Cercariform cells: Another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound‐guided fine‐needle aspirates

Samad, Arbaz; Shah, Akeesha A.; Stelow, Edward B.; Alsharif, Mariam; Cameron, Stuart E. H.; Pambuccian, Stefan E.

doi:10.1002/cncy.21259

Cited by 30 publications

(52 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2 cases cytological smears were available. Both cases showed cytological features of SPN [83]. Some microscopic features of SPN are shown in Figure 1.…”

Section: Microscopic Featuresmentioning

confidence: 84%

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Liszka

Mrowiec²,

Pająk³

et al. 2014

pjp

View full text Add to dashboard Cite

Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.

show abstract

“…In 2 cases cytological smears were available. Both cases showed cytological features of SPN [83]. Some microscopic features of SPN are shown in Figure 1.…”

Section: Microscopic Featuresmentioning

confidence: 84%

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Liszka

Mrowiec²,

Pająk³

et al. 2014

pjp

View full text Add to dashboard Cite

show abstract

“…The present study describes the cytological findings with histologic correlation of two tumors that can appear predominantly in young woman and share some cytologic and histologic similarities such as: papillary pattern, hyaline globules and intercellular basement membrane deposits …”

Section: Discussionmentioning

confidence: 99%

“…Solid pseudopapillary neoplasm of the pancreas (SPNP) is an infrequent tumor reported to account for <3% of all non‐endocrine pancreatic tumors . It frequently appears in young women, and due to its rare aggressive behavior it should be differentiated from other highly metastatic pancreatic neoplasms …”

mentioning

confidence: 99%

Hyaline globules and papillary fragments in cytologic smears from two intra‐abdominal tumors (ovarian and hepatic) in female patients: A diagnostic pitfall with histologic correlation

Machado

López-Soto²,

Pérez-López³

et al. 2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Hyaline globules and papillary fragments in cytologic samples from two intra-abdominal tumors in young females are presented including the cytological features and the correlation with the histopathologic and immunohistochemical findings. In the first case a cytologic study from an ovarian mass showed papillary structures and isolated tumor cells with epithelioid morphology, irregular reniform-like nuclear contour, pale or vacuolated cytoplasm, abundant hyaline globules and occasional glomeruloid structures resembling Schiller-Duval bodies. Yolk sac tumor (YST) was the diagnosis on the histological slides. Tumor cells showed positivity for cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), alpha-fetoprotein (AFP) and Sal-like protein 4 (SALL4). In case number two the cytologic study from a liver metastasis displayed papillary and rosette-like clusters composed of uniform and bland cells showing occasional long cytoplasmic tails, hyaline globules and nuclear grooves. A diagnosis of hepatic metastasis from solid pseudopapillary neoplasm of the pancreas (SPNP) was rendered from the histology. Tumor cells revealed immunoreactivity for cytokeratin (AE1/AE3), Vimentin, Galectin-1 (GAL-1), Neuron specific-enolase, CD10, progesterone and β-catenin (nuclear stain). Regarding differential diagnosis, in the patient with the ovarian mass an ovarian clear cell carcinoma was considered, as well as other germ cell tumors or metastatic carcinoma, while in the patient with a liver metastasis a neuroendocrine carcinoma was taken into account. YST and SPNP share some cytological findings, including hyaline globules, papillary structures, clear cells and intercellular eosinophilic basement membrane deposits. Thus, a detailed study and careful interpretation of the cytological, histological and immunohistochemical findings may be worthwhile to avoid a potential misdiagnosis, particularly in the cytologic specimens of the ovarian and/or intra-abdominal mass, when involving young females. Diagn. Cytopathol. 2016;44:935-943. © 2016 Wiley Periodicals, Inc.

show abstract

“…Another modern procedure used in preoperative evaluation is endoscopic ultrasound (EUS) with fine needle aspiration biopsy (FNA) [11]. In differential diagnosis acinar cell carcinoma, pancreatoblastoma, neuroendocrine neoplasms, metastatic adenocarcinomas as well as non-neoplastic lesions such as post-inflammatory pseudocyst, parasitic cyst or ectopic spleen also have to be included [4].…”

mentioning

confidence: 99%

“…Nuclear staining with β-catenin is regarded as a specific and sensitive marker of solid pseudopapillary tumor. In the available literature expression of a variety of antigens, e.g., vimentin, CD10 and neuroendocrine markers such as synaptophysin and CD56, was also observed [11,12]. It should be noted that progesterone receptor expressed by the tumor may be responsible for its rapid growth during pregnancy and puerperium [8].…”

mentioning

confidence: 99%

Solid-pseudopapillary neoplasm of the pancreas – comparisons between magnetic resonance and histological findings

Burdan¹,

Mocarska²,

Guz³

et al. 2013

pjp

View full text Add to dashboard Cite

Solid-pseudopapillary neoplasm is a rare pancreatic tumor typically observed in young adults. A new case of the tumor was diagnosed in a 22-year-old woman. An abnormal mass connected with the pancreatic body was found on ultrasound and computed tomography. Magnetic resonance revealed weak homogeneous contrast enhancement and a low ADC value (0.824 mm/s 2 ; b1000). Primary radiological diagnosis suggested a solid pancreatic neoplasm, which was confirmed during histopathological assessment after resection of the pancreatic body with preservation of the spleen and normal drainage through the main pancreatic duct. Histological appearance of the solid-pseudopapillary neoplasm corresponded with its radiological morphology.

show abstract

Cercariform cells: Another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound‐guided fine‐needle aspirates

Cited by 30 publications

References 65 publications

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Hyaline globules and papillary fragments in cytologic smears from two intra‐abdominal tumors (ovarian and hepatic) in female patients: A diagnostic pitfall with histologic correlation

Solid-pseudopapillary neoplasm of the pancreas – comparisons between magnetic resonance and histological findings

Contact Info

Product

Resources

About