Cerebellar liponeurocytoma

Abstract

A case of cerebellar liponeurocytoma in a 34-year-old man is reported. There are only 19 other cases reporting this entity in the medical literature. The diagnostic, radiological and clinical features associated with this tumour are reviewed and discussed in relation to our case. The differences in behaviour and prognosis between medulloblastoma and cerebellar liponeurocytoma are presented with the corresponding implications for management.

Cerebellar liponeurocytoma with extracranial extension: Case report

“…Symptomatic period prior to presentation is often long [2]. Patients usually present between the ages of 58 and 60 years [11] with no sex predilection.…”

“…Obstructive hydrocephalus is common and may be the reason for presentation [10]. Clinically, headache and other signs of raised increased intracranial pressure are the most common presenting symptoms [2]. Other manifestations include dizziness, unsteadiness, gait disturbance, frequent falls, visual symptoms, and signs of cerebellar or brainstem dysfunction depending on the tumor location [12].…”

“…Cerebellar liponeurocytoma is a rare neoplasm with distinctive morphologic features, involving typically the cerebellar hemispheres of middle-aged to older adults and composed of densely packed neuronal cells mixed to foci of well-differentiated adipocyte-like cells, amazingly resembling to mature adipose tissue [1,2].…”

Neuronal and Mixed Neuronal-Glial Tumors of the Central Nervous System

“…In the 29 patients with cerebellar liponeurocytoma reported ( 182,185,186,187,188,189), the mean age was around 50 years (range, 24-77 years), with a peak in the third to sixth decade of life. This is in contrast with the age distribution of cerebellar medulloblastomas, more than 70% of which occur in children (178).…”

“…Most importantly, the growth fraction is in the range of 15-40%, which is incompatible with a diagnosis of liponeurocytoma. Cerebellar liponeurocytoma is a neoplasm of adults, while lipidized medulloblastomas also occur in children (186,188,197,198,199). The liponeurocytomas may also mimic neoplastic oligodendrocytes and clear cell ependymoma (199).…”