Cerebellar involvement in verb generation: An fMRI study

Frings, Markus; Dimitrova, Albena; Schorn, Christoph F.; Elles, Hans-Gerd; Hein-Kropp, Christoph; Gizewski, Elke R.; Diener, Hans Christoph; Timmann, Dagmar

doi:10.1016/j.neulet.2006.08.058

Cited by 130 publications

(103 citation statements)

References 17 publications

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“…The localization of speech function in the rostral cerebellum has been reported in fMRI studies [12,13]. These fMRI studies showed that speech production relied on the paravermal lobulus simplex in the rostral cerebellum [12,13]. Previously, we reported a patient with isolated dysarthria caused by cerebellar infarction.…”

Section: Introductionmentioning

confidence: 79%

“…Localization of speech function in the upper cerebellum has been studied in previous reports [12,13]. Frings M et al reported that speech production relied on the paravermal zone of the bilateral lobulus simplex, whereas verb generation was associated with the lateral hemispheral part of the lobulus simplex, based on their fMRI study [13]. Dresel C et al reported a fMRI study of whistling [12].…”

Section: Discussionmentioning

confidence: 99%

“…The infarcts in the other 3 patients [2,[14][15][16] were anatomically localized in the lobulus quadrangularis and lobulus simplex. Localization of speech function in the upper cerebellum has been studied in previous reports [12,13]. Frings M et al reported that speech production relied on the paravermal zone of the bilateral lobulus simplex, whereas verb generation was associated with the lateral hemispheral part of the lobulus simplex, based on their fMRI study [13].…”

Section: Discussionmentioning

confidence: 99%

“…Recent functional MRI (fMRI) data emphasized the right cerebellar hemisphere as well as the dorsolateral and medial areas of the left (language-dominant) frontal lobe for speech function [11]. The localization of speech function in the rostral cerebellum has been reported in fMRI studies [12,13]. These fMRI studies showed that speech production relied on the paravermal lobulus simplex in the rostral cerebellum [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…In this report, we have included an additional patient who showed isolated dysarthira caused by cerebellar infarction. We studied the responsible lesion for dysarthria in the cerebellum, based on the localization of the lesions in patients with isolated dysarthria caused by cerebellar infarction [2,[14][15][16][17], and the recently reported fMRI data on speech function in the cerebellum [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Two patients with isolated dysarthria caused by cerebellar infarction

et al. 2013

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Two patients with isolated dysarthria caused by cerebellar infarction

et al. 2013

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Cerebellar morphology in Tourette syndrome and obsessive‐compulsive disorder

Tobe

Bansal

et al. 2010

Annals of Neurology

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Objective Neuroanatomical and functional imaging studies have identified the cerebellum as an integral component of motor and language control. Few studies, however, have investigated the role of the cerebellum in Tourette syndrome (TS), a condition defined by the presence of semi-involuntary movements and sounds. Methods Magnetic resonance imaging was conducted in 163 persons with TS and 147 control participants. Multivariate linear regression models were used to explore effects on cerebellar surface morphology and underlying volumes for the main diagnosis effects of TS as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder. Additionally, the correlations of symptom severity with cerebellar morphology were also assessed. Results The TS group demonstrated reduced volumes of the cerebellar hemispheres bilaterally that derived primarily from reduced gray matter in crus I and lobules VI, VIIB, and VIIIA. These decreased regional volumes accompanied increasing tic symptom severity and motoric disinhibition as demonstrated by a finger tapping test. Males had reduced volumes of these same regions compared with females, irrespective of diagnosis. Comorbid OCD was associated with relative enlargement of these regions in proportion to the increasing severity of OCD symptoms. Interpretation The cerebellum is involved in the pathogenesis of TS and tic-related OCD. Baseline gender differences in cerebellar morphology may in part account for the more prevalent expression of TS in males.

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Cerebellar gray matter differentiates children with early language delay in autism

et al. 2016

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Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8-13 year old children with autism (n = 13 ELD; n = 22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. Autism Res 2016, 9: 1191-1204. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Cerebellar involvement in verb generation: An fMRI study

Cited by 130 publications

References 17 publications

Two patients with isolated dysarthria caused by cerebellar infarction

Two patients with isolated dysarthria caused by cerebellar infarction

Cerebellar morphology in Tourette syndrome and obsessive‐compulsive disorder

Cerebellar gray matter differentiates children with early language delay in autism

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