and treatment of psychiatric disorders, thus avoiding side effects such as agitation, insomnia, weight gain, restless legs etc., due to allopathic medication administration [9,10].…”

mentioning

confidence: 99%

“…The carob contains a multitude of phytoconstituents such as flavonoids, phenolic compounds, tannins, anthocyanins, alkaloids, glycosides, minerals and proteins [18]. In addition, the literature on the field [1] have shown that the carob extracts have a high antioxidant potency and exert antibacterial, anti-hypercholestrolemic [19], antidiarrheal [20], antifungal, antiinflammator y, antidiabetic, hepatoprotective [21] and antiproliferative effects [22][23][24][25]. Custódio et al 2011 [26] reported the reduction in the viability of different human cell lines by using carob pulp extracts.…”

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confidence: 99%

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Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Hrițcu¹,

Abidar²,

Dumitru³

et al. 2019

Rev. Chim.

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Anxiety and depression are the most common mental disorders that increase morbidity in the world, and recent data (World Health Organization - WHO) show that over 322 million people suffer from depression and anxiety, especially women being more exposed than men. 6-Hydroxydopamine (6-OHDA) is a catecholaminergic neurotoxin which is formed endogenously in patients diagnosed with Parkinson�s disease and has two mechanisms of action. Thus, it easily forms free radicals and is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The treatments administration of 6-OHDA (160 �M) and Ceratonia siliqua L. methanolic extract (0.1 mg/mL, 0.3 mg/mL and 1.0 mg/mL) in Danio rerio specimens affected the acetylcholinesterase activity (AChE) and anxiolytic profile in close correlation with the dose of administered extract, the group with significant differences being the treated one with 6-OHDA alone.

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Protect peanut kernels from Aspergillus spp and their mycotoxins during storage by aqueous extract of carob pulp

El-Desouky

2022

Discov Food

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Recently, the trend of many studies to replace synthetic antifungal commonly used during storage with natural antifungal; Plant extracts has been one of the most promising strategies for this purpose. Therefore, this study aimed to evaluate the aqueous extract of the carob pulp (AECP) at 1.5, 2.5, and 5 mg/ml on the growth of some toxigenic Aspergillus species, and its effectiveness as an anti-mycotoxigenic (aflatoxins (AFs) and ochratoxin A (OTA) during storage red peanut kernels (RPKs) for 90 days. The results indicate that the increased concentration of AECP, the area of inhibition zone increased with all treatments. As well, the strain of Aspergillus ochraceus was more affected by AECP than Aspergillus aflatoxiformans followed by Aspergillus parasiticus which recorded (15.7 ± 0.4 mm), (13.4 ± 0.5 mm), and (11.9 ± 0.4 mm) at 5 mg/ml. Respectively. While, the lowest inhibition was shown with Aspergillus flavus at three concentrations of AECP. The impact of AECP on the accumulation of total AFs and OTA during storage of RPKs infected by A. parasiticus and A. ochraceus, respectively, for 90 days. The results showed that the active compounds in the AECP at 5 mg/ml can protect RPKs for 45 days without detecting any amounts of AFs and OTA. After 90 days, the inhibition percentages for the four types of aflatoxins (AFB1, AFG1, AFB2, AFG2) and OTA compared with positive control samples were 85.1, 76.5, 86.5, 84.2, and 87.5%, respectively. Finally, AFB1 recorded the lowest inhibition percentages of all treatments; on the contrary, it was OTA.

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Ceratonia siliqua L. seed peels: Phytochemical profile, antioxidant activity, and effect on mood disorders

Cited by 30 publications

References 54 publications

Dispersion‐assisted extraction of guarana processing wastes on the obtaining of polyphenols and alkaloids

Dispersion‐assisted extraction of guarana processing wastes on the obtaining of polyphenols and alkaloids

Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Protect peanut kernels from Aspergillus spp and their mycotoxins during storage by aqueous extract of carob pulp

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