Cerebral Blood Flow and Metabolism in Psychoses of Senility

Freyhan, Fritz A.; Woodford, Rachel B.; Kety, Seymour S.

doi:10.1097/00005053-195101000-00045

Cited by 40 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These higher rates produce a larger "substrate" for homeostatic reversal, resulting in higher delta levels. At the time the 1974 model was proposed, crosssectional studies had shown that waking whole brain metabolic rate declines over adolescence by 20 -30% (23), an amount equal to the average difference between Alzheimer disease and normal elderly (16). Later cross-sectional measurements of "cortical" metabolic rate with PET demonstrated a 50% decline across adolescence (6).…”

Section: Discussionmentioning

confidence: 99%

The adolescent decline of NREM delta, an indicator of brain maturation, is linked to age and sex but not to pubertal stage

Feinberg¹,

Higgins²,

Khaw³

2006

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Two dramatic phenomena of human adolescence are sexual maturation and a steep decline in the delta EEG of non-rapid eye movement (NREM) sleep. It has long been speculated that these developmental changes are causally related. Here, we present the first longitudinal data on this issue. Cohorts of 9- and 12-year-old children (n = 31, 38) were studied with in-home sleep EEG recordings at 6-mo intervals over 2 years. Pubertal (Tanner) stage, height, and weight were obtained at each time point. NREM delta power density (DPD) did not change significantly over ages 9-11 years, and its level did not differ in boys and girls. DPD declined by 25% between ages 12 and 14 years. This decline was parallel in the two sexes, but levels were lower in girls, suggesting that their DPD decline began earlier. Mixed effect analyses demonstrated that DPD was strongly related to age with Tanner stage, height, weight and body mass index controlled but that none of these measures of physical and sexual development was related to DPD with age controlled. NREM delta is the sleep EEG component homeostatically related to prior waking duration and the intensity of waking brain activity. We hypothesize that the DPD decline is caused by age-programmed synaptic pruning that decreases waking brain metabolic rate. This reduced rate would decrease the "substrate" for delta homeostasis. Whether or not this interpretation proves correct, these longitudinal data demonstrate that the delta decline in adolescence reflects brain processes that are not predicted by physical growth or sexual maturation.

show abstract

Section: Discussionmentioning

confidence: 99%

The adolescent decline of NREM delta, an indicator of brain maturation, is linked to age and sex but not to pubertal stage

Feinberg¹,

Higgins²,

Khaw³

2006

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…For instance, over 60 years ago, cerebral blood flow in humans was assessed by having research participants inhale nitrous oxide and measuring the difference in nitrous oxide concentration in blood samples simultaneously collected with needles inserted in the femoral artery and in the jugular vein (Kety & Schmidt, 1945, 1948. The application of this technique to address age-related issues followed shortly thereafter (Freyhan, Woodford, & Kety, 1951;Kety, 1956), with authors suggesting that observed reductions in cerebral blood flow in older adults reflected neuronal loss. Despite these early attempts to link cerebral changes to aging, neuroimaging of aging studies have only recently proliferated, with the development of less invasive imaging techniques, leading to significant advances in cognitive aging research.…”

Section: Imaging Agingmentioning

confidence: 99%

Present and Future

2019

A Fossil History of Southern African Land Mammals

View full text Add to dashboard Cite

“…Concurrently, pathologic defenses become grotesquely elaborated into delusional transformations in efforts toward restitution. Finally, superimposed on this entire endopsychic process and pervading it, is the probable physiologic factor of cerebral ischemia (3,4). HYPOTHESIS Levy's recent excellent summary (5) of the literature and research concerning the medical management of the aged outlines thoroughly the rationale lying at the basis of the use of an analeptic drug.…”

Section: Introductionmentioning

confidence: 99%