Cerebral blood flow in the subgenual anterior cingulate cortex and modulation of the mood-regulatory networks in a successful rTMS treatment for major depressive disorder

Abstract

The subgenual anterior cingulate cortex (Cg25) has been reported to be a node of mood-regulatory networks. Using a responder and a non-responder of repetitive transcranial magnetic stimulation (rTMS) for depression, we examined pre/post-treatment cerebral blood flow (CBF) in the Cg25 and treatment-related CBF changes in cortical/subcortical regions. In the responder, pre-treatment Cg25 perfusion was higher and was decreased after treatment, in addition, CBF was increased in the frontal and parietal regions and decreased in the hippocampus and basal ganglia. Our results suggest that rTMS treatment response may be related to pre-treatment Cg25 activity and modulation of the Cg25 and mood-regulatory networks.

Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry

“…It is also important to examine the phenotypes at various levels, including at the level of the brain neural circuits, brain function, brain structure, cell function, and molecular and gene expressions and to further classify MDD and BD with various coexisting pathological conditions from the viewpoint of volume reduction in the sgACC and SCA for investigating disease pathogenesis …”

“…B, the z score threshold in the SCA was determined to be 0.810, with an AUC of 0.751 further classify MDD and BD with various coexisting pathological conditions from the viewpoint of volume reduction in the sgACC and SCA for investigating disease pathogenesis. [39][40][41][42]…”

Neurobiological Predictors of Response to Dorsolateral Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation in Depression: A Systematic Review

“…With respect to limbic cortex, a positive correlation was observed be-tween baseline rCBF/activity and symptom improvement post HFL-rTMS in the ACC [33] and pregenual cingulate cortex. [50] In the insula, treatment response to HFL-rTMS presented as a negative correlation to baseline rCBF/activity, [49] whereas treatment response to LFR-rTMS was found to show a positive correlation with baseline rCBF/activity. [50] In the insula, treatment response to HFL-rTMS presented as a negative correlation to baseline rCBF/activity, [49] whereas treatment response to LFR-rTMS was found to show a positive correlation with baseline rCBF/activity.…”

“…[14] Likewise, a positive correlation was seen between baseline rCBF/activity in the subgenual cingulate cortex and symptom improvement post LFR-rTMS [27,48] , as well as post bilateral-rTMS. [50] In the insula, treatment response to HFL-rTMS presented as a negative correlation to baseline rCBF/activity, [49] whereas treatment response to LFR-rTMS was found to show a positive correlation with baseline rCBF/activity. [48] Amygdala.…”

“…Takahashi et al [50] TRD 50% reduction in baseline HAM-D 1-sertraline, 1-paroxetine 2 L DLPFC, 110% motor threshold, 10 Hz, 30 5-s trains, 55-s intertrain interval, 1,500 stimuli/session, 20 sessions…”