Cerebral Evoked Potentials in Patients at an Early Stage of Schizophrenia

Osokina, O.I.; Ivnyev, B. B.

doi:10.1007/s11062-018-9751-1

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…There is strong evidence associating hyporeactivity with SSD and disease progression (Javitt et al, 2018; Koshiyama et al, 2020). Hyporeactive neural responses in SSD are cataloged across a variety of measures, including preconscious deviance detection (mismatch negativity: MMN) in visual (Farkas et al, 2015; Urban et al, 2008) and auditory domains (Erickson et al, 2016; Haigh, Coffman, et al, 2016; Joshi et al, 2018; Koshiyama et al, 2020; Umbricht & Krljes, 2005), and reduced N1 responses to visual (Antonova et al, 2021; Hoptman et al, 2018; Neuhaus et al, 2011) and auditory stimuli (Force et al, 2008; Mathalon et al, 2019; Osokina & Ivnyev, 2018; Perez et al, 2012). Hyporeactive BOLD responses in fMRI designs are observed in early visual, auditory, and somatosensory cortices (Gaebler et al, 2015; Haenschel et al, 2007; Haigh, Gupta, et al, 2016; Hoptman et al, 2010; Martínez et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

People with high schizotypy experience more illusions in the Pattern Glare Test: Consistent with the hyperexcitability hypothesis

Torrens

Pablo

Shires

et al. 2022

Eur J of Neuroscience

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Individuals diagnosed with schizophrenia spectrum disorders (SSD) exhibit a constellation of sensory and perceptual impairments, including hyporeactivity to external input. However, individuals with SSD also report subjective experiences of sensory flooding, suggesting sensory hyperexcitability. To identify the extent to which behavioural indices of hyperexcitability are related to nonpsychotic symptoms of schizophrenia, we tested a non-clinical population measured for schizophrenia-like traits (schizotypy), and a behavioural measure of sensory hyperexcitability, specifically the number of illusions seen in the Pattern Glare Test. Two samples totaling 913 individuals completed an online version of the Schizotypal Personality Questionnaire -Brief Revised (SPQ-BR) and the Pattern Glare Test. Individuals with higher schizotypy traits reported more illusions in the Pattern Glare Test. Additionally, one of the three SPQ-BR factors, the disorganized factor, significantly predicted the number of illusions reported. These data illustrate the potential for research in non-clinical samples to inform clinically relevant research.

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Section: Discussionmentioning

confidence: 99%

People with high schizotypy experience more illusions in the Pattern Glare Test: Consistent with the hyperexcitability hypothesis

Torrens

Pablo

Shires

et al. 2022

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…There is strong evidence associating hyporeactivity with SSD and disease progression (Javitt et al, 2018;Koshiyama et al, 2020). Hyporeactive neural responses in SSD are cataloged across a variety of measures, including preconscious deviance detection (mismatch negativity: MMN) in visual (Farkas et al, 2015;Urban et al, 2008) and auditory domains (Erickson et al, 2016;Haigh et al, 2016a;Joshi et al, 2018;Koshiyama et al, 2020;Umbricht & Krljes, 2005), and reduced N1 responses to visual (Antonova et al, 2021;Hoptman et al, 2018;Neuhaus et al, 2011) and auditory stimuli (Force et al, 2008;Mathalon et al, 2019;Osokina & Ivnyev, 2018;Perez et al, 2012). Hyporeactive BOLD responses in fMRI designs are observed in early visual, auditory, and somatosensory cortices (Gaebler et al, 2015;Haenschel et al, 2007;Haigh et al, 2016b;Hoptman et al, 2010;Martínez et al, 2018).…”

Section: Implications: Neural Mechanisms Of Hyporeactivity Versus Hyp...mentioning

confidence: 99%

People with High Schizotypy Experience More Illusions in the Pattern Glare Test: Consistent with the Hyperexcitability Hypothesis

Torrens

Pablo

Shires

et al. 2022

Preprint

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Individuals diagnosed with schizophrenia spectrum disorders (SSD) exhibit a constellation of sensory and perceptual impairments, including hyporeactivity to external input. However, individuals with SSD also report subjective experiences of sensory flooding, suggesting sensory hyperexcitability. To identify the extent to which behavioral indices of hyperexcitability are related to non-psychotic symptoms of schizophrenia, we tested a non-clinical population measured for schizophrenia-like traits (schizotypy), and a behavioral measure of sensory hyperexcitability, specifically the number of illusions seen in the Pattern Glare Test. Two samples totaling 913 individuals completed an online version of the Schizotypal Personality Questionnaire – Brief Revised (SPQ-BR) and the Pattern Glare Test. Individuals with higher schizotypy traits reported more illusions in the Pattern Glare Test. Additionally, one of the three SPQ-BR factors, the disorganized factor, significantly predicted the number of illusions reported. These data illustrate the potential for research in non-clinical samples to inform clinically relevant research.

show abstract

Cerebral Evoked Potentials in Patients at an Early Stage of Schizophrenia

Cited by 2 publications

References 11 publications

People with high schizotypy experience more illusions in the Pattern Glare Test: Consistent with the hyperexcitability hypothesis

People with high schizotypy experience more illusions in the Pattern Glare Test: Consistent with the hyperexcitability hypothesis

People with High Schizotypy Experience More Illusions in the Pattern Glare Test: Consistent with the Hyperexcitability Hypothesis

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